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Cefadroxil chewable tablets and preparation method thereof

A technology of cefadroxil chewable tablets and cefadroxil, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of lack of access to excipients and their dosage, Discomfort, not given, etc.

Active Publication Date: 2012-09-26
金鸿药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although the above-mentioned literature mentions a kind of cefadroxil chewable tablet, because cefadroxil tablet has a specific smell, it makes people feel uncomfortable, how to effectively cover the smell to ensure the patient's medication compliance, and at the same time To ensure that the drug effect is equal to or better than the existing preparations, the above-mentioned documents do not give more teachings or inspirations, and there is no technical inspiration about the suitable excipients and dosage of cefadroxil chewable tablets from the above-mentioned documents

Method used

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  • Cefadroxil chewable tablets and preparation method thereof
  • Cefadroxil chewable tablets and preparation method thereof
  • Cefadroxil chewable tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] (1) Prescription

[0093] Ingredients 1000 pieces (g)

[0094] Cefadroxil 132g (equivalent to cefadroxil anhydrous 125g)

[0095] Mannitol 250g

[0096] Sucrose 123g

[0097] Maltodextrin 22g

[0098] Aspartame 1g

[0099] Sweet Orange Powder Flavor 15g

[0100] Menthol 1g

[0101] Appropriate amount of water

[0102] Magnesium Stearate 5.5g

[0103] (2) Preparation process

[0104] Weigh cefadroxil passing through a 100-mesh sieve and mannitol, maltodextrin, sucrose, aspartame, menthol and sweet orange powder essence passing through a 80-mesh sieve, mix them evenly in a one-step granulator, and spray an appropriate amount of Granulate with water, weigh after drying, take 1% magnesium stearate, add it into a dry blender and mix with the dry granules evenly, compress the semi-finished product after the content is qualified, and the theoretical tablet weight is 550mg.

Embodiment 2

[0106] (1) Prescription

[0107] Ingredients 1000 pieces (g)

[0108] Cefadroxil 264g (equivalent to 250g cefadroxil anhydrous)

[0109]Mannitol 500g

[0110] Sucrose 246g

[0111] Maltodextrin 44g

[0112] Aspartame 2g

[0113] Sweet Orange Powder Flavor 30g

[0114] Menthol 2g

[0115] Appropriate amount of water

[0116] Magnesium Stearate 11g

[0117] (2) Preparation process

[0118] 1) Cefadroxil, mannitol, maltodextrin, sucrose, aspartame and menthol are pulverized and sieved respectively;

[0119] 2) Mix the cefadroxil, mannitol, maltodextrin, sucrose, aspartame, menthol and sweet orange powder flavor that have been crushed and sieved in the previous step, and then spray an appropriate amount of water to granulate and dry to obtain dry granules ;

[0120] 3) Add magnesium stearate to the dry granules obtained in the upward step, mix evenly, and compress the semi-finished product to obtain final product.

Embodiment 3

[0122] (1) Prescription

[0123] Ingredients 1000 pieces (g)

[0124] Cefadroxil 528 parts by weight

[0125] Mannitol 240 parts by weight

[0126] 130 parts by weight of sucrose

[0127] Maltodextrin 88 parts by weight

[0128] Aspartame 4 parts by weight

[0129] 60 parts by weight of sweet orange powder essence

[0130] Menthol 4 parts by weight

[0131] Appropriate amount of water

[0132] 11 parts by weight of magnesium stearate.

[0133] (2) Preparation process

[0134] 1) Cefadroxil is crushed through a 100-mesh sieve, and mannitol, maltodextrin, sucrose, aspartame, and menthol are respectively crushed through a 80-mesh sieve;

[0135] 2) Weigh the cefadroxil, mannitol, maltodextrin, sucrose, aspartame, menthol and sweet orange powder essence that have been pulverized and sieved in the previous step according to the above dosage, and put them in a one-step granulator at a speed of 30r / min After mixing for 20 minutes under certain conditions, mix evenly, then s...

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Abstract

The invention relates to cefadroxil chewable tablets and a preparation method thereof. The cefadroxil chewable tablets provided by the invention comprise the following raw material components in parts by weight: 110-550 parts of cefadroxil, 240-1,050 parts of mannitol, 110-500 parts of sucrose, 15-90 parts of maltodextrin, 0.5-5 parts of aspartame, 10-70 parts of sweet orange powder essence, 0.5-5 parts of menthol, a proper amount of water and 3-25 parts of magnesium stearate. The cefadroxil chewable tablets provided by the invention have high absorption speed, no lingering bitterness and excellent mouthfeel.

Description

technical field [0001] The invention relates to a cefadroxil chewable tablet and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Cefadroxil is a semi-synthetic oral effective broad-spectrum cephalosporin antibacterial drug, which belongs to the first generation of cephalosporins and is clinically used to treat bacterial infections. It has bactericidal effect on Gram-positive and negative bacteria, and its bactericidal effect in vitro is more significant than other oral cephalosporins. Although the second, third, and fourth-generation cephalosporins have appeared, they are still widely used clinically because of their good oral absorption, multiple dosage forms, long-lasting effects, and good curative effects. [0003] The slower rate of absorption and urinary excretion of cefadroxil distinguishes it pharmacokinetically from other oral cephalosporins currently available. Therefore, it can maintain an effective bacte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/545A61K47/36A61P31/04
Inventor 上官清
Owner 金鸿药业股份有限公司
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