Cefadroxil chewable tablets and preparation method thereof

A cefadroxil chewable tablet, cefadroxil technology, applied in the direction of medical formula, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve the problem of not giving, discomfort, lack of excipients and Issues such as the technical inspiration of its dosage

Active Publication Date: 2011-11-23
金鸿药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although the above-mentioned literature mentions a kind of cefadroxil chewable tablet, because cefadroxil tablet has a specific smell, it makes people feel uncomfortable, how to effectively cover the smell to ensure the patient's medication compliance, and at the same time To ensure

Method used

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  • Cefadroxil chewable tablets and preparation method thereof
  • Cefadroxil chewable tablets and preparation method thereof
  • Cefadroxil chewable tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0091] Example 1

[0092] (1) Prescription

[0093] Ingredients 1000 pieces (g)

[0094] Cefadroxil 132g (equivalent to 125g of cefadroxil anhydrous)

[0095] Mannitol 250g

[0096] Sucrose 123g

[0097] Maltodextrin 22g

[0098] Aspartame 1g

[0099] Sweet orange powder flavor 15g

[0100] Menthol 1g

[0101] Water

[0102] Magnesium stearate 5.5g

[0103] (2) Preparation process

[0104] Weigh the cefadroxil that has passed through a 100-mesh sieve and mannitol, maltodextrin, sucrose, aspartame, menthol and orange powder that have passed through an 80-mesh sieve, and mix them in a one-step granulator, and spray an appropriate amount Granulate with water and weigh after drying. Weigh 1% magnesium stearate, add it to a dry blender and mix with the dried granules evenly. After the content of the semi-finished product is qualified, press the tablet. The theoretical tablet weight is 550 mg.

Example Embodiment

[0105] Example 2

[0106] (1) Prescription

[0107] Ingredients 1000 pieces (g)

[0108] Cefadroxil 264g (equivalent to 250g of cefadroxil anhydrous)

[0109] Mannitol 500g

[0110] Sucrose 246g

[0111] Maltodextrin 44g

[0112] Aspartame 2g

[0113] Sweet orange powder flavor 30g

[0114] Menthol 2g

[0115] Water

[0116] Magnesium stearate 11g

[0117] (2) Preparation process

[0118] 1) Cefadroxil, mannitol, maltodextrin, sucrose, aspartame and menthol were crushed and sieved;

[0119] 2) Mix the powdered essences of cefadroxil, mannitol, maltodextrin, sucrose, aspartame, menthol and sweet orange that have been crushed and sieved in the previous step, and then sprayed into appropriate amount of water to granulate and dry to obtain dry granules ;

[0120] 3) Magnesium stearate is added to the dry granules obtained in the upper step, mixed uniformly, and the content of the semi-finished product is qualified, and then compressed into tablets.

Example Embodiment

[0121] Example 3

[0122] (1) Prescription

[0123] Ingredients 1000 pieces (g)

[0124] Cefadroxil 528 parts by weight

[0125] Mannitol 240 parts by weight

[0126] 130 parts by weight of sucrose

[0127] 88 parts by weight of maltodextrin

[0128] Aspartame 4 parts by weight

[0129] Orange powder flavor 60 parts by weight

[0130] 4 parts by weight of menthol

[0131] Water

[0132] 11 parts by weight of magnesium stearate.

[0133] (2) Preparation process

[0134] 1) Cefadroxil is crushed through a 100 mesh sieve, mannitol, maltodextrin, sucrose, aspartame, and menthol are crushed through an 80 mesh sieve;

[0135] 2) Weigh the cefadroxil, mannitol, maltodextrin, sucrose, aspartame, menthol and sweet orange powder flavors that have been crushed and sieved in the previous step according to the above-mentioned amount in a one-step granulator at a speed of 30r / min After mixing for 20 minutes under the conditions of, the mixture is evenly mixed, and then an appropriate amount of water is spray...

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Abstract

The invention relates to cefadroxil chewable tablets and a preparation method thereof. The cefadroxil chewable tablets provided by the invention comprise the following raw material components in parts by weight: 110-550 parts of cefadroxil, 240-1,050 parts of mannitol, 110-500 parts of sucrose, 15-90 parts of maltodextrin, 0.5-5 parts of aspartame, 10-70 parts of sweet orange powder essence, 0.5-5 parts of menthol, a proper amount of water and 3-25 parts of magnesium stearate. The cefadroxil chewable tablets provided by the invention have high absorption speed, no lingering bitterness and excellent mouthfeel.

Description

technical field [0001] The invention relates to a cefadroxil chewable tablet and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Cefadroxil is a semi-synthetic oral effective broad-spectrum cephalosporin antibacterial drug, which belongs to the first generation of cephalosporins and is clinically used to treat bacterial infections. It has bactericidal effect on Gram-positive and negative bacteria, and its bactericidal effect in vitro is more significant than other oral cephalosporins. Although the second, third, and fourth-generation cephalosporins have appeared, they are still widely used clinically because of their good oral absorption, multiple dosage forms, long-lasting effects, and good curative effects. [0003] The slower rate of absorption and urinary excretion of cefadroxil distinguishes it pharmacokinetically from other oral cephalosporins currently available. Therefore, it can maintain an effective bacte...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/545A61K47/36A61P31/04
Inventor 上官清
Owner 金鸿药业股份有限公司
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