Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of polydatin in the preparation of sunscreen cosmetics

A technology of cosmetics, polydatin, applied in the field of natural plant extract polydatin

Inactive Publication Date: 2011-11-30
EAST CHINA NORMAL UNIV
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no relevant literature reports on the role of polydatin in photodamage protection at home and abroad so far.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of polydatin in the preparation of sunscreen cosmetics
  • Application of polydatin in the preparation of sunscreen cosmetics
  • Application of polydatin in the preparation of sunscreen cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, Ultraviolet (UVB) irradiation dose determination of HaCaT cells

[0039] HaCaT cells in 96-well plates, using 30mJ / cm 2 、60mJ / cm 2 、90mJ / cm 2 and 120mJ / cm 2 The UVB dose was irradiated, and a blank group that did not receive irradiation was set up. The cell viability of each group was measured by MTS method as follows: figure 1 . figure 1 It shows that the semi-lethal dose of UVB irradiated HaCaT cells is 90mJ / cm 2 , so all future experiments use 90mJ / cm 2 As the damaging dose of UVB irradiated cells.

Embodiment 2

[0040] Embodiment 2, the protective effect of polydatin on HaCaT cells irradiated by UVB

[0041] UVB irradiation made the lethality of HaCaT cells in the control group less than half lethal, and greatly reduced the proliferation activity of HaCaT cells. When the concentration of polydatin is 10 μg / ml, it can significantly protect HaCaT cells from UVB damage, such as figure 2 Shown, and this protective effect is dose-dependent in the concentration of polydatin in the range of 10-200 μg / ml. figure 2 Compared with the UV control group, *P<0.05, **P<0.01, ***P<0.001.

Embodiment 3

[0042] Embodiment 3, the effect of polydatin on the activity of HaCaT cells

[0043] After HaCaT cells were treated with different concentrations of polydatin (20 μg / ml, 40 μg / ml, 80 μg / ml, 100 μg / ml, 150 μg / ml, 200 μg / ml) for 24 hours, the cell proliferation activity was detected by MTS method, and the results were as follows: image 3 shown. image 3 Among them, compared with the UV control group, *P<0.05, **P<0.01, ***P<0.001. When the concentration of polydatin is below 80 μg / ml, it has almost no effect on the proliferation activity of HaCaT cells; while when the concentration of polydatin reaches 100 μg / ml and above, it can significantly inhibit the proliferation activity of HaCaT cells. Therefore, polydatin concentrations of 20 μg / ml, 40 μg / ml and 80 μg / ml were selected as drug concentrations for cell and molecular mechanism research in the present invention.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the application of polydatin in the preparation of sunscreen cosmetics. Polydatin can obviously resist the damage of ultraviolet rays to human epidermal cells at the cellular level, and can obviously protect the skin of mice due to ultraviolet rays at the animal level, and the anti-ultraviolet effect is remarkable. Polydatin of the present invention is used in sunscreen cosmetics, and can be used in the form of cosmetic additives, or made into sunscreen creams, emulsions, facial masks, toners, skin care water, ointments, oils, gels, aerosols, solutions, Or coating agent and other various dosage forms.

Description

technical field [0001] The invention relates to a new application of polydatin, a natural plant extract, in particular to the application of polydatin in the preparation of sunscreen cosmetics. Background technique [0002] As an effective barrier against environmental and exogenous harmful substances, the skin protects various organs in the human body. Excessive or long-term exposure of the skin to the sun's ultraviolet rays can cause many skin diseases, and is an important factor in dry skin, peeling, wrinkling, abnormal pigmentation, and skin cancer. [0003] The sunlight ultraviolet spectrum can be divided into 3 parts: short wave (UVC: 200-280nm), medium wave (UVB: 280-320nm), long wave (UVA: 320-400nm). Among them, due to the absorption of the ozone layer, short-wave rays (UVC) can hardly reach the surface of the earth, so the damage caused by sunlight ultraviolet rays to human skin is mainly caused by the combined effect of medium-wave (UVB) and long-wave (UVA) rays....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61Q17/04A61Q19/00
Inventor 叶希韵刘霞刘雨婷何云东刘明耀
Owner EAST CHINA NORMAL UNIV