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Method for preparing nardostachyos root and rhizome volatile oil beta-cyclodextrin inclusion compound

A technology of cyclodextrin inclusion compound and pine pine volatile oil, which is applied in the field of medicine, can solve the problems of low production efficiency, difficulty in realizing continuous industrial production, and long preparation time, so as to improve stability, increase solubility and bioavailability Effect

Active Publication Date: 2013-03-27
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main purpose of the present invention is to provide a colloid mill preparation method of the inclusion compound of natural Chinese medicine volatile oil-nard pine volatile oil β-cyclodextrin, to overcome the long preparation time and low production efficiency of the existing technology, and it is difficult to realize the continuous chemical industry. production defects

Method used

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  • Method for preparing nardostachyos root and rhizome volatile oil beta-cyclodextrin inclusion compound
  • Method for preparing nardostachyos root and rhizome volatile oil beta-cyclodextrin inclusion compound
  • Method for preparing nardostachyos root and rhizome volatile oil beta-cyclodextrin inclusion compound

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Grind 100mL of pine pine volatile oil, 800g of β-cyclodextrin and 6400mL of water in a circulating grinding inclusion equipment for 10 minutes, then stand at a temperature of 20°C for 24 hours, vacuum filter, and at a temperature of 40°C Drying under a pressure of 0.1 MPa for about 24 hours, the β-cyclodextrin inclusion compound of nard pine volatile oil is obtained.

[0042] Adopt the 2010 edition " Chinese Pharmacopoeia " volatile oil determination method A (appendix XD) to detect, according to calculating, in the nard pine volatile oil β-cyclodextrin inclusion compound, nard pine volatile oil utilization rate (%) is 85.03%, inclusion The recovery rate (%) of the inclusion compound was 92.24%, and the oil content rate (%) of the clathrate was 8.82%.

Embodiment 2

[0044] Grind 100mL of pine pine volatile oil, 800g of β-cyclodextrin and 4800mL of water in a circulating grinding inclusion equipment for 20 minutes, then stand at a temperature of 18°C ​​for 24 hours, vacuum filter, and at a temperature of 40°C Drying under a pressure of 0.1 MPa for about 24 hours, the β-cyclodextrin inclusion compound of nard pine volatile oil is obtained.

[0045]Adopt the 2010 edition " Chinese Pharmacopoeia " volatile oil determination method A (appendix XD) to detect, according to calculating, in the nard pine volatile oil β-cyclodextrin inclusion compound, nard pine volatile oil utilization rate (%) is 87.85%, inclusion The recovery rate (%) of the compound was 88.06%, and the oil content (%) of the clathrate was 9.55%.

Embodiment 3

[0047] Grind 100mL of pine pine volatile oil, 800g of β-cyclodextrin and 6400mL of water in a circulating grinding inclusion equipment for 5 minutes, then let it stand at a temperature of 18°C ​​for 24 hours, vacuum filter, and grind at a temperature of 40°C Drying under a pressure of 0.1 MPa for about 24 hours, the β-cyclodextrin inclusion compound of nard pine volatile oil is obtained.

[0048] Adopt the 2010 edition " Chinese Pharmacopoeia " volatile oil determination method A (appendix XD) to detect, according to calculating, in the β-cyclodextrin inclusion compound of the pine pine volatile oil, the utilization rate (%) of the pine pine volatile oil is 86.26%. The recovery rate (%) of the inclusion compound was 88.80%, and the oil content rate (%) of the clathrate was 9.30%.

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Abstract

The invention discloses a method for preparing a nardostachyos root and rhizome volatile oil beta-cyclodextrin inclusion compound, which comprises: uniformly mixing nardostachyos root and rhizome volatile oil, water and beta-cyclodextrin; grinding, standing, and filtering under vacuum or performing centrifugal separation; and drying under reduced pressure to the nardostachyos root and rhizome volatile oil beta-cyclodextrin inclusion compound. In the nardostachyos root and rhizome volatile oil beta-cyclodextrin inclusion compound prepared by the method disclosed by the invention, the utilization rate of the nardostachyos root and rhizome volatile oil reaches over 70.00 percent, the inclusion compound recovery rate reaches over 85.00 percent, and the oil content in the inclusion compound is8.50 to 10.50 percent. The nardostachyos root and rhizome volatile oil beta-cyclodextrin inclusion compound prepared by the invention can improve the stability of the volatile oil, increase the solubility and bioavailability of the volatile oil and can be prepared into various formulations such as tablet, capsule, grain, bag, aerosol, drop, paste and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a preparation process of an inclusion compound, in particular to a preparation method of a nard pine volatile oil β-cyclodextrin inclusion compound. Background technique [0002] Nardos-tachys chinensis Batal. or Nardos-tachys jatamansi DC. is the dry root and rhizome of the plant Patillaceae Nardos-tachys jatamansi DC. It is mainly distributed in Sichuan, Gansu, Qinghai and Tibet. Gansong, also known as Gansongxiang and Xiangsong, is a seldom-used traditional Chinese medicine; it has a fragrant smell, sweet taste, and warm nature, and returns to the spleen and stomach meridian. Sluggishness, external treatment of toothache, swollen feet. [0003] There have been many reports on the chemical constituents and pharmacological studies of Gansong. The main components of nard pine are sesquiterpenoids, and the volatile oil of nard pine mainly contains terpenes and their oxygen-contain...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K47/40A61P31/04A61P25/20A61P11/06A61P35/00A61P11/14A61K125/00
Inventor 龚慕辛李海亮
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES