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New use of triclosan as synergist of antifungal drug fluconazole

A technology of triclosan and fluconazole, which is applied in the direction of antifungal agents, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as the growth of drug resistance

Inactive Publication Date: 2011-12-14
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, resistance to azoles in clinically infectious fungi is increasing, due to the fact that azoles are bacteriostatic rather than fungicides

Method used

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  • New use of triclosan as synergist of antifungal drug fluconazole
  • New use of triclosan as synergist of antifungal drug fluconazole
  • New use of triclosan as synergist of antifungal drug fluconazole

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Embodiment Construction

[0013] Reference literature (National committee for clinical laboratory standards. Reference method for broth dilution antifungal susceptibility testing of yeast; Approved Standard M27-A. Lancaster Avenue, Villanova. Pennsylvania: CLSI, 1997.1-12); (Odds F C, Synergy, and what the Chequerboard puts between them, J Antimicrob Chemother (2003) 52, 1); (Meletiadis J etc, In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolifican isolates, Antimicrob Agents Chemother. GM etc, Antimicrobial combination. In: Lorian V, editor. Antibiotics in Laboratory Medicine, 4th ed. Baltimore, MD: The Williams and Wilkins Co. (1996) 330-96) and (Quan Hetc, Potent In Vitro Synergism of Fluconazole and Berberine Chloride againstClinical Isolates of Candida albicans Resistant to Fluconazole, Antimicrob Agents Chemother (2006) 50, 1096-99.) method for drug susceptibility experiments and synergistic experiments, the specific operations are as ...

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Abstract

The invention provides a novel application of triclosan as a synergist of an antifungal agent fluconazole, wherein fungi are Candida albicans. Through the standard microdilution method drug susceptibility tests recommended by CLSI (Clinical Laboratory and Standards Institute), in combination with checkerboard microdilution method, time-kill curve, in vitro agar diffusion tests and other series methods, the study evaluates the in vitro sensitivity of triclosan to clinically-isolated drug-resistant Candida albicans, and meanwhile evaluates the in vitro synergetic action of triclosan and fluconazole against clinically drug-resistant fungi.

Description

technical field [0001] The invention relates to the application of triclosan and fluconazole in combination to enhance the antifungal effect of fluconazole. Background technique [0002] At present, it is believed that there are more than 300 kinds of fungi that harm humans and cause diseases. In the past two decades, fungal infections that have seriously endangered human life and health have been increasing both in terms of incidence and types of infections, especially in immunosuppressed patients. Among human fungal infections, the most important opportunistic pathogen is Candida albicans (C. albicans), which can cause from chronic skin infections to life-threatening systemic fungal infections. Pathogenic fungi not only have the general characteristics of fungi, but also from the perspective of medical microbiology, they are usually a type of fungi that can invade the human body and cause diseases in superficial and deep tissues. In addition, some fungi can also stimulat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4196A61K31/085A61P31/10
Inventor 于录邓旭明郭娜金晶梁俊超李蕾
Owner JILIN UNIV