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Method for producing platycodon root fluidextract

A technology of Platycodon grandiflora fluid extract and Platycodon grandiflorum, which is applied in the field of preparation of traditional Chinese medicine preparations, can solve the problems of low recovery rate of active ingredients, volatile loss of ethanol, long production cycle, etc., to shorten the production cycle, save dosage, and improve extraction efficiency Effect

Active Publication Date: 2013-04-17
TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The percolation method is used to extract the active ingredients of Platycodon grandiflorum in the above method, but there are problems such as cumbersome process, long production cycle, easy volatilization loss of ethanol during the percolation process, resulting in concentration changes, low recovery rate of active ingredients, etc.

Method used

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  • Method for producing platycodon root fluidextract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] a. Crush bellflower into coarse powder and set aside;

[0024] b. Add 50% ethanol equivalent to 5.5 times the weight of bellflower in the batching tank; switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, and pump the 50% ethanol in the batching tank into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate flows back into the batching tank, add the bellflower coarse powder obtained in step a into the batching tank at a constant speed, after the addition, the diaphragm filter press cycle extracts for 40 minutes, and then switch the three-way valve Go to the position of the filtrate storage tank for the first diaphragm press filtration, collect the first filtrate according to the ratio of 500ml per 1000g of the first batch of bellflowers, and 1000ml of the second and subsequent batches of bellflowers per 1000g, and store i...

Embodiment 2

[0026] a. Crush bellflower into coarse powder and set aside;

[0027] b. Add 50% ethanol equivalent to 5 times the weight of bellflower in the batching tank; switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, pump the 50% ethanol in the batching tank into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the press filtrate flows back into the batching tank, add the bellflower coarse powder obtained in step a to the batching tank at a constant speed, after the addition, the membrane filter press cycle extracts for 50 minutes, and then switch the three-way valve Go to the position of the filtrate storage tank for the first diaphragm press filtration, collect the first filtrate according to the ratio of 500ml per 1000g of the first batch of bellflowers, and 1000ml of the second and subsequent batches of bellflowers per 1000g, and store it in ano...

Embodiment 3

[0029] a. Crush bellflower into coarse powder and set aside;

[0030] b. Add 50% ethanol equivalent to 7 times the weight of Bellflower in the batching tank; switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, pump the 50% ethanol in the batching tank into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate returns to the batching tank, add the bellflower coarse powder obtained in step a to the batching tank at a constant speed, after the addition, the diaphragm filter press cycle extracts for 30 minutes, and then switch the three-way valve Go to the position of the filtrate storage tank for the first diaphragm press filtration, collect the first filtrate according to the ratio of 500ml per 1000g of the first batch of bellflowers, and 1000ml of the second and subsequent batches of bellflowers per 1000g, and store it in another ...

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Abstract

The invention discloses a method for producing a platycodon root fluidextract. The invention employs an integrated technology of diagram press filtration, circulated extraction and separation for substituting a percolation method to produce the platycodon root fluidextract. The method for producing platycodon root fluidextract is capable of simplifying the technology flow, greatly shortening the production period, favorably protecting the environment and using the waste residue, reducing the usage amount of an extraction solvent ethanol and greatly raising the recovery rate of the effective component.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of a traditional Chinese medicine preparation. Background technique [0002] Ministry of Health drug standard WS3-B-2205-96 records: Platycodon grandiflora liquid extract is an antitussive and expectorant drug. Its prescription is Platycodon grandiflorum 1000g, 55% ethanol amount. Its preparation method is to pulverize platycodon root into coarse powder, use 55% ethanol as solvent, soak for 48 hours, slowly percolate at a speed of 1-3ml per minute, collect 850ml of initial percolation liquid, store in another device, continue percolation, When the soluble components are completely drained out, collect the subsequent eluting liquid, filter, evaporate at a low temperature below 60°C until it becomes a thick paste, add the initial eluting liquid, mix, add 55% ethanol to make 1000ml, mix well, stand for several days, filter Pass, that is. In the above method, the percolat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/34A61K9/06A61P11/10A61P11/14
Inventor 冯天炯黄珠成邓大用贺礼文徐慧
Owner TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD