Determination method of carthamus tinctorius extract

Abstract

The invention provides a determination method of a carthamus tinctorius extract. A least squares support vector machine theory and a near infrared spectrum technology are combined, and a particle swarm optimization is used for parameter optimization on LS-SVM, so as to establish a quantitative analytical mode of amount of solid and hydroxyl safflower yellower A during a carthamus tinctorius extraction and realize rapid determination of key indexes of the amount of solid and a hydroxyl safflower yellower A concentration during the safflower extraction. The mode established on least squares support vector machine of particle swarm optimization of the invention has advantages of good stability, high degree of forecast accuracy and strong extrapolation and generalization capability. Compared with a traditional analysis method, the established analysis method is rapid and effective, and can be used for rapid determination of solid amount and hydroxyl safflower yellower A concentration during a carthamus tinctorius extraction. The invention is conducive to increase of quality control level during safflower extraction, so as to ensure stable and reliable product quality. The method of the invention has advantages of simple operation, strong model prediction capability, high stability, and strong extrapolation and generalization capability.

Description

technical field [0001] The invention belongs to the field of near-infrared detection, and in particular relates to a rapid determination method of safflower extract based on particle swarm optimization and least squares support vector machine algorithm. Background technique [0002] The main component of safflower injection is safflower extract (Carthamus tinctorius L.), which has the functions of anticoagulant, antithrombotic, dilating blood vessels and effectively preventing and treating cardiovascular and cerebrovascular diseases. Hydroxysafflor yellow A (Hydroxysafflor yellow A) is the main active ingredient of safflower. Pharmacological experiments have proved that HSYA can significantly improve hypoxia tolerance, dilate coronary arteries, increase coronary flow, and significantly inhibit platelet aggregation. The extraction process is the starting point of the production process of safflower injection, which is directly related to the utilization rate of safflower medi...

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Problems solved by technology

However, the modeling algorithms used in these patents and documents are partial least squares regression, and the least squares support vector machine (PSO-LS-SVM) algorithm based on particle swarm optimization (PSO-LS-SVM) algorithm for the determination of key indicators in the production process of traditional Chinese medicine has not yet been established. see related reports

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