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Application of dendrobium candidum to preparation of medicine for treating intestinal metaplasia

A technology of Dendrobium officinale and intestinal metaplasia, which is applied in the application field of medicine and achieves remarkable effect.

Active Publication Date: 2012-01-25
ZHEJIANG TIANHUANG MEDICINAL PLANT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the prescriptions of Chinese patent medicines are mostly qi-regulating, spleen-strengthening, and eliminating-guiding medicines, especially those that have a better effect on gastric mucosal intestinal metaplasia need to be researched and discovered.

Method used

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  • Application of dendrobium candidum to preparation of medicine for treating intestinal metaplasia
  • Application of dendrobium candidum to preparation of medicine for treating intestinal metaplasia
  • Application of dendrobium candidum to preparation of medicine for treating intestinal metaplasia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] [Example 1] Preparation of Tiepi Fengdou Granules (P)

[0021] (1) Weigh 1670g of Tiepi Fengdou and 1330g of American ginseng according to the prescription ratio, and set aside.

[0022] (2) Soak Tiepi Fengdou medicinal material in 30 times warm water for half an hour, heat extraction 3 times, 8 hours each time. After each extraction, the extract was centrifuged and filtered, and the filtrates were combined three times to obtain the extract. The extract is concentrated under reduced pressure to a concentrated solution with a relative density of 1.00-1.20 (60-70° C.) for later use.

[0023] (3) American ginseng is placed in a multifunctional extraction tank, extracted 3 times with 70% ethanol under reflux, each time for 3 hours, the extracts are combined, ethanol is recovered under reduced pressure, concentrated under reduced pressure to a relative density of 1.00-1.15 (20-25 ℃) concentrated solution, for later use.

[0024] (4) Combine the above-mentioned Tiepi Fengd...

Embodiment 2

[0025] [Example 2] Preparation of Tiepi Fengdou Granules (L)

[0026] (1) Weigh 1200g of Tiepi Fengdou and 1800g of American ginseng according to the prescription ratio, and set aside.

[0027] (2) Soak Tiepi Fengdou medicinal material in 30 times warm water for half an hour, heat extraction 3 times, 8 hours each time. After each extraction, the extract was centrifuged and filtered, and the filtrates were combined three times to obtain the extract. The extract is concentrated under reduced pressure to a concentrated solution with a relative density of 1.00-1.20 (60-70° C.) for later use.

[0028] (3) American ginseng is placed in a multifunctional extraction tank, extracted 3 times with 70% ethanol under reflux, each time for 3 hours, the extracts are combined, ethanol is recovered under reduced pressure, concentrated under reduced pressure to a relative density of 1.00-1.15 (20-25 ℃) concentrated solution, for later use.

[0029] (4) Combine the above-mentioned Tiepi Fengd...

Embodiment 3

[0030] [Example 3] Preparation of Tiepi Fengdou Granules (H)

[0031] (1) Weigh 1800g of Tiepi Fengdou and 1200g of American ginseng according to the prescription ratio, and set aside.

[0032] (2) Soak Tiepi Fengdou medicinal material in 30 times warm water for half an hour, heat extraction 3 times, 8 hours each time. After each extraction, the extract was centrifuged and filtered, and the filtrates were combined three times to obtain the extract. The extract is concentrated under reduced pressure to a concentrated solution with a relative density of 1.00-1.20 (60-70° C.) for later use.

[0033] (3) American ginseng is placed in a multifunctional extraction tank, extracted 3 times with 70% ethanol under reflux, each time for 3 hours, the extracts are combined, ethanol is recovered under reduced pressure, concentrated under reduced pressure to a relative density of 1.00-1.15 (20-25 ℃) concentrated solution, for later use.

[0034] (4) Combine the above-mentioned Tiepi Fengd...

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PUM

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Abstract

The invention relates to a novel purpose of dendrobium candidum, which aims at providing an application of the dendrobium candidum to the preparation of medicine for treating intestinal metaplasia. The invention discloses the application of the dendrobium candidum to the preparation of the medicine for treating the intestinal metaplasia and a preparation method of the medicine for treating the intestinal metaplasia on the basis of the dendrobium candidum. Both dendrobium candidum particles provided by the invention and Yangweishu particles have a certain reversing effect on the intestinal metaplasia caused by N- methyl-N'-nitryl-N-nitrosoguanidine (MNNG), but the effect of the dendrobium candidum particles is more obvious. Results show that the dendrobium candidum particles mixed with American ginseng has the potential application prospects on the intestinal metaplasia of clinic chronic atrophic castritis (CAG).

Description

technical field [0001] The invention relates to a new application of dendrobium candidum, in particular to an application of dendrobium candidum in preparing medicine for treating intestinal metaplasia. Background technique [0002] Chronic atrophic gastritis (CAG) is a common and frequently occurring disease, characterized by atrophy of gastric mucosal epithelium and glands, mucosal thinning, thickening of submucosal muscular layer, intestinal metaplasia, and atypical hyperplasia , the course of the disease is protracted, often shows effect repeatedly, has a strong impact on the patient's work and physical and mental health. More importantly, since CAG intestinal metaplasia and atypical hyperplasia are very likely to further develop into gastric cancer, the World Health Organization (WHO) listed CAG gastric mucosal atrophy, intestinal metaplasia and atypical hyperplasia in 1978. precancerous lesion of gastric cancer. According to statistics, the incidence rate of CAG in m...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P1/04
Inventor 杨兵勋吴人照夏克中沈春香张旭峰陈武兵杨芳亮楼正家陈立钻
Owner ZHEJIANG TIANHUANG MEDICINAL PLANT PHARMA
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