Preparation method of methylsulfonic acid imatinib tablet

A tablet-forming technology of imatinib mesylate, which is applied in the field of preparation of tablets containing imatinib mesylate, and can solve problems such as low dissolution and difficult dissolution of raw materials

Inactive Publication Date: 2012-02-15
ZHEJIANG HUAHAI PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, it was found that there was a problem of low dissolution
This may be due to the accumulation o

Method used

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  • Preparation method of methylsulfonic acid imatinib tablet
  • Preparation method of methylsulfonic acid imatinib tablet
  • Preparation method of methylsulfonic acid imatinib tablet

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Abstract

The invention discloses a preparation method of methylsulfonic acid imatinib tablet. The invention takes organic solvent or organic solution with volume concentration bigger than 70% as pelletization solution, and the weight of water-insoluble filling agent in the tablet accounts for less than 20% of the total weight of the tablet. The invention has advantages of simple technical process, high yield and good dissolution of a product.

Description

technical field The invention relates to a preparation method of a tablet containing imatinib mesylate. Background technique Imatinib mesylate, developed by Novartis, is the world's first approved inhibitor of tumorigenesis-related signal transduction. Its chemical name is: 4-[(4-methyl-1-piperazine)methyl]-N-[4-methyl-3-[[4-(3-pyridine)-2-pyrimidine]amino]benzene base]-aniline methanesulfonate. Molecular formula: C 29 h 31 N 7 O·CH 4 SO 3 Molecular weight: 589.7 The simplified structure is: WO2009 / 042803 discloses the technology of producing imatinib mesylate tablets by dry granulation process, and the ratio of its raw material drug is 23-29%. EP1762230B1 protects the process of producing coated tablets, mainly dry granulation process, and the amount of API is between 25-80%. The production of imatinib mesylate tablets by dry granulation has certain defects in commercial production. Relatively speaking, the amount of dust generated in the dry granulation pr...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/506A61P35/00
Inventor 彭俊清代孔恩魏芳胡李斌李巧霞胡功允
Owner ZHEJIANG HUAHAI PHARMACEUTICAL CO LTD
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