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Granulating method of gel and gel granulating equipment

A technology before gel and granulation, applied in the field of sieve granulation, can solve the problems that it is difficult to control the particle size and particle uniformity of the product, and affect the yield, so as to achieve narrow gel particle size distribution, high production efficiency, The effect of simple structure

Active Publication Date: 2013-03-27
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the cryogenic mill reduces the heat generated between the rotor and the material, it is not easy to control the particle size and particle uniformity of the product, and the prepared cross-linked hyaluronic acid particles have a wide range, which affects the yield

Method used

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  • Granulating method of gel and gel granulating equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] use as figure 1 Gel granulation equipment to prepare cross-linked sodium hyaluronate gel particles.

[0032] A pre-granulation tank 1, a plunger pump or a diaphragm pump 2, a sleeve 4 and a post-granulation tank 5 are sequentially connected through pipelines. Two layers of 400-mesh granulation screens 3 for granulation are installed in the casing 4, and one layer of 600-mesh grading screens 6 for filtration is installed at the bottom of the tank 5 after granulation.

[0033] Put the preliminarily broken cross-linked hyaluronic acid gel into the pre-granulation tank 1, turn on the plunger pump or diaphragm pump 2, pump the gel from the pre-granulation tank to the casing, and successively pass through the 2-layer granulation The sieve completes the granulation, and then enters the post-granulation tank, and the grading sieve filters out fine particles to obtain gel particles with a relatively uniform particle size. The particle size and uniformity were observed under a ...

Embodiment 2

[0037] A 100-mesh granulation screen for granulation is installed in the casing, and a 150-mesh grading screen for filtration is installed in the tank after granulation. Turn on the plunger pump or diaphragm pump, extract the gel from the tank before granulation, granulate during the extraction process, and guide it to the tank after granulation. The fine particles are filtered out by the grading screen to obtain gel particles. Observe the particle size and uniformity under a sampling microscope, and the particle size is between 100-160 μm.

[0038] Others are basically the same as in Example 1.

Embodiment 3

[0040] An 80-mesh granulation screen for granulation is installed in the casing, and a 90-mesh grading screen for filtration is installed in the tank after granulation. Turn on the plunger pump or diaphragm pump, extract the gel from the tank before granulation, granulate during the extraction process, guide it to the tank after granulation, and filter out fine particles with a grading screen to obtain gel particles. The particle size and uniformity were observed under a sampling microscope, and the particle size was between 160-250 μm.

[0041] Others are basically the same as in Example 1.

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Abstract

The invention relates to a granulating method of gel, and specifically relates to a granulating method powered by a plunger pump or a diaphragm pump and using a screen mesh, and gel granulating equipment employing the method. The granulating method comprises steps that the gel is placed in a granulating front tank; the gel in the granulating front tank is powered by the plunger pump or the diaphragm pump to pass through a sleeve pipe equipped with as least one layer of a granulating screen mesh; and the gel is granulated and conveyed into a rear tank continuously. The granulating method of the present invention has characteristics of rapid granulating, enclosing granulating process and narrow particle size distributing scope, and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a gel granulation method, in particular to a method for granulation by using a plunger pump or a diaphragm pump to provide power, and a sieve; and gel granulation equipment using the method. Background technique [0002] Sodium hyaluronate is a natural straight-chain polysaccharide. Sodium hyaluronate and sodium hyaluronate gel obtained by mild cross-linking have good biocompatibility in the human body, and are widely used in medicine, plastic surgery, and cosmetics. industry. [0003] Cross-linked sodium hyaluronate gel is a water-insoluble gel with a certain degree of elasticity, and is usually made into particles of a certain particle size for use. At present, most gel granulation methods use electric stirrer stirring, sample milling, cryogenic milling and manual sieving, and most of them are open operations, which are easily polluted by dust particles and microorganisms in the environment. [0004] The patent publicat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/00B01J2/20
Inventor 郭学平刘建建付杰栾贻宏
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD