Morphological analytical apparatus and method for erythrocytes

A morphological analysis, red blood cell technology, applied in the direction of material analysis, measurement device, analysis material, etc. by optical means, can solve the problems of heavy workload, slow speed, delay in patient diagnosis, etc., to achieve the effect of reducing the effect of errors

Active Publication Date: 2012-02-22
AVE SCI & TECH CO LTD
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Problems solved by technology

However, the manual microscopic examination method has a large workload for the staff, and it is easy to cause ...

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  • Morphological analytical apparatus and method for erythrocytes
  • Morphological analytical apparatus and method for erythrocytes
  • Morphological analytical apparatus and method for erythrocytes

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Embodiment Construction

[0063] figure 1 It is a schematic diagram of the red blood cell morphology analysis device of the present invention. As shown in the figure, the red blood cell morphology analysis device of the present invention includes:

[0064] a. An automatic microscope 1, the low magnification objective lens of the automatic microscope 1 first scans the sample in the set area, and marks the target area found, and at the same time the marked area is scanned by the high magnification objective lens of the automatic microscope 1 The sample is scanned;

[0065] b. A camera or CCD element 2, which collects image information on the marked area sample;

[0066] c. an image digital converter 3 for generating digital representations of the above images, the image digital converter 3 first segments and positions the collected images according to the cells contained in them, and then digitizes the segmented images, that is, extracts each Cell size, shape, chromaticity and texture four types of mo...

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Abstract

The invention discloses a morphological analytical apparatus and method for erythrocytes. According to the invention, a sample is placed under an automatic microscope and amplified, morphological images of all the cells in the sample are collected by a CCD (charge-coupled device) and digitalized by an image digitizer, and then segmentation and positioning of the images and extraction of target characteristic parameters are carried out; morphological characteristic parameters of every erythrocyte are separated with a classifier established on the basis of a neural network; normalization treatment is carried out on morphological characteristic parameter data of every variety of erythrocytes with a characteristic fusion cage established on the basis of fuzzy clustering; statistical analysis is carried out on each variety of obtained normalization parameters; comprehensive statistical analysis is carried out on a plurality of the normalization parameters and is expressed with figures or numerical tables so as to determine whether morphology of the erythrocytes is normal; and sources and properties of the erythrocytes can be identified through detection of erythrocytes with abnormal morphology.

Description

technical field [0001] The invention relates to a red blood cell morphology analysis device and method in a sample, in particular to a red blood cell morphology analysis device and method capable of automatically identifying the type and source of red blood cells contained in a sample. Background technique [0002] As early as 1852, someone began to design a method for counting red blood cells, and in 1855, a counting board for counting red blood cells was invented. In 1947, American scientist W.H. Coulter invented the patented technology of counting particles by resistance method. And in 1956, this technology was successfully applied to red blood cell counting. With the rapid development of science and technology, various new means of detecting the number of red blood cells are constantly emerging. The currently applied research and development methods mainly include: capacitive, photoelectric and laser, centrifugal, resistive and various combined methods. So far, many c...

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Application Information

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IPC IPC(8): G01N21/17G01N21/27G06N3/02
Inventor 丁建文周丰良梁光明
Owner AVE SCI & TECH CO LTD
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