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Dexibuprofen injection and preparation method thereof

A technology for preparation of injections and Dexibuprofen, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as instability, avoid degradation, and increase solubility , the effect of increasing solubility

Inactive Publication Date: 2012-02-29
陆荣政
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since Dexibuprofen is almost insoluble in water, it is only easily soluble in alkaline medium, but similar to ibuprofen, it is unstable in alkaline medium, and its specific impurity, 4-isobutyl ethyl ketone, increases rapidly

Method used

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  • Dexibuprofen injection and preparation method thereof
  • Dexibuprofen injection and preparation method thereof
  • Dexibuprofen injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0015] prescription:

[0016]

[0017] Preparation process: Dissolve dexibuprofen 200g, meglumine 400g, citric acid 200g, and trisodium citrate 100g in water for injection, add water for injection to the required amount; filter the solution with a 0.22um filter membrane, fine filter After filling and sealing in ampoules, 121 ° C damp heat sterilization for 10 minutes, to obtain Dexibuprofen injection.

Embodiment 2

[0019] prescription:

[0020]

[0021] Preparation process: Dissolve dexibuprofen 400g, meglumine 800g, citric acid 400g, and trisodium citrate 200g in water for injection, add water for injection to the required amount; filter the solution with a 0.22um filter membrane, fine filter After filling and sealing in ampoules, 121 ° C damp heat sterilization for 10 minutes, to obtain Dexibuprofen injection.

[0022] Study on Stability of Dexibuprofen Injection

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Abstract

The invention discloses dexibuprofen injection and a preparation method thereof. The invention is characterized in that the injection is preparation which is prepared by using dexibuprofen as the main ingredient. The preparation consists of dexibuprofen, meglumine, citric acid and trisodium citrate. The pH value of the solution is 5.0 to 7.0. The preparation has the advantages that: dexibuprofen acts quickly and is absorbed quickly; the medicinal liquid directly enters blood circulation without being affected by the digestion system and foods; and the like. The stability of the injection is high.

Description

technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, and relates to a new dosage form of ibuprofen, in particular to an injection of ibuprofen and a preparation method thereof. Background technique [0002] Non-steroidal anti-inflammatory drugs (NSAIDs) have good anti-inflammatory, antipyretic and analgesic effects, and are widely used to treat arthritis (especially RA, OA) and pain caused by various inflammations. Ibuprofen was first launched in the UK in 1968. Due to its significant antipyretic and analgesic effects and low toxicity, it is better than aspirin and paracetamol. It has been widely used as a non-steroidal anti-inflammatory drug, and the market has expanded rapidly. Due to the better curative effect and less adverse reactions of ibuprofen, the United States and the United Kingdom have successively approved the conversion of ibuprofen from prescription drugs to over-the-counter drugs. By the early 1990s, the sales of ibupro...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/192A61K47/26A61K47/12A61P29/00
Inventor 陆荣政徐卓业文意芬
Owner 陆荣政
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