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Method for improving transfer rate of chrysophanol

A technology of transfer rate and chrysophanol, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of low transfer rate and achieve the effect of improving transfer rate.

Active Publication Date: 2012-04-11
SHANGHAI JINGFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of this invention is to provide a kind of method that improves chrysophanol transfer rate, to overcome the low problem of transfer rate existing in the method for transferring chrysophanol

Method used

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  • Method for improving transfer rate of chrysophanol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prepare 1000ml of ethanol solution with a concentration of 60% by weight, add a little sodium hydroxide to make the solution pH=9; weigh 6.2g of 20-mesh rhubarb powder, pour the rhubarb powder into the ethanol solution, stir for 30 minutes, and start to soak for 40 hours. Stir twice in the middle, 30 minutes each time. Filter and pour out the leachate, and send it to QC for inspection. Test result is: chrysophanol content is 24.4ug / ml.

Embodiment 2

[0020] Prepare 1000ml of ethanol solution with a weight percent concentration of 95%, add a little sodium hydroxide to make the solution pH=11; weigh 6.2g of 20-mesh rhubarb powder, pour the rhubarb powder into the ethanol solution, stir for 30 minutes, and start to soak for 40 hours. Stir twice in the middle, 30 minutes each time. Filter and pour out the leachate, and send it to QC for inspection. The test result is: the chrysophanol content is 24.6ug / ml.

Embodiment 3

[0022] Prepare 1000ml of ethanol solution with a weight percent concentration of 50%, add a little sodium hydroxide to make the solution pH=8.5; weigh 6.2g of 20-mesh rhubarb powder, pour the rhubarb powder into the ethanol solution, stir for 30 minutes, and start to soak for 40 hours. Stir twice in the middle, 30 minutes each time. Filter and pour out the leachate, and send it to QC for inspection. Test result is: chrysophanol content is 24.2ug / ml.

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Abstract

The invention relates to a method for improving the transfer rate of chrysophanol. The method comprises the step of carrying out discontinuous stirring on screened rhubarb powder in a 50-95% alcohol water solution at a pH value of 8.5-11. The method effectively improves the transfer rate of chrysophanol transferred from rhubarb powder.

Description

technical field [0001] The invention relates to a drug transfer method, in particular to a method for improving the transfer rate of chrysophanol. Background technique [0002] Chrysophanol is the main active ingredient of rhubarb powder. Traditional Chinese medicine rhubarb has the functions of attacking stagnation, clearing damp and heat, purging fire, cooling blood, removing blood stasis, and detoxifying. Rhubarb powder is the main medicinal material in the analgesic and active tincture. It is also an ingredient that clearly stipulates the content in the quality standard of Analgesic Huoluo Tincture. "The Pharmacopoeia of the People's Republic of China" stipulates that the content of chrysophanol in the analgesic and active collateral tincture is ≥10ug / ml. [0003] Analgesic Huoluo Tincture is a traditional Chinese medicine preparation, which has been clinically used for many years and has a good curative effect. Analgesic Huoluo Tincture currently on the market is mai...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K9/08A61P29/00A61P19/00
Inventor 马贤鹏张永钱正祥
Owner SHANGHAI JINGFENG PHARMA
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