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Medicament for treating HPV infection and application of medicament in preparation of medicament for treating HPV infection

A drug and pharmacy technology, applied in the field of biomedicine, can solve the problems that no human rabies vaccine treatment reports have been retrieved, and achieve the effect of not being easy to relapse

Inactive Publication Date: 2012-04-18
LIAONING CHENGDA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Yet the present inventor has not yet retrieved the treatment report of human rabies vaccine to HPV infection

Method used

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  • Medicament for treating HPV infection and application of medicament in preparation of medicament for treating HPV infection
  • Medicament for treating HPV infection and application of medicament in preparation of medicament for treating HPV infection
  • Medicament for treating HPV infection and application of medicament in preparation of medicament for treating HPV infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: use rabies virus PV-2061 strain to produce human rabies vaccine

[0021] Rabies virus PV-2061 strain, inoculated in eukaryotic cells (including Vero cells, hamster kidney cells, human diploid cells, chicken embryo cells, preferably Vero cells), harvested virus liquid, inactivated, purified, added The pharmaceutically acceptable carrier is used to prepare rabies vaccine preparations for adults, and the dose is 0.5-10.5 IU / dose.

Embodiment 2

[0022] Embodiment 2: Production of human rabies vaccine with rabies virus PM strain

[0023] The PM strain of rabies virus is inoculated in eukaryotic cells (including Vero cells, hamster kidney cells, human diploid cells, chicken embryo cells, preferably human diploid cells), and the virus liquid is harvested, inactivated and purified. A pharmaceutically acceptable carrier is added to prepare a rabies vaccine preparation for adults, 0.5-10.5 IU / dose.

Embodiment 3

[0024] Embodiment 3: use rabies virus Vnukovo-32 strain to produce human rabies vaccine

[0025] Rabies virus Vnukovo-32 strain, inoculated in eukaryotic cells (including Vero cells, hamster kidney cells, human diploid cells, chicken embryo cells, preferably hamster kidney cells), harvested virus fluid, inactivated, and purified , adding a pharmaceutically acceptable carrier to prepare a rabies vaccine preparation for adults, 0.5-10.5 IU / dose.

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Abstract

A medicament for treating HPV infection and an application of the medicament in the preparation of medicaments for treating HPV infection. The invention is characterized in that the active component of the medicament is rabies vaccine for human, and a pharmaceutically-acceptable carrier is added to prepare the medicament; the invention also provides an application of the medicament in the preparation of medicaments for treating HPV infection, that is, a new application of rabies vaccine for human in the preparation of medicaments for treating human papillomavirus infection. The medicament (rabies vaccine for human) for treating human papillomavirus infection provided by the invention has obvious treatment effect on human papillomavirus infection; through animal experiments and preclinical observation, the medicament has satisfied and beneficial effect, has the characteristics of safety, effectiveness, and difficult recurrence after cure, and has a treatment negative conversion rate of up to 90% for human papillomavirus infection positive patients.

Description

technical field [0001] The present invention relates to a biological product, in particular to a medicine for treating human papillomavirus (HPV) infection containing human rabies vaccine, and the use of human rabies vaccine in the preparation of medicine for treating human papillomavirus (HPV) infection The application belongs to the technical field of biomedicine. Background technique [0002] Human papillomavirus (HPV) belongs to the Papillomavirus genus of the Papillomaviridae family, and is a spherical non-enveloped small double-stranded circular DNA virus. More than 120 types have been found so far. HPV can be divided into high-risk and low-risk types according to whether it causes cancer. An epidemiological classification study in 2003 defined 15 high-risk HPV types (such as HPV-16, HPV-18) and 12 low-risk HPV types (such as HPV-6, HPV-11). [0003] HPV is a relatively common virus that spreads widely in the population, because most HPV infections cause no symptoms...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/205A61P31/20
CPCC12N2710/20034A61K39/205A61K2039/585A61K39/12C12N2760/20134A61K2039/5252A61K2039/541A61K2039/55505A61K2039/70A61P31/20
Inventor 高军赵维诚白珠穆赵会林张庆义于海春杨俊伟孙非非
Owner LIAONING CHENGDA BIOTECH
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