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Synthetic method of lambdacyhalothrin hapten

A technology of kungfu pyrethroid and synthesis method, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., to achieve the effect of safe and feasible synthesis steps

Inactive Publication Date: 2012-04-18
王利兵 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no active groups such as —COOH, —NH 2 , -OH or -SH, etc. Therefore, in order to realize the coupling of kurathrin and carrier protein, the design and synthesis of kurathrin hapten should be carried out first

Method used

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  • Synthetic method of lambdacyhalothrin hapten
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  • Synthetic method of lambdacyhalothrin hapten

Examples

Experimental program
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Embodiment 1

[0032] (1) Synthesis of benzyl 4-hydroxyphenylpropionate (compound 1)

[0033] In a 100 mL round bottom flask, add 5.0 g (30.1 mmol) p-hydroxyphenylpropionic acid, 3.4 g (34.0 mmol) potassium bicarbonate (KHCO 3 ), 15mL N,N'-dimethylformamide (DMF), and then add 8.0g (46.8mmol) benzyl bromide (BnBr), and stir at room temperature overnight. After the reaction, the reaction solution was diluted with ethyl acetate, and then with saturated NaHCO 3 Wash 3 times, wash 2 times with distilled water, and finally wash 2 times with saturated saline. The organic phase was dried, concentrated, and purified by column chromatography to obtain 6.9 g of benzyl 4-hydroxyphenylpropionate, a colorless viscous liquid, with a yield of about 89.4%.

[0034] (2) Synthesis of 3-(dimethoxymethyl)bromobenzene (compound 2)

[0035] Add 7.4g (40.0mmol) m-bromobenzaldehyde, 17.0g (160.0mmol) trimethyl orthoformate, 74mg (0.4mmol) p-toluenesulfonic acid into a 100mL round bottom flask, then heat and sti...

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Abstract

A synthetic method of a lambdacyhalothrin hapten belongs to the technical field of biochemical engineering. A raw material of hydroxyphenylpropionic acid is treated with seven steps of chemical reactions to obtain the lambdacyhalothrin hapten; and a liquid chromatography-mass spectrometry technology and a nuclear magnetic resonance technology are employed to identify and analyze important intermediates and end products. According to the invention, lambdacyhalothrin hapten is synthesized successfully; synthesis steps are safe and effective; therefore, the invention provides favorable conditions for establishing ELISA method of lambdacyhalothrin and satisfies domestic requirements on the research.

Description

technical field [0001] The invention discloses a method for synthesizing the hapten of kaufenthrin, which belongs to the field of biochemical technology. Background technique [0002] Kungfuthrin, also known as cyhalothrin, is an important pyrethroid insecticide, and its chemical structure is as follows: [0003] [0004] It has the advantages of high efficiency, low residue and wide insecticidal spectrum, and is widely used in agricultural production such as tea and fruit trees. With the prohibition of highly toxic organophosphorus pesticides, the use of Class II pyrethroids, including Kungfuthrin, has increased rapidly, causing the problem of pesticide residues in agricultural products to be more and more serious; in addition, in aquatic animals, there will be The accumulation of residues will indirectly affect human safety. In recent years, the Food and Agriculture Organization of the United Nations and the World Health Organization (FAO / WHO) have provided strict r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C255/39C07C253/30
Inventor 王利兵胥传来陈秀金
Owner 王利兵
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