Method for producing D-p-hydroxyphenylglycine

A technology for p-hydroxyphenylglycine and p-hydroxyphenylhydantoin, which is applied in the field of producing D-p-hydroxyphenylglycine, can solve the problems of long reaction time, complicated process, low yield and the like, and achieves short reaction time, simple process and high yield. high rate effect

Inactive Publication Date: 2012-05-16
HENAN NEWLAND PHARMA
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the prior art, the method for producing D-p-hydroxyphenylglycine from p-hydroxyphenylhydantoin is: chemically catalyzed hydrolysis of p-hydroxyphenylhydantoin to generate D-L-p-hydroxyphenylglycine, and finally obtained by resolution or induced crystallization D-p-hydroxyphenylglycine; or directly from p-hydroxybenzene through the action of biological enzymes, has the disadvantages of complex process, low yield and long reaction time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] a, prepare 100 kilograms of 5% sodium chloride aqueous solution, adjust to PH=0 with hydrochloric acid, for subsequent use;

[0009] b. Add 30 kg of DL-p-hydroxyphenylhydantoin with the mass of the above solvent, and stir for 2 hours at a temperature of 60° C.; c. Filter to obtain D-p-hydroxyphenylglycine.

[0010] The obtained D-p-hydroxyphenylglycine is 27.5 kilograms, and the process is simple and meets the production requirements.

Embodiment 2

[0012] a, prepare 100 kilograms of 7% sodium chloride aqueous solution, adjust to PH=3 with phosphoric acid, for subsequent use;

[0013] b. Add 40 kg of DL-p-hydroxyphenylhydantoin with the mass of the above solvent, and stir for 3 hours at a temperature of 70° C.; c. Filter to obtain D-p-hydroxyphenylglycine.

[0014] The obtained D-p-hydroxyphenylglycine is 37 kilograms, and the process is simple, which meets the production requirements.

Embodiment 3

[0016] a, prepare 100 kilograms of 6% sodium chloride aqueous solution, adjust to PH=2 with hydrochloric acid, for subsequent use;

[0017] b. Add 35 kg of DL-p-hydroxyphenylhydantoin with the mass of the above solvent, and stir for 2.5 hours at a temperature of 65° C.; c. Filter to obtain D-p-hydroxyphenylglycine.

[0018] The obtained D-p-hydroxyphenylglycine was 33.3 kg, and the process was simple, which met the production requirements.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of pharmacy and chemical industry, in particular to a method for producing D-p-hydroxyphenylglycine. The method for producing the D-p-hydroxyphenylglycine comprises the following steps of: a, preparing a 5 to 10 percent aqueous solution of sodium chloride, and regulating the pH to be 0-3 by using acid for later use; b, adding DL-p-hydroxyphenylhydantoin in an amount which is 30 to 40 percent based on the mass of the solvent, and stirring at the temperature of between 60 and 70 DEG C for 2 to 3 hours; and c, filtering to obtain the D-p-hydroxyphenylglycine. The method for producing the D-p-hydroxyphenylglycine has the advantages of high yield and short reaction time and is simple.

Description

technical field [0001] The invention relates to the production technical fields of pharmacy and chemical industry, in particular to a method for producing D-p-hydroxyphenylglycine. Background technique [0002] In the prior art, the method for producing D-p-hydroxyphenylglycine from p-hydroxyphenylhydantoin is: chemically catalyzed hydrolysis of p-hydroxyphenylhydantoin to generate D-L-p-hydroxyphenylglycine, and finally obtained by resolution or induced crystallization D-p-hydroxyphenylglycine; or directly from p-hydroxybenzene through the action of biological enzymes, has the disadvantages of complex process, low yield and long reaction time. Contents of the invention [0003] Purpose of the present invention is exactly for above-mentioned shortcoming, provides a kind of method for the production of D-p-hydroxyphenylglycine with simple technique, high yield and short reaction time. [0004] The technical scheme adopted by the present invention is: a method for producing...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/36C07C227/24
Inventor 谢建中张芦苇刘万民
Owner HENAN NEWLAND PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap