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Health food or pharmaceutical composition comprising chestnut shell extract

A composition and technology of chestnut skin, applied in the field of health food or pharmaceutical composition, can solve the problems of patients with atopic dermatitis who cannot suppress itching, discouragement, arrhythmia, etc., and achieve the effect of improving skin barrier damage

Inactive Publication Date: 2012-05-16
AMOREPACIFIC CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, it is known that the first-generation antihistamines are mainly used for systemic administration, but they have anti-parasympathetic effects and show sedative effects. Pruritus in patients with atopic dermatitis (Munday et al., Dermatology, 205, pp40-45, 2002), the use of topical antihistamines in atopic dermatitis is discouraged due to the risk of allergic skin reactions
Ebastine and terfenadine, which are second-generation antihistamines without sedative effects, may cause arrhythmia when taken together with drugs that inhibit the activity of cytochrome (cytochrome) P450 (ketoconazole, erythromycin) Qi (Hey et al., Arzneimittelforschung, 46, pp159-163, 1996), causing side effects associated with it

Method used

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  • Health food or pharmaceutical composition comprising chestnut shell extract
  • Health food or pharmaceutical composition comprising chestnut shell extract
  • Health food or pharmaceutical composition comprising chestnut shell extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] [Example 1] Preparation of Chestnut Peel Extract

[0060] 1-1) Preparation of chestnut peel 1,3-butanediol extract

[0061] Using 30% 1,3-butanediol (1,3-butylene glyco1), the chestnut skin was leached for 3 days at room temperature. Next, filtration was performed sequentially with filters having a size of 250 mesh, 3 μm, 1 μm, and 0.5 μm. Then, after standing at 0 to 4° C. for 3 days, it was filtered through filters of 0.5 μm, 0.3 μm, and 0.2 μm in order to obtain chestnut peel 1,3-butanediol extract.

[0062] 1-2) Preparation of Chestnut Bark Ethanol Extract

[0063] Using 70% ethanol, the chestnut skin was leached at room temperature for 3 days. Next, filtration was performed sequentially with filters having a size of 250 mesh, 3 μm, 1 μm, 0.5 μm, 0.3 μm, and 0.2 μm. Then, after concentrating the solution at 60° C., vacuum drying was performed at 30° C. for 18 hours to obtain a chestnut peel ethanol extract in a powder form.

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Abstract

The present invention relates to a health food or pharmaceutical composition for alleviating or suppressing pruritus, comprising chestnut shell extract as an active ingredient. In one example of the present invention, the chestnut shell extract comprised in the health food or pharmaceutical composition of the present invention can suitably be used as the active ingredient of a health food or pharmaceutical composition for alleviating or suppressing pruritus as it has been confirmed that it can exhibit an outstanding effect in alleviating or suppressing pruritus by suppressing the activity of proteinase-activated receptor-2 (PAR-2) which is a source of stimulation in pruritus.

Description

technical field [0001] The present invention relates to health food or pharmaceutical composition containing chestnut skin extract. Background technique [0002] Pruritus is defined as an unpleasant skin sensation that induces the desire to scratch, recognized as a physiological self-defense mechanism such as pain, touch, cold or heat when the skin is exposed to noxious stimuli from the outside. Known to play a role in protecting the skin. [0003] Pruritus is one of the common symptoms that often appear in various skin diseases or systemic diseases. In fact, acute pruritus caused by urticaria and side effects of various drugs can be easily cured, but biliary atresia, Treatment of severe chronic pruritus such as kidney disease or atopy is difficult. [0004] Pruritus is induced by various reasons such as inflammation, cancer, metabolic disease, infection, psychiatric disease, drug administration or stress. In several recent research results, the organic connection and targ...

Claims

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Application Information

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IPC IPC(8): A23L1/30A61P17/00A61P29/00A23L2/52
CPCA23V2002/00A23L1/3002A23L2/02A23L2/52A61K36/185A23V2200/318A23V2200/324A23V2250/21A23V2250/70A23V2250/156A23V2250/032A23V2250/0644A23V2250/60A23V2250/612A23V2250/5118A23V2250/708A23V2250/0642A23V2250/6418A23L33/105A61P17/00A61P17/04A61P17/08A61P29/00A61P37/06A61P37/08A61K36/49
Inventor 沈范金善暎金赫高在濚尹侦训徐姃我尹晙源林庆珉朱泳協朴永镐李昌锡
Owner AMOREPACIFIC CORP
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