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Application of embelin to preparation of medicament for treating autoimmune disease

A technology of autoimmunity and signaling quinone, which is applied in the field of traditional Chinese medicine, can solve the problems such as the unclear influence of autoimmune response T cell subsets, and achieve the effect of inhibiting T cell proliferation, reducing the degree of disease, and reducing the occurrence and development

Active Publication Date: 2013-05-01
TIANJIN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effect of signaloquinone on T cell-mediated autoimmune response and different T cell subsets is still unclear, especially the regulatory effect on the helper T cell TH17 subset of inflammatory response and its mediated EAE. to report

Method used

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  • Application of embelin to preparation of medicament for treating autoimmune disease
  • Application of embelin to preparation of medicament for treating autoimmune disease
  • Application of embelin to preparation of medicament for treating autoimmune disease

Examples

Experimental program
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Effect test

Embodiment 1

[0035] 1.1 Isolation of human peripheral blood mononuclear cells

[0036] (1) Go to the blood bank to get fresh blood (no more than 8 hours). Approximately 40 mL.

[0037] (2) Dilute with 3 times the volume of PBS (the more diluted blood samples, the better the purification of monocytes). Take 15 mL of lymphocyte separation medium Ficoll-Paque into a 50 mL centrifuge tube for a total of 160 mL, incline the centrifuge tube at 45o, absorb 35 mL of diluted blood, and superimpose on the separation liquid along the tube wall at 1 cm above the separation liquid surface. destroy the separation interface. (Divide into 4 tubes, first add 35 mL of blood to each tube of 15 mL of Ficoll-Paque, and then average the remaining blood)

[0038] (3) Centrifuge at 400g at room temperature for 30 minutes, decelerate slowly, and do not set the brake gear.

[0039] (4) Take out the centrifuge tube smoothly, the bottom layer is red blood cells and granulocytes, the middle layer is lymphocyte sep...

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Abstract

The invention discloses an application of embelin to the preparation of a medicament for treating an autoimmune disease. As proved by an experimental result, the embelin can be used for suppressing the differentiation of human immune dendritic cells, the maturity of human immune dendritic cells activated by LPS (Lipopolysaccharide), the antigen uptaking capabilities of immature dendritic cells, the antigen presenting capabilities of mature dendritic cells, cell-T breeder reactions excited by dendritic cells, and the expression of cell factors which are secreted by dendritic cells and are usedfor promoting type 1 and type 17 cell differentiation of auxiliary cells T. Particularly, the embelin can be used for lowering the pathogenic degree of mouse experimental autoimmune encephalomyelitis. The invention relates to preparation of a medicament for suppressing an immune system, which can become a medicament for clinically treating autoimmune inflammatory lesions such as multiple sclerosis, acute disseminated encephalomyelitis and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine application, and relates to the application of traditional Chinese medicine monomer Embelin in the preparation of medicines for treating autoimmune diseases and nervous system inflammatory diseases. Background technique [0002] Dendritic cells (DC) are known to be the most powerful antigen-presenting cells (antigen-presenting cells, APCs) in the body, and they are also the APCs that can directly activate naive T cells. [1] . When inflammation occurs, DC first contacts with the antigen and then captures the antigen. After processing, the antigen peptide is combined with MHC molecules and presented on the surface of other immune cells, causing the secretion of cytokines. Under the joint action of the first and second signals, Activate T lymphocytes to generate a specific immune response; on the other hand, DC can induce the thymus to eliminate self-reactive cells, differentiat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122
Inventor 张荣信薛振毅
Owner TIANJIN MEDICAL UNIV
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