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Process method for catalytic synthesis of poly lactic acid-glycolic acid by using bionic organic guanidinium

A technology for catalyzing lactic acid and glycolic acid with creatinine guanidine chloride, which is applied in the field of medical biodegradable materials, can solve problems such as potential safety hazards, and achieve the effects of simple process operation, excellent biocompatibility and biodegradability, and low cost of raw materials

Inactive Publication Date: 2013-12-11
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of potential safety hazards in the synthetic polylactic acid-glycolic acid material used in the field of human medical use by using stannous chloride as a catalyst in the synthesis of polylactic acid-glycolic acid by the existing polycondensation method, and to provide a bionic Process method for synthesizing polylactic acid-glycolic acid by direct co-condensation method catalyzed by type organic guanidinium salt

Method used

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  • Process method for catalytic synthesis of poly lactic acid-glycolic acid by using bionic organic guanidinium
  • Process method for catalytic synthesis of poly lactic acid-glycolic acid by using bionic organic guanidinium
  • Process method for catalytic synthesis of poly lactic acid-glycolic acid by using bionic organic guanidinium

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Embodiment 1

[0025] Embodiment 1 - the synthesis of oligomeric lactic acid-glycolic acid

[0026] Put 45g of industrial-grade lactic acid aqueous solution LA with a mass content of 85% and 34g of glycolic acid GA with a mass content of 95% in the reaction kettle, repeat vacuuming-after three times of argon filling, heat under argon atmosphere and normal pressure To 130°C, dehydration reaction for 3 hours. Then the reactor was depressurized to 100 Torr and reacted at 130° C. for 3 hours. Finally, the reactor was depressurized to 30 Torr and reacted at 130° C. for 3 hours to obtain oligomeric lactic acid-glycolic acid OLGA with a yield of 98.6% and a weight average molecular weight of 220.

Embodiment 2

[0027] Embodiment 2 - the synthesis of oligomeric lactic acid-glycolic acid

[0028] Put 45g of industrial-grade lactic acid aqueous solution LA with a mass content of 85%, and 44.1g of glycolic acid GA with a mass content of 95% in the reactor, and repeat vacuuming—after three times of argon filling, heat under argon atmosphere and normal pressure To 160°C, dehydration reaction for 1 hour. Then the reactor was depressurized to 100 Torr and reacted at 160° C. for 1 hour. Finally, the reactor was decompressed to 30 Torr and reacted at 160° C. for 1 hour to obtain oligomeric lactic acid-glycolic acid OLGA with a yield of 98.2% and a weight average molecular weight of 320.

Embodiment 3

[0029] Embodiment 3 - the synthesis of oligomeric lactic acid-glycolic acid

[0030] Put 45g of industrial-grade lactic acid aqueous solution LA with a mass content of 85% and 14.6g of glycolic acid GA with a mass content of 95% in the reaction kettle and repeat vacuuming—after three times of argon filling, heat under argon atmosphere and normal pressure To 145°C, dehydration reaction for 2 hours. Then the reactor was depressurized to 100 Torr and reacted at 145° C. for 2 hours. Finally, the reactor was decompressed to 30 Torr and reacted at 145° C. for 2 hours to obtain oligomeric lactic acid-glycolic acid OLGA with a yield of 98.4% and a weight average molecular weight of 390.

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Abstract

The invention relates to a new method for synthesis of a medical biodegradable material poly lactic acid-glycolic acid by copolycondensation of lactic acid and glycolic acid through a catalysis effect of a bionic creatinine hydrochloride creatininium chloride (creatininium hydrochloride). According to the method, the bionic creatininium chloride is adopted as a catalyst, the industrial-grade lactic acid (LA, 85% aqueous solution) and the glycolic acid (GA, 95%) are adopted as monomers, and bulk solvent-free two-stage copolycondensation is performed to obtain the medical degradable poly lactic acid-glycolic acid with characteristics of high biological safety, no toxicity and no metal. According to the present invention, the method of the present invention has characteristics of green catalyst and solvent-free bulk polymerization; the catalyst creatininium chloride has high biocompatibility and high biological safety, and does not have cell toxicity; the synthesized poly lactic acid-glycolic acid does not contain any metals and other toxic residues, and is applicable for medical and medicinal materials; the process is simple and easy to operate, the raw material cost is low, the operation is simple, and the method is applicable for the industrial implementation.

Description

technical field [0001] The invention belongs to the technical field of medical biodegradable materials, and relates to the synthesis of high biosafety medical biodegradable polylactic acid-ethanol by using bionic organic guanidine salt—creatinine guanidine chloride as a catalyst, and taking lactic acid and glycolic acid as raw materials through co-condensation reaction sour method. Background technique [0002] Polylactic acid-glycolic acid PLGA has become an important medical biodegradable material because its degradation rate, mechanical properties and strength can be adjusted by changing the composition and molecular weight of the copolymer, and it has good biocompatibility and bioabsorbability. and biodegradability. Polylactic acid-glycolic acid has been widely used in many aspects of the biomedical field: such as implantable hard tissue repair materials, surgical sutures, targeting and controlled release drug carriers. The general synthesis of PLGA mainly adopts stann...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/06C08G63/87A61L27/18A61L27/58A61L27/50A61L17/12A61K47/34
Inventor 李弘张全兴江伟黄伟潘丙才
Owner NANJING UNIV
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