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Method for extracting Olibanum and Myrrha in Fengtongling medicament

An extraction method and Fengtongling technology are applied in the field of extraction of frankincense and myrrh, which can solve the problems of clinical use, physical injury, hidden safety hazards, etc.

Inactive Publication Date: 2012-07-04
ZHEJIANG JINGYUETANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under light, chloroform can also be oxidized by oxygen in the air into hydrogen chloride and highly toxic phosgene. Therefore, the use of chloroform as the extraction solvent in this production process may affect the production operators during the production process. cause bodily harm, and there may also be potential safety hazards in clinical use

Method used

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  • Method for extracting Olibanum and Myrrha in Fengtongling medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Frankincense 25g Myrrh 25g Blood Dragon 2g Thymol 10g

[0014] Borneol 30g Camphor 30g Menthol 280g Dichloromethane 27g

[0015] Essence 80ml Clove Basil Oil 40.1ml Methyl Salicylate Appropriate amount

[0016] For the above eleven flavors, take frankincense and myrrh and grind them into fine powder, take myrrh powder and add an appropriate amount of methyl salicylate, stir for 1 hour, let stand overnight, then add frankincense fine powder, stir at 38°C for 3 hours, filter, The filtrate is used for later use. Add dichloromethane to the dregs, stir for 0.5 hours, filter, and use the filtrate for later use. Dregs plus an appropriate amount of methyl salicylate, extract twice at 38°C, stir for 3 hours for the first time, 2 hours for the second time, filter, combine the above filtrates, add dried blood and other seven flavors, stir, dissolve, and filter , add methyl salicylate to 1000g, that is.

Embodiment 2

[0018] Frankincense 25g Myrrh 25g Blood Dragon 2g Thymol 10g

[0019] Borneol 30g Camphor 30g Menthol 280g Dichloromethane 50g

[0020] Essence 80ml Clove basil oil 40.1ml Methyl salicylate

[0021] For the above eleven flavors, take frankincense and myrrh and grind them into fine powder, take myrrh powder and add an appropriate amount of methyl salicylate, stir for 1 hour, let stand overnight, then add frankincense fine powder, stir at 38°C for 3 hours, filter, The filtrate is used for later use. Add dichloromethane to the dregs, sonicate for 0.5 hours, filter, and the filtrate (dichloromethane extract of frankincense and myrrh) is set aside. Dregs plus an appropriate amount of methyl salicylate, extract twice at 38°C, stir for 3 hours for the first time, 2 hours for the second time, filter, combine the above filtrates, add dried blood and other seven flavors, stir, dissolve, and filter , add methyl salicylate to 1000g, that is.

Embodiment 3

[0023] Frankincense 25g Myrrh 25g Blood Dragon 2g Thymol 10g

[0024] Borneol 30g Camphor 30g Menthol 280g Dichloromethane 100g

[0025] Essence 80ml Clove basil oil 40.1ml Methyl salicylate

[0026] For the above eleven flavors, take frankincense and myrrh and grind them into fine powder, take myrrh powder and add an appropriate amount of methyl salicylate, stir for 1 hour, let stand overnight, then add frankincense fine powder, stir at 38°C for 3 hours, filter, The filtrate is used for later use. Add dichloromethane to the dregs, reflux for 0.5 hours, filter, and use the filtrate for later use. Dregs plus an appropriate amount of methyl salicylate, extract twice at 38°C, stir for 3 hours for the first time, 2 hours for the second time, filter, combine the above filtrates, add dried blood and other seven flavors, stir, dissolve, and filter , add methyl salicylate to 1000g, that is. 2, the dichloromethane extract of embodiment 1 frankincense, myrrh and the comparative stud...

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Abstract

The invention relates to a method for extracting Olibanum and Myrrha in Fengtongling medicament, which replaces the methods for extracting Olibanum and Myrrha in Fengtongling medicament in the prior art. The invention is characterized in that methylene chloride is used as an extraction solvent during the extraction process; the consumption of methylene chloride is 0.1 to 2 times the total weight of Olibanum and Myrrha; the extraction method is one available in solvent extraction methods of traditional Chinese medicines and comprises the steps of mixing, ultrasonic treatment and refluxing; during the preparation process of Fengtongling medicament, the procedure of extracting Olibanum and Myrrha with methylene chloride is performed after first-time extraction with methyl salicylate or after second-time or third-time extraction with methyl salicylate; and the application of methylene chloride as extraction solvent of Olibanum and Myrrha in Fengtongling medicament can improve safety of production and application of Fengtongling medicament.

Description

technical field [0001] The invention relates to an extraction method of frankincense and myrrh, which is used to replace the extraction method of frankincense and myrrh in the current Fengtongling production process. Background technique [0002] Fengtongling (WS 3 -B-1709-94) product quality standard, its prescription composition is frankincense, myrrh, dried blood, thymol, borneol, camphor, menthol, clove basil oil, methyl salicylate. Function cures mainly: blood circulation promoting and blood stasis dispelling, detumescence and pain relieving, used for sprain and contusion pain, rheumatic arthralgia, chilblain redness and swelling. Among them, frankincense is the resin exuded from the bark of Boswellia carterii Birdw. and Boswellia bhaw-dajiana Birdw. of the same genus. Warm in nature and bitter in taste, the main components are free α-boswellic acid, β-boswellic acid, combined boswellic acid, ferulic acid, bitter quality, volatile oil, etc. Myrrh is the dry resin of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/328A61K36/324A61K36/889A61P29/00
Inventor 钱木水叶兴法韩鹏田利洪
Owner ZHEJIANG JINGYUETANG PHARMA
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