The invention relates to a preparation method of a multi-resin composite material. The preparation method comprises the steps of 1, preparing an inorganic powder component according to parts by weight; 2, selecting an isocyanate liquid material and a first inorganic powder component to be mixed and pre-impregnated to serve as a material A; 3, selecting a polyether polyol and polyester polyol combined liquid material, bisphenol A unsaturated polyester resin, bisphenol A epoxy resin, styrene, a second inorganic powder component and a titanate coupling agent, mixing and pre-impregnating to serve as a material B; and 4, mixing the material A and the material B obtained in the step 2 and the step 3, dispersing at a high speed, injecting into a mold, closing the mold, standing, and demolding to obtain the product. According to the multi-resin composite material, the adding amount of the inorganic powder component is greatly increased on the basis of improving the flame retardant property, a brand new and effective flame retardant system is constructed in a reaction system through the compounded inorganic powder component, and the preparation method is simple, so that the cost is greatly reduced, the pollution is reduced, and the application market of the multi-resin composite material is widened.