Production equipment and method for synthesizing 3-aminopropanol through continuous hydrogenation

An aminopropanol and production equipment technology, applied in the field of chemical organic synthesis, can solve the problems of solvent recovery, many side reactions, low production capacity, etc., and achieve the effects of reducing recovery costs, high flexibility in equipment operation, and low equipment cost

Pending Publication Date: 2020-11-27
BROTHER ENTERPRISES HLDG CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the reaction, a batch reactor is used to hydrogenate under high temperature and high pressure, which brings problems such as overheating, many side reactions, solvent recovery, and low production capacity.

Method used

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  • Production equipment and method for synthesizing 3-aminopropanol through continuous hydrogenation
  • Production equipment and method for synthesizing 3-aminopropanol through continuous hydrogenation

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specific Embodiment approach 2

[0037] Another core of the present invention is to provide a kind of method of continuous hydrogenation synthesis 3-amino propanol, claim it as specific embodiment two, and this method comprises the following steps:

[0038] ① Load the loaded nickel-based catalyst into the packed bed reactor and raise the temperature to a reaction temperature of 80-110°C;

[0039] ② After the membrane diffuses, the pressure gauge 8 reaches a certain pressure and the packed bed reaches a certain temperature, feed the three streams of 3-hydroxypropionitrile, hydrogen and ammonia into the membrane diffusion module and mix them thoroughly;

[0040] ③ The hydrogenation synthesis reaction of the reaction materials occurs in the packed bed reactor, and the pumping speed of 3-hydroxypropionitrile and the output pressure of hydrogen and amino groups are continuously maintained;

[0041] ④The reaction liquid obtained after the reaction in the packed bed reactor is separated into a gas phase (ammonia) an...

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Abstract

The invention relates to a synthetic method of 3-aminopropanol, in particular to production equipment and method for synthesizing 3-aminopropanol through continuous hydrogenation, and belongs to the technical field of chemical organic synthesis. The equipment mainly comprises a membrane diffusion module, a packed bed reactor and a gas-liquid separation device which are connected in sequence; the top end of the gas-liquid separation device is connected with an ammonia gas absorption device; a bottom outlet of the gas-liquid separation device is connected with a liquid phase collection device, and the liquid phase collection device is connected with a rectifying tower pipeline; the membrane diffusion module is provided with a liquid phase inlet and a gas phase inlet; a 3-hydroxypropionitrilestorage tank is connected with the liquid phase inlet; and a hydrogen steel cylinder and an ammonia gas steel cylinder are connected with a gas phase inlet through branch pipelines respectively. Themethod and the device disclosed by the invention are low in cost, high in total yield, good in safety and environment-friendly. In the absence of a solvent, a supported nickel-based catalyst and ammonia gas are used as co-catalysts, and hydrogen is introduced to reduce cyano groups, so that the defects of temperature runaway and low productivity of a kettle type reaction device are avoided, and the process route is economic, safe, green and environment-friendly,.

Description

technical field [0001] The invention relates to a synthesis method of 3-aminopropanol, in particular to a production equipment and method for continuous hydrogenation synthesis of 3-aminopropanol, belonging to the technical field of chemical organic synthesis. Background technique [0002] 3-Aminopropanol is a commonly used pharmaceutical intermediate, mainly used in the production of pharmaceuticals, pesticides and surfactants, and in the pharmaceutical field for the synthesis of cyclophosphonamides, propetin, pantothenic acid, panthenol, etc. Panthenol is not only useful in the treatment of skin diseases, burns and infected ulcers, but also is a valuable additive in shampoos and other cosmetics. [0003] Common methods for preparing 3-aminopropanol include acrylonitrile hydration to prepare 3-hydroxypropionitrile (US2579580, US3024267); 2-chloroethanol reacts with cyanide (US2311636) to prepare 3-hydroxypropionitrile; acrylonitrile reacts with ketoxime, Finally, hydrogena...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D3/00C07C213/02C07C213/10C07C215/08
CPCB01D3/009C07C213/02C07C213/10C07C215/08
Inventor 潘炎烽周中平
Owner BROTHER ENTERPRISES HLDG CO LTD
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