Hydrogel and preparation method thereof

A hydrogel and gel-forming technology, applied in the biomedical field, can solve the problem of uneven cross-linking of products, and achieve the effect of increasing self-confidence and even employment opportunities

Active Publication Date: 2012-07-04
孙珊 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to avoid a series of cumbersome processes such as reaction, cleaning, screening, mixing, and disinfection required for the preparation of microparticles, as well as the problem of uneven crosslinking caused by uneven mixing caused by injecting reagents separately, the present invention provides a Cross-linked injection-integrated hydrogel and preparation method thereof to simplify preparation process and reduce cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for preparing a hydrogel, comprising the following steps: first dissolving sodium alginate in a buffer solution, preparing a gel solution, putting it in a syringe, and putting a cross-linking agent of divalent calcium salt in another syringe, And the two syringes are linked together; then the two syringes are pushed back and forth for 3 seconds, so that the glue solution and the cross-linking agent are mixed evenly, and then injected, and the cross-linking reaction is completed after injection, from injection to The time to complete the cross-linking reaction was 3 minutes to obtain the hydrogel.

[0031] The mass volume ratio of the sodium alginate to the buffer solution is 1:100.

[0032] The hydrogel is used as a dermal filler.

Embodiment 2

[0034] A method for preparing a hydrogel, comprising the following steps: dissolving sodium alginate in a buffer solution, preparing a gel solution, sterilizing at a temperature of 110° C. for 10 minutes, putting it in a syringe, adding barium salt After the cross-linking agent was sterilized at 110°C for 10 minutes, it was loaded into another syringe, and the two syringes were linked together; then the two syringes were pushed back and forth for 10 seconds, so that the glue The solution is uniformly mixed with the cross-linking agent, and then injected, and the cross-linking reaction is completed after injection, and the time from injection to completion of the cross-linking reaction is 5 minutes to obtain the hydrogel.

[0035] The mass volume ratio of the sodium alginate to the buffer solution is 5:100.

Embodiment 3

[0037] A method for preparing a hydrogel, comprising the following steps: first dissolving sodium alginate in a buffer solution, preparing a gel solution, disinfecting it at a temperature of 130°C for 20 minutes, putting it in a syringe, and dissolving the bivalent After the cross-linking agent of calcium salt was sterilized under the condition of 130° C. for 20 minutes, it was installed in another syringe, and the two syringes were linked together; then the two syringes were pushed back and forth for 7 seconds, so that The glue solution and the cross-linking agent were uniformly mixed, and then injected, and the cross-linking reaction was completed after the injection, and the time from injection to the completion of the cross-linking reaction was 4 minutes to obtain the hydrogel.

[0038] The mass volume ratio of the sodium alginate to the buffer solution is 1:100-5:100.

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Abstract

The invention relates to a hydrogel and a preparation method thereof as well as biomedical application of the hydrogel used for a subcutaneous filling agent or a medicament carrier or a cytoskeleton. The preparation method comprises the following steps: firstly, dissolving sodium alginate in a buffer solution so as to prepare a gelatin solution, putting the gluing solution into an injector, putting a crosslinking agent into the other injector, and connecting the two injectors together; then pushing the two injectors back and forth so that the gelatin solution is evenly mixed with the crosslinking agent, injecting, and carrying out a crosslinking reaction after injection, so as to obtain the hydrogel. In the method, crosslinking and injection are integrated without disinfection after reaction, thereby avoiding the influence of a disinfection process on performances of a product.

Description

technical field [0001] The invention relates to a hydrogel and a preparation method thereof, belonging to the field of biomedicine. Background technique [0002] Hydrogels based on natural biomaterials are widely used in subcutaneous filling materials, drug carriers and tissue engineering technology due to their good biocompatibility. In order to make the material exhibit a unique shape, or have a certain mechanical strength, or delay the degradation rate to prolong the service life, it is usually necessary to improve the raw material, such as cross-linking is a common method. However, if the cross-linking agent is not properly controlled, for example, too little cross-linking concentration can ensure the injection of the material, but due to the slow reaction, the injected glue solution cannot be kept within a fixed range; and too high cross-linking agent concentration will lead to reaction Too fast and the material will become one after cross-linking and lose injectabilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/04A61K9/00A61K47/36A61L27/52A61L27/20
CPCC08L5/04C08J3/24A61L2400/06A61L27/52A61L27/20C08J3/075C08B37/0084C08J2305/04
Inventor 孙珊孙元
Owner 孙珊
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