A kind of preparation method of medicine solid preparation and obtained medicine solid preparation

Abstract

The invention discloses a preparation method of a pharmaceutical solid preparation, which comprises the following steps: dissolving water-insoluble and / or water-insoluble acidic pharmaceutical active ingredients in an alkaline solution containing an alkalizing agent to prepare a drug-containing alkaline solution ; Afterwards, uniformly mix the auxiliary materials and the alkaline liquid containing the medicine, and carry out wet granulation. The invention also discloses the medicine solid preparation prepared by the above method. The preparation method of the present invention avoids the defects of serious pollution, large loss and serious safety hazards caused by mechanical pulverization, and achieves the effect of reducing the particle size of the active ingredient of water-insoluble and / or water-insoluble acidic drugs during the granulation process . The method is simple and easy to operate, has a high safety factor, and is easy to apply to industrial production. The solid preparation prepared by the method has excellent dissolution characteristics, stability and content uniformity.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of a pharmaceutical solid preparation and the obtained pharmaceutical solid preparation. Background technique [0002] In the field of pharmaceutical preparations, the particle size of pharmaceutical active ingredients is closely related to the preparation process and quality of solid preparations. The reduction of particle size is the key to improving the dissolution rate and content uniformity of pharmaceutical preparations. In the preparation process of specific pharmaceutical preparations, the particle size of the active pharmaceutical ingredients is usually selected according to the dissolution characteristics of the medicine and the permeability of the biomembrane. For example, if it is a drug with poor solubility and drug dissolution is the rate-limiting process of absorption, a smaller particle size can be selected to promote dru...

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to overcome the existing solid preparation method to select and control the particle size of the pharmaceutical active ingredient through mechanical pulverization, which will cause environmental pollution, serious safety hazards, large loss, and the resulting solid pharmaceutical preparation However, for water-insoluble or poorly water-soluble acidic drugs, it is easier to operate, less polluted, without the aforementioned safety hazards, and can ensure that the prepared solid preparation has excellent dissolution characteristics. The preparation method of the pharmaceutical solid preparation of stability and content uniformity and the obtained pharmaceutical solid preparation

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