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Application of tetramethylpyrazine to preparation of medicine for treating contrast-induced nephropathy

A technology of contrast agent nephropathy and ligustrazine, which is applied in the application field of traditional Chinese medicine monomer ligustrazine in the preparation of drugs for the treatment of contrast agent nephropathy, can solve the problems that have not been reported, and achieve good application prospects and good effects of prevention and treatment of CIN

Inactive Publication Date: 2012-07-11
SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

However, there is no report about the application of the traditional Chinese medicine monomer tetramethylpyrazine in the preparation of medicines for the treatment of contrast nephropathy.

Method used

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  • Application of tetramethylpyrazine to preparation of medicine for treating contrast-induced nephropathy
  • Application of tetramethylpyrazine to preparation of medicine for treating contrast-induced nephropathy
  • Application of tetramethylpyrazine to preparation of medicine for treating contrast-induced nephropathy

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Embodiment 1

[0017] 1. Materials and methods

[0018] 1. Animals and reagents: 32 male SD rats, weighing 200±20g, were provided by the Shanghai Experimental Animal Center of the Chinese Academy of Sciences. Indomethacin, L-NAME (L-NAME, ie N ω -Nitro-L-arginine methyl ester hydrochloride, the molecular formula is C 7 h 15 N 5 o 4 HCl, a non-selective inhibitor of NOS (nitric oxide synthase), TMP, and NAC (N-acetylcysteine) were purchased from Sigma, and the contrast agent Iohexol was purchased from General Electric Pharmaceutical (Shanghai) Company. The TUNEL kit was produced by Roche in the United States, and the Caspase3 polyclonal antibody was purchased from Cell Signaling.

[0019] 2. Establishment and grouping of animal models: randomly divided into 4 groups, 8 animals in each group: group A is the normal group, group B is the model group, group C is the NAC group, and group D is the TMP group. Among them, the three groups B-C-D were all prepared CIN models according to the lit...

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Abstract

The invention relates to application of tetramethylpyrazine (TMP) to the preparation of a medicine for treating nephropathy. The nephropathy is contrast-induced nephropathy (CIN). The invention has the advantages that: novel use of a Chinese medicine monomer, namely the TMP is provided; the experimental result proves that the TMP can effectively protect the renal functions of cervical intraepithelial neoplasia (CIN) model rats, and has a good effect of preventing and treating CIN; the mechanism research discovers that the TMP can antagonize the apoptosis of a contrast agent, namely iohexol-induced rat renal tubular epithelial cells by inhibiting Caspase3; and the invention provides a novel therapeutic medicine for the CIN, and the novel therapeutic medicine has a good application prospect.

Description

technical field [0001] The invention relates to the application of a traditional Chinese medicine monomer, in particular, the application of the traditional Chinese medicine monomer ligustrazine in the preparation of medicine for treating contrast medium nephropathy. Background technique [0002] Contrast-induced nephropathy (CIN) refers to kidney disease caused by the use of iodine contrast media (CM), mainly manifested as acute renal failure (ARF). In high-risk groups, such as chronic kidney disease, diabetes, hypertension, or the elderly over 70 years old, the incidence of CIN can reach up to 50%. Studies have shown that CIN is currently the third cause of hospital-acquired ARF, accounting for about 30% of patients Renal function can not be restored and become chronic renal failure (chronic renal failure, CRF). [0003] According to the guidelines for the prevention and treatment of CIN, the exact molecular mechanism of CIN has not been clarified, and there is still a la...

Claims

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Application Information

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IPC IPC(8): A61K31/4965A61P13/12
Inventor 龚学忠
Owner SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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