Vaginal sterilizing foaming agent and preparation method thereof

The technology of a foam agent and a bactericide is applied in the field of a vaginal bactericide that can generate foam and its preparation field, and can solve the problems of easily destroying vaginal flora, insignificant treatment effect, loss of drugs, etc. Improve the utilization rate and sterilization efficiency, and the effect of convenient use process

Active Publication Date: 2013-08-21
石家庄诺利达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Internal medicines include capsules, tablets, etc. External medicines are mainly built-in suppositories and tablets. Most suppositories and tablets are inconvenient to use, which can easily cause foreign body sensation and damage the vagina
This dosage form mostly contains antibiotics such as metronidazole. Excessive use will easily destroy the balance of vaginal flora and make the disease more likely to recur
And when using a suppository, the suppository melts and easily flows out of the vagina, causing drug loss, and the suppository has a process of softening and melting, so the drug cannot be completely released in a short period of time, the drug effect is slow, and the distribution is uneven, and the therapeutic effect is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Formula: fungicide V80 1g, palmitic acid 257g, coconut oil fatty acid 75g, coconut oil fatty acid diethanolamide 28g, lecithin 20g, glycerin 100g, triethanolamine 80g, menthol 1g, deionized water 438g.

[0022] Preparation:

[0023] A. Take palmitic acid and coconut oil fatty acid according to the formula, heat to 60-70°C under stirring, and melt to obtain mixed solution a;

[0024] B, the triethanolamine taken by formula quantity is added into deionized water, fully stirred to obtain the aqueous solution b of triethanolamine;

[0025] C. Mix and stir solutions a and b to carry out saponification reaction. During the stirring process, add coconut oil fatty acid diethanolamide, glycerin, lecithin, menthol and fungicide V80 according to the formula amount, and continue to stir to make it mix and disperse evenly to obtain a mixed solution c;

[0026] D. Add deionized water at room temperature to adjust the viscosity of the mixed solution c to 140~180cP, and distribute it...

Embodiment 2

[0028] Formula: Fungicide single- and double-chain compound quaternary ammonium salt 2g, palmitic acid 270g, coconut oil fatty acid 78g, coconut oil fatty acid diethanolamide 30g, lecithin 20g, glycerin 100g, triethanolamine 85g, menthol 1g, deionized water 414g .

[0029] The preparation method is the same as in Example 1.

Embodiment 3

[0031] Formula: fungicide V80 3g, palmitic acid 300g, coconut oil fatty acid 75g, coconut oil fatty acid diethanolamide 50g, lecithin 15g, glycerin 95g, triethanolamine 95g, menthol 1g, deionized water 480g.

[0032] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a vaginal sterilizing foaming agent and a preparation method thereof. The vaginal sterilizing foaming agent comprises the following substances in part by mass: 0.1 to 0.3 part of bacteriacide, 32.0 to 38.0 parts of fatty acid, 2.8 to 5.0 parts of coconut oil fatty acid diethanolamide, 1.5 to 2.5 parts of lecithin, 9.5 to 10.5 parts of glycerol, 7.0 to 9.5 parts of triethanolamine, 0.1 part of menthol and 30 to 50 parts of deionized water. The preparation method comprises the following steps: A, melting fatty acid; B, preparing aqueous solution of triethanolamine; and C, mixing the fatty acid and the aqueous solution of triethanolamine, performing saponification, adding the remaning substances according to the formula proportion, mixing uniformly, and subpackaging into bottles with special devices to prepare the finished products. The sterilizing foaming agent is convenient to use, has wide coating range in the vagina and quick response, and can cure gynecological vaginal inflammation quickly and completely.

Description

technical field [0001] The invention relates to a gynecological vaginal bactericide and a preparation method thereof, in particular to a vaginal bactericide capable of producing foam and a preparation method thereof. Background technique [0002] Vaginitis and cervicitis are common diseases in gynecological clinics. For normal healthy women, due to the characteristics of anatomy and biochemistry, the vagina has a natural defense function against the invasion of pathogens. When the natural defense function is destroyed, pathogens are easy to invade and cause vaginal inflammation. There are also some female friends who stopped the treatment after the symptoms improved after simple treatment, and recurrent attacks were caused because the pathogens were not completely eliminated. If gynecological inflammation is not treated thoroughly, it is easy to develop further, causing more serious consequences, and even endangering life. The main bacteria that cause these gynecological i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K31/53A61K31/14A61K47/44A61P15/00A61P31/02A61P31/10A61P31/12
Inventor 任双军樊凯凯
Owner 石家庄诺利达医疗器械有限公司
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