Application of salvianolic acid A in pharmacy

Abstract

The invention discloses application of salvianolic acid A in pharmacy, and relates to application of salvianolic acid A in terms of preparation of medicines for suppressing activation of renal fibroblasts and intercapillary cells, preparation of medicines for reducing renal fibrosis, preparation of medicines for improving urine protein, preparation of medicines for improving renal functions, preparation of medicines for relieving renal inflammation and collagen deposition and preparation of medicines for relieving related genes and protein of renal fibrosis indexes. A screening platform for activation of renal fibroblasts and intercapillary cells of mice induced by TGF (transforming growth factor)-beta 1 is designed, and experiments show that from 4.94X10-5g / ml to 4.94X10-5g / ml of salvianolic acid A can suppress activation of the renal fibroblasts and intercapillary cells of the mice induced by the TGF-beta 1. A vitro experiment of the salvianolic acid A functioning to the mice in a UUO (unilateral ureteral obstruction) model and a Platt model is further designed and shows that medium-dosage salvianolic acid A (10mg / kg / d) and high-dosage salvianolic acid A (17.1mg / kg / d) can reduce urine protein, renal functions and related genes and protein of renal fibrosis of the mice in the UUO model and the Platt model.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to the use of salvianolic acid A, in particular to the application of salvianolic acid A in pharmacy. Background technique [0002] Renal fibrosis, characterized by glomerulosclerosis and tubulointerstitial fibrosis, is the final outcome of many chronic kidney diseases. Essentially, renal fibrosis is a process characterized by excessive accumulation and deposition of extracellular matrix. Activation of matrix-producing cells is key to the development of renal fibrosis. Under physiological conditions, fibroblasts produce an appropriate amount of collagen matrix to fill the space between nephrons, blood vessels and the renal capsule. The volume of the kidney gradually increases with age, and fibroblasts mainly play a role in remodeling the renal interstitium. When injury and inflammatory factors persist, fibroblasts proliferate and produce excess extracellular matrix. Newl...

AI Technical Summary

Problems solved by technology

[0006] At present, the role of salvianolic acid A in inhibiting the activation of renal fibroblasts and mesangial cells, reducing urinary protein in UUO model and Platt model rats (24h urine protein quantification, α1-MG, NAG, β2-MG, TRF) , renal function (Scr, BUN), reducing renal inflammation and collagen deposition, and improving renal fibrosis-related genes and proteins (TGF-β1, CTGF, CollagenIII, LN, Collagen I, FN) have not yet been reported

Images