Dropping pill of isatis root and folium isatidis and preparing method thereof

A technology of green dripping pills and Radix isatidis, applied in the field of Banlan Daqing dripping pills and its preparation, which can solve the problems of insufficient dissolution of active ingredients, low bioavailability, slow release, etc.

Active Publication Date: 2013-06-12
HEILONGJIANG TIANYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Radix Isatidis and Folium Folium are classic medicinal materials for treating colds, but some active ingredients in the two medicinal materials are not easily soluble in water and ethanol. Traditional water extraction and alcohol extraction methods cannot fully dissolve the active ingredients, and the release of conventional dosage forms is slow. , low bioavailability, affecting curative effect

Method used

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  • Dropping pill of isatis root and folium isatidis and preparing method thereof
  • Dropping pill of isatis root and folium isatidis and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 1500g of Radix Isatidis, 2250g of Folium Isatidis, and crush it into a 40-mesh coarse powder, use carbon dioxide supercritical extraction method to extract, extraction pressure is 35Mpa, extraction temperature is 35°C, separator pressure is 20Mpa, separator temperature is 55°C, separation time is 2 hours, carbon dioxide flow rate 35L per hour to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; take the dry paste and add 3 times the amount of polyethylene glycol 4000 to mix, control the material temperature to 75°C, the condensation temperature to 6°C, and the drop distance to 4.0 ㎝, dripping at a rate of 40 drops per minute, drop into liquid paraffin, take out after the drop pills are formed, absorb the surface cooling liquid, and dry to obtain Banlan Daqing drop pills.

specific Embodiment 2

[0015] Take 1500g of Radix Isatidis, 2250g of Folium Isatidis, and crush it into a 40-mesh coarse powder, extract by supercritical carbon dioxide extraction, extraction pressure 25Mpa, extraction temperature 25°C, separator pressure 10Mpa, separator temperature 45°C, separation time 2 hours, carbon dioxide flow rate 25L per hour to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; take the dry paste and add 2 times the amount of polyethylene glycol 4000 to mix well, control the material temperature at 65°C, the condensation temperature at 4°C, and the drop distance of 2.0 ㎝, dripping at a rate of 20 drops per minute, drop into liquid paraffin, take out after the drop pills are formed, absorb the cooling liquid on the surface, and dry to obtain Banlan Daqing drop pills.

Embodiment 3

[0017] Take 1500g of Radix Isatidis, 2250g of Folium Isatidis, and crush it into a 40-mesh coarse powder, use carbon dioxide supercritical extraction method to extract, extraction pressure 30Mpa, extraction temperature 30°C, separator pressure 30Mpa, separator temperature 50°C, separation time 2 hours, carbon dioxide flow rate 30L per hour to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; take the dry paste and add 2.5 times the amount of polyethylene glycol 4000 to mix, control the material temperature to 70°C, the condensation temperature to 5°C, and the drop distance to 3.0 ㎝ at a rate of 30 drops per minute, drop into liquid paraffin, take out the drop pills after they are formed, absorb the cooling liquid on the surface, and dry to obtain Banlan Daqing drop pills.

[0018] The above examples illustrate that the extreme conditions and optimized conditions of the embodiments of the present invention can be used to make B...

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Abstract

The invention discloses a dropping pill of isatis root and folium isatidis and a preparing method thereof, wherein the preparing method is characterized in that: isatis root and folium isatidis are extracted in a carbon dioxide supercritical extraction method and dried under reduced pressure to generate dried paste, polyethylene glycol 4000 is added and evenly mixed, and liquid paraffin is dropped in so as to prepare the dropping pill of isatis root and folium isatidis. The dropping pill of isatis root and folium isatidis is used for treating grippe, the curative effect is obviously better than commercially-available drugs with the same kind, and better effect is obtained.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Banlan Daqing dripping pill and a preparation method thereof. Background technique [0002] Seasonal cold is an acute exogenous febrile disease with fever and chills, head and body pain, fatigue, nasal congestion, runny nose, sneezing, and coughing as the main clinical manifestations caused by seasonal evils. It is a frequently-occurring disease. Radix Isatidis and Folium Folium are classic medicinal materials for treating colds, but some active ingredients in the two medicinal materials are not easily soluble in water and ethanol. Traditional water extraction and alcohol extraction methods cannot fully dissolve the active ingredients, and the release of conventional dosage forms is slow. , low bioavailability, affecting efficacy. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides a Banlan Daqing dripp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/315A61P31/16
Inventor 孙长海张舒婷任恒鑫
Owner HEILONGJIANG TIANYI PHARMA
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