A kind of Xiaoer Qingyan granule and its preparation method

A granule, pediatric technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of active ingredient destruction, insufficiency, loss, etc. Effect

Active Publication Date: 2018-03-09
河北百善药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the extraction process is unreasonable and unscientific, it will inevitably cause damage and loss of active ingredients, thereby affecting the quality and curative effect of the preparation
[0004] With the continuous improvement of clinical requirements on the quality and effect of drugs and the continuous development of pharmaceutical technology, this technology can no longer meet the current needs. There is an urgent need for a preparation technology with more complete extraction of active ingredients and higher content to better play the role of children. The Medicinal Value of the Classical Prescription of Qingyan Granules

Method used

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  • A kind of Xiaoer Qingyan granule and its preparation method
  • A kind of Xiaoer Qingyan granule and its preparation method
  • A kind of Xiaoer Qingyan granule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074]

[0075] Take 1 / 3 of Radix Radix and 1 / 3 of Forsythia, wash and dry them separately, and use a high-speed pulverizer to crush them through an 80-mesh sieve to get fine powder; wash and dry Scrophulariaceae and cicada slough respectively, and crush them with high speed Machine crushed through 80-mesh sieve to get fine powder; wash the remaining 2 / 3 of Radix isatidis, decoct twice with 8 times the amount of water, the first time for 2 hours, the second time for 1.5 hours, combine the two decoctions, Filter, concentrate the filtrate to 80°C to measure the relative density of 1.15-1.18, add ethanol to make the alcohol content reach 65%, let stand, take the supernatant to recover ethanol, and concentrate to 80°C to measure the relative density of 1.25-1.30. Cream A; wash the remaining 2 / 3 of the forsythia with water, add 8 times the amount of water to decoct twice, the first time for 2 hours, the second time for 1.5 hours, combine the two decoctions, filter, and centrifuge...

Embodiment 2

[0077]

[0078] Take 1 / 3 of Radix Radix and 1 / 3 of Forsythia, wash and dry them separately, and use a high-speed pulverizer to crush them through an 80-mesh sieve to get fine powder; wash and dry Scrophulariaceae and cicada slough respectively, and crush them with high speed Machine crushed through 80-mesh sieve to get fine powder; wash the remaining 2 / 3 of Radix isatidis, decoct twice with 8 times the amount of water, the first time for 2 hours, the second time for 1.5 hours, combine the two decoctions, Filter, concentrate the filtrate to 80°C to measure the relative density of 1.15-1.18, add ethanol to make the alcohol content reach 65%, let stand, take the supernatant to recover ethanol, and concentrate to 80°C to measure the relative density of 1.25-1.30. Cream A; wash the remaining 2 / 3 of the forsythia with water, add 8 times the amount of water to decoct twice, the first time for 2 hours, the second time for 1.5 hours, combine the two decoctions, filter, and centrifuge...

Embodiment 3

[0080]

[0081] Take 1 / 3 of Radix Radix and 1 / 3 of Forsythia, wash and dry them separately, and use a high-speed pulverizer to crush them through an 80-mesh sieve to get fine powder; wash and dry Scrophulariaceae and cicada slough respectively, and crush them with high speed Machine crushed through 80-mesh sieve to get fine powder; wash the remaining 2 / 3 of Radix isatidis, decoct twice with 8 times the amount of water, the first time for 2 hours, the second time for 1.5 hours, combine the two decoctions, Filter, concentrate the filtrate to 80°C to measure the relative density of 1.15-1.18, add ethanol to make the alcohol content reach 65%, let stand, take the supernatant to recover ethanol, and concentrate to 80°C to measure the relative density of 1.25-1.30. Cream A; wash the remaining 2 / 3 of the forsythia with water, add 8 times the amount of water to decoct twice, the first time for 2 hours, the second time for 1.5 hours, combine the two decoctions, filter, and centrifuge...

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Abstract

The invention discloses Xiao'er Qingyan granule. The preparation method of the granules is as follows: take 1 / 3 of Radix Radix and Forsythia pulverized into fine powder; Scrophulariaceae and cicada slough into fine powder; the remaining 2 / 3 of Radix Radix is ​​decocted with water to decoct with alcohol to make clear cream A; and the remaining 2 / 3 Forsythia fruticosa was decocted with water and separated to obtain extract B; burdock fruit and peppermint were placed to extract volatile oil C; burdock fruit and mint dregs were decocted and filtered to obtain filtrate D; Burdock fruit and peppermint filtrate D are combined and concentrated to obtain clear cream E; stir clear cream A, extract B, volatile oil C and clear cream E evenly, then add isatid root, forsythia, scrophulariaceae and cicada slough fine powder and mix evenly to get extract. Add sucrose and dextrin to granulate. The advantages of the present invention are that the improved process has more complete extraction of active ingredients, higher content, and better stability, and the addition of auxiliary materials in the improved preparation process is greatly reduced compared with the original pharmacopoeia process, and at the same time, it can also reduce patients. Dosage.

Description

technical field [0001] The invention relates to a pharmaceutical preparation in the field of medicine, in particular to a Xiaoer Qingyan granule and a preparation method thereof. Background technique [0002] Xiaoer Qingyan Granules are listed in the Chinese Pharmacopoeia. It is prepared from Scrophulariae Scrophulariae, Dandelion, Burdock Seed, Peppermint, Cicada Slough, Radix Isatidis, Forsythia, Moutan Bark and Indigo Daisy. It is used for fever, headache, hoarse cough, and sore throat in children caused by exogenous wind-heat. [0003] At present, the preparation process of Xiaoer Qingyan Granules basically follows the traditional decoction method, extracting volatile oil from mint, and decocting other raw materials together. Due to mixed extraction or decoction, the active ingredients of the single raw materials will be unstable, and the extraction rate of the active ingredients will be greatly reduced by mixed decoction of the raw materials, and a large amount of wat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/808A61P11/04A61P29/00A61P11/14A61K35/64
Inventor 韩志强
Owner 河北百善药业有限公司
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