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A kind of anti-inflammatory tablet and preparation method thereof

A technology for anti-inflammatory tablets and filtrate, applied in the field of anti-inflammatory tablets and their preparation, can solve problems such as unreasonable extraction process, influence on drug absorption, destruction of effective components, etc., and achieve the effects of avoiding adverse effects, reducing production costs, and completing extraction.

Active Publication Date: 2019-11-29
韩志强 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the extraction process is unreasonable and unscientific, it will inevitably cause damage and loss of active ingredients, thereby affecting the quality and curative effect of the preparation
In addition, the disintegration time of the existing anti-inflammatory tablets is relatively long, especially after long-term storage, there is a phenomenon that exceeds the pharmacopoeia standard. Too long disintegration time will seriously affect the absorption of drugs
[0004] With the continuous improvement of clinical requirements for drug quality and effect and the continuous development of pharmaceutical technology, this technology can no longer meet the current needs. There is an urgent need for a preparation technology with more complete extraction of active ingredients and higher content to better play anti-inflammatory Medicinal Value of the Classical Prescription of Tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Dandelion 446g Viola 446g Wild chrysanthemum 446g

[0090] Scutellaria baicalensis 446g;

[0091] Take 1 / 2 amount of Scutellaria baicalensis, wash and dry it, and use a high-speed pulverizer to crush it through an 80-mesh sieve to obtain a fine powder; take 1 / 3 amount of dandelion and 1 / 3 amount of wild chrysanthemum, wash and dry it separately, Pulverize with a pulverizer and pass through an 80-mesh sieve to obtain a fine powder; wash the remaining 1 / 2 amount of Scutellaria baicalensis, soak it in 16 times the amount of water for 30 minutes, add 9 parts by weight of a compound enzyme, and carry out enzymolysis at 40°C for 30 minutes, and then Decocting, decocting for the first time for 3 hours, filtering to obtain the filtrate, decocting the dregs with 14 times the amount of water for 2 hours, filtering to obtain the filtrate, combining the two filtrates, filtering, and concentrating the filtrate to 80 ° C to measure the relative The density is 1.15-1.18, add ethanol ...

Embodiment 2

[0093] Dandelion 230g Viola 660g

[0094] Wild chrysanthemum 230g, scutellaria baicalensis 660g.

[0095] Take 1 / 2 amount of Scutellaria baicalensis, wash and dry it, and use a high-speed pulverizer to crush it through an 80-mesh sieve to obtain a fine powder; take 1 / 3 amount of dandelion and 1 / 3 amount of wild chrysanthemum, wash and dry it separately, Pulverize and pass through an 80-mesh sieve to obtain fine powder; wash the remaining 1 / 2 amount of Scutellaria baicalensis, soak it in 16 times the amount of water for 30 minutes, add 9 parts by weight of compound enzyme, and carry out enzymolysis at 40°C for 30 minutes. Then decoct, decoct for the first time for 3 hours, filter to obtain the filtrate, and decoct the dregs with 14 times the amount of water for 2 hours, filter to obtain the filtrate, combine the two filtrates, filter, and concentrate the filtrate to 80 ° C. The relative density is 1.15-1.18, add ethanol to make the alcohol content reach 65%, let it stand still...

Embodiment 3

[0097] Dandelion 660kg Viola 230kg

[0098] Wild chrysanthemum 660kg, Scutellaria baicalensis 230kg.

[0099] Take 1 / 2 amount of Scutellaria baicalensis, wash and dry it, and use a high-speed pulverizer to crush it through an 80-mesh sieve to obtain a fine powder; take 1 / 3 amount of dandelion and 1 / 3 amount of wild chrysanthemum, wash and dry it separately, Pulverize with a pulverizer and pass through an 80-mesh sieve to obtain a fine powder; wash the remaining 1 / 2 amount of Scutellaria baicalensis, soak it in 16 times the amount of water for 30 minutes, add 9 parts by weight of a compound enzyme, and carry out enzymolysis at 40°C for 30 minutes, and then Decocting together, decocting for the first time for 3 hours, filtering to obtain the filtrate, decocting the dregs with 14 times the amount of water for 2 hours, filtering to obtain the filtrate, combining the two filtrates, filtering, concentrating the filtrate to 80°C and measuring The relative density is 1.15-1.18, add e...

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PUM

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Abstract

The invention discloses an anti-inflammatory tablet. The anti-inflammatory tablet comprises dandelion, purpleflower violet, wild chrysanthemum flowers and baical skullcap roots. A preparation method includes grinding 1 / 2 of the baical skullcap roots into fine powder; grinding 1 / 3 of the dandelion and 1 / 3 of the wild chrysanthemum flowers into fine powder; adding compound enzyme into remaining 1 / 2 of the baical skullcap roots for enzymolysis and decocting to obtain clear paste A; subjecting remaining 2 / 3 of the dandelion to enzymolysis by compound enzyme and decocting to obtain extract B; obtaining volatile oil C from the purpleflower violet; decocting purpleflower violet decoction dregs with water to obtain filtrate D; decocting remaining 2 / 3 of the wild chrysanthemum flowers with water and blending the obtained wild chrysanthemum flower decoction with the filtrate D to obtain clear paste E; stirring the clear paste A, the extract B, the volatile oil C and the clear paste E uniformly, adding the fine powder of the baical skullcap roots, the dandelion and the wild chrysanthemum flowers for mixing uniformly, adding crospovidone and croscarmellose sodium for mixing uniformly and tabletting. The anti-inflammatory tablet is more complete in technological extraction, higher in content and stability and shorter in disintegration time, and adverse effect of disintegration slowness on treatment effect is avoided.

Description

technical field [0001] The invention relates to a pharmaceutical preparation in the medical field, in particular to an anti-inflammatory tablet and a preparation method thereof. Background technique [0002] Xiaoyan Tablets are listed in the Chinese Pharmacopoeia. It is prepared from dandelion, viola, wild chrysanthemum and skullcap, which has antibacterial and anti-inflammatory properties. It is used to treat respiratory infection, fever, pneumonia, bronchitis, cough with phlegm or boils, etc. [0003] At present, the preparation process of Xiaoyan Tablets basically follows the method of traditional decoction, crushing Scutellaria baicalensis into fine powder, and decocting other three-flavored raw materials together. Due to mixed extraction or decoction, the active ingredients of the single raw materials will be unstable, and the extraction rate of the active ingredients will be greatly reduced by mixed decoction of the raw materials, and a large amount of water-soluble ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/86A61K9/20A61K47/38A61K47/32A61P11/00A61P29/00
Inventor 韩志强
Owner 韩志强
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