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Compound Shiwei dispersible tablet and preparation method thereof

A technology of compound shiwei and dispersible tablets, which is applied in the field of compound shiwei dispersible tablets and its preparation, and can solve problems such as inability to dissolve active ingredients, difficult extraction of chlorogenic acid, and influence on curative effect

Active Publication Date: 2016-06-29
HEILONGJIANG TIANYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its active ingredient chlorogenic acid is not easy to extract, and the traditional extraction method cannot fully dissolve the active ingredient. At the same time, the disintegration of ordinary preparations is slow and the bioavailability is low, which seriously affects the curative effect.

Method used

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  • Compound Shiwei dispersible tablet and preparation method thereof
  • Compound Shiwei dispersible tablet and preparation method thereof
  • Compound Shiwei dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 740g of Shiwei, 740g of Astragalus, 740g of Sophora flavescens, and 740g of flat storage, add 10 times the amount of water, soak for 1 hour, add 30g of sodium carbonate, reflux for 4 hours, filter, and concentrate the filtrate to a relative density of 1.15 (50°C). For clear ointment, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, concentrate the supernatant to a clear ointment with a relative density of 1.05-1.15 (50°C), spray dry, add 20g of silicon dioxide, and place in a high-energy nano-shock Grind into a mixed dry cream powder with a particle size of 150-250nm in the mill; add 5g of calcium sulfate, 10g of sodium chloride, 10g of cross-linked polyvinylpyrrolidone, 4g of sodium carboxymethyl starch, 10g of microcrystalline cellulose, 5g of lactose, and dextrin 5g, maltose 2g, mixed evenly, wet granulated with 50% ethanol, dried at 60°C, added 1g of talcum powder, granulated, compressed into tablets to make compound Shiwei dispersib...

specific Embodiment 2

[0028] Take 740g of Shiwei, 740g of Astragalus, 740g of Sophora flavescens, and 740g of flat storage, add 10 times the amount of water, soak for 1 hour, add 30g of sodium carbonate, reflux for 4 hours, filter, and concentrate the filtrate to a relative density of 1.15 (50°C). For clear ointment, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, concentrate the supernatant to a clear ointment with a relative density of 1.05-1.15 (50°C), spray dry, add 20g of silicon dioxide, and place in a high-energy nano-shock Grind into a mixed dry cream powder with a particle size of 150-250nm; add 15g of calcium sulfate, 20g of sodium chloride, 15g of cross-linked polyvinylpyrrolidone, 6g of sodium carboxymethyl starch, 20g of microcrystalline cellulose, 15g of lactose, and dextrin 15g, 4g of maltose, mixed evenly, wet granulated with 50% ethanol, dried at 80°C, added 3g of talcum powder, granulated, compressed into tablets to make compound Shiwei dispersible tab...

Embodiment 3

[0030] Take 740g of Shiwei, 740g of Astragalus, 740g of Sophora flavescens, and 740g of flat storage, add 10 times the amount of water, soak for 1 hour, add 30g of sodium carbonate, reflux for 4 hours, filter, and concentrate the filtrate to a relative density of 1.15 (50°C). For clear ointment, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, concentrate the supernatant to a clear ointment with a relative density of 1.05-1.15 (50°C), spray dry, add 20g of silicon dioxide, and place in a high-energy nano-shock Grind into a mixed dry cream powder with a particle size of 150-250nm in the mill; add 10g of calcium sulfate, 15g of sodium chloride, 12g of cross-linked polyvinylpyrrolidone, 5g of sodium carboxymethyl starch, 15g of microcrystalline cellulose, 10g of lactose, and dextrin 10g, 3g of maltose, mixed evenly, wet granulated with 50% ethanol, dried at 70°C, added 2g of talcum powder, granulated, compressed into tablets to make compound Shiwei dis...

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Abstract

The invention discloses a compound Shiwei dispersible tablet and a preparation method thereof. Ointment, plus functional auxiliary materials to prepare solid dispersion preparations, used to treat nephritis, cystitis, urethritis, its active ingredient content, disintegration performance, and curative effect are significantly better than commercially available drugs, and good results have been achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a compound Shiwei dispersible tablet and a preparation method thereof. Background technique [0002] The compound Shiwei group is composed of Shiwei, Astragalus, Sophora flavescens, and Bianzhu four traditional Chinese medicines. It has the effects of clearing away heat and dampness, diuresis and treating stranguria. It is used to treat dysuria, frequent urination, urgency, painful urination, and lower limb edema ; It can also be used for acute and chronic glomerulonephritis, pyelonephritis, cystitis, urethritis, see those who have the above symptoms. However, its active ingredient chlorogenic acid is not easy to extract, and the traditional extraction method cannot fully dissolve the active ingredient. At the same time, the disintegration of ordinary preparations is slow and the bioavailability is low, which seriously affects the curative effect. Contents of the in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A61K9/20A61P13/00A61P13/12A61P13/10A61P13/02
Inventor 赵燕翼
Owner HEILONGJIANG TIANYI PHARMA
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