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Valve prosthesis

A valve prosthesis and prosthesis technology, applied in prosthesis, heart valve, medical science, etc.

Active Publication Date: 2012-09-12
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Of the publicly available designs, no transdermal valve stents currently exist with the characteristics considered desirable for successful implantation, stability, and long-term operation

Method used

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  • Valve prosthesis
  • Valve prosthesis
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0031] The following disclosure relates to a first general embodiment of the present disclosure, which relates to the valve prosthesis of the present invention and a method for replacing a damaged or diseased valve.

[0032] In one aspect, a valve prosthesis is provided, which includes: a self-expanding stent including an outer surface, an inner surface, a middle region, an upper anchoring flange, and a lower anchoring flange, wherein the stent has an unexpanded state and Expanded state; a cuff, the cuff includes an absorbent material disposed at least partially circumferentially around the outer surface of the stent, wherein the absorbent material expands by absorbing fluid to make the prosthesis substantially attached to the implantation site, and wherein the anchoring is The delay is sufficient time to allow the prosthesis to be positioned at the implantation site; and a valve that includes at least two leaflets fixedly attached to the inner surface of the stent. In a preferre...

Embodiment II

[0055] The following description relates to the second general embodiment of the present disclosure, which relates to the valve prosthesis of the present invention; a method for replacing a damaged or diseased valve; a system for delivering a valve prosthesis; a kit; and for delivery Valve prosthesis method.

[0056] In one aspect, a valve prosthesis is provided, which includes: an at least partially self-expanding stent, the stent including a wire skeleton defining an outer surface and an inner surface, and upper and lower anchoring flanges inserted into the middle region, the stent having a An expanded state and an expanded state, and the lower anchoring flange has at least one geometric size larger than the corresponding size of the upper anchoring flange; and a valve including at least one leaflet fixedly attached to the inner surface of the stent.

[0057] The stent may be configured to be at least partially self-expanding. For example, the stent may be capable of self-expand...

example 1

[0116] Example 1-Percutaneous implantation via transfemoral method

[0117] Using the system for delivering valve prostheses disclosed in the present invention and the valve prostheses according to the present disclosure, exemplary delivery and implantation procedures can be performed as follows.

[0118] First, enter the femoral vein (right or left) and use the Seldinger technique to insert the vascular sheath. A standard transseptal technique is used to traverse the atrial septum, and a balloon dilatation atrial septostomy (10-15mm angioplasty balloon) creates / enlarges the atrial hole.

[0119] The super-hard guide wire is carefully shaped and then positioned in the left ventricle through the newly created atrial hole. The femoral vein entry site is made larger or "dilated up" using a continuously enlarged vasodilator, where the vasodilator is appropriately sized to match the diameter of the delivery system.

[0120] The valve prosthesis is compressed and positioned on the docking ...

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Abstract

The present disclosure relates to valve replacement devices that are foldable for catheter- based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporates an appropriate leaflet system for reliable functioning in situ.

Description

[0001] Cross references to related applications [0002] This application claims priority to U.S. Provisional Application No. 61 / 241,659 filed on November 5, 2009, which is incorporated herein by reference in its entirety. Technical field [0003] The present disclosure relates to anatomical valve replacement devices and methods and systems for replacing valves and for delivering stented devices. Background technique [0004] The mitral valve is a complex structure whose capabilities depend on the precise interaction of annulus, leaflets, chordae, papillary muscles, and left ventricle (LV). Pathological changes in any of these structures can cause valve insufficiency. Mucinous lobule / chordine degeneration and dilated ischemic cardiomyopathy secondary to ventricular remodeling after chronic myocardial infarction are the two most common mitral regurgitation (MR) pathogenesis. These two disease processes account for approximately 78% of all surgically treated MR cases. [0005] As par...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/24
CPCA61F2/2436A61F2210/0061A61F2220/0008A61F2250/0039A61F2250/0069A61F2230/0054A61F2230/0058A61F2230/0078A61F2/2418A61F2/24A61F2/2409A61F2210/0076A61F2250/003A61F2210/0004A61F2210/0014
Inventor 约瑟夫·H·戈尔曼三世罗伯特·C·戈尔曼马修·J·吉莱斯皮
Owner THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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