61 results about "Perivalvular Leak" patented technology

The application provides a kind of replacement valve device and its support by catheterization, it is related to heart valve technical field.The replacement valve support by catheterization includes support main body, anchoring structure, skirt support structure and sealing membrane.The sealing membrane is circumferentially closed cylindrical structure, sealing membrane includes the first sealing section and the second sealing section being arranged along the axial direction and being connected with each other, the first sealing section is tightly arranged on part or all of skirt support structure, the second sealing section is tightly arranged on part or all of support main body;Sealing membrane is arranged on the inner side and / or outer side of skirt support structure and support main body.The application can solve the problem that sealing membrane and valve support do not fit in the prior art, poor sealing, leading to sealing membrane in blood, leading to paravalvular leakage or causing other complications, with high degree of fit, good sealing, can avoid sealing membrane in blood, effectively avoid paravalvular leakage or cause other complications.

The invention relates to the technical field of medical instruments, and provides a valve prosthesis and a preparation method thereof.The valve prosthesis comprises a valve frame and a flexible leakage-proof part arranged on the valve frame; the direction, where blood can flow, of the valve prosthesis is defined as the vertical direction, the valve frame comprises a positioning part which can be positioned on the upper side of a human heart valve ring, and the flexible leakage-proof piece comprises a containing part which can be filled with blood and is located on the lower side of the positioning part after being filled with the blood. The containing part comprises an inward extending section extending inwards in the radial direction of the valve frame and an edge part located on the edge of the inward extending section, at least part of the edge part extends outwards in the radial direction of the valve frame to form an outward extending section, and the outward extending section is located on the upper side of the inward extending section. According to the technical scheme, the problem of perivalvular leakage is solved.

A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

The present invention provides a series of new percutaneous concepts of paravalvular repairs including identifying the leak location, several repair techniques and finally built-in means for leak prevention, built on percutaneous valves. A catheter-delivered device locates cavities occurring between a prosthetic valve (250) and the wall of the body vessel where the valve is implanted, the cavities producing paravalvular leaks during diastole, the device comprising at least one of a plurality of flexible wires, the wire having attached to it a balloon, wherein the balloon is pulled by the leak through the cavity and wherein the wire then serves to mark the cavity location.

This invention discloses a novel valve stent and artificial heart valve, belonging to the field of medical device technology. The valve stent has a hollow, symmetrical, mesh-like tubular structure, with a first layer of hexagonal mesh groups, a second layer of polygonal mesh groups, and a third layer of polygonal mesh groups arranged sequentially from the outflow end to the inflow end. The stent has a small overall mesh count and symmetrical structure, resulting in uniform deformation during compression and expansion. It exhibits excellent radial support and minimal expansion rebound, significantly reducing the risk of paravalvular leakage. While maintaining radial support, this invention can reduce the stent strut width to 0.2–0.4 mm, and the minimum outer diameter of the valve after compression can reach 2.5–4.5 mm. Simultaneously, the overall length change during stent compression and expansion is minimal, greatly improving the smoothness of vascular delivery and the accuracy of valve implantation positioning. This meets the clinical needs of transcatheter aortic valve replacement surgery, enhancing the safety and effectiveness of artificial heart valve implantation.

The invention discloses an integrated heart valve stent capable of preventing coronary artery opening blockage, and relates to the field of heart valve stent integrated heart valve stents. The integrated heart valve stent capable of preventing the coronary artery opening from being blocked comprises a main stent body and a plurality of sets of positioning pieces used for being inserted into the sinus floor of a heart valve. The main body support comprises multiple sets of full supporting pieces and multiple sets of semi-supporting pieces which are sequentially connected, and the multiple sets of full supporting pieces which are sequentially connected are arranged between the sets of semi-supporting pieces. Coronary artery passing holes and supporting holes are formed in each group of semi-supporting pieces. And the positioning piece is connected with the full supporting piece or the semi-supporting piece. By means of the arrangement, the coronary artery opening is prevented from being blocked while the supporting force of the main body support is guaranteed, a follow-up coronary artery repairing instrument can be allowed to enter from the coronary artery passing hole, and meanwhile the risk of perivalvular leakage is reduced.

A prosthetic heart valve includes a collapsible stent and a valve assembly disposed within the stent. A first cuff is disposed adjacent the stent. A second cuff having a distal edge facing the outflow end of the stent is disposed about the stent radially outward of the first cuff and the stent. The stent may include a plurality of fingers each having a first end coupled to a corresponding cell of the stent and a free end adapted to extend radially outward of the corresponding cell. The distal edge of the second cuff may be coupled to the fingers at spaced locations around the circumference of the stent to position the distal edge radially outward from the corresponding cells at the spaced locations. Various stent struts may be tapered to reduce the stent circumference in the collapsed condition, and to improve the fatigue resistance and / or bendability of the stent.

The utility model relates to the technical field of medical instruments, in particular to an artificial valve clamping piece and a conveying system. The artificial valve clamping piece comprises a clamping piece body, a connecting wire and a traction structure, the clamping piece body comprises a pipe body and a plurality of through holes formed in the pipe body, the pipe body is in a wave shape, and the two ends of the pipe body are closed to form a ring shape; the connecting wire penetrates into the tube body, and the end part of the connecting wire penetrates through the through hole in the tube body and then is suitable for being connected with the artificial valve; the traction structure comprises a traction wire, the traction wire is arranged in the pipe body in a penetrating mode through a through hole in the pipe body, and the traction wire is suitable for being connected with a conveying system. The clamping piece is of a periodic wave-shaped or fluctuating annular structure, can be fixed to the periphery of the outer surface of the artificial valve, can be radially compressed and expanded according to the size of the internal artificial valve, and is matched with the artificial valve to clamp the autologous valve leaflet, so that the artificial valve can be stably anchored at an accurate position without displacement, and meanwhile, the clamping piece can be used for clamping the autologous valve leaflet. The clamping device can reduce the occurrence risk of perivalvular leakage.

The present application relates to a kind of artificial heart valve stents and artificial heart valve.The artificial heart valve stent includes inner support and outer support.Inclination from inflow end to outflow end, first portion and second portion are included in sequence in inner support, the radial dimension of first portion is greater than the radial dimension of second portion, at least a portion of second portion is nested in outer support, and at least a portion of first portion extends to inflow end relative to outer support, and the portion of first portion extending to inflow end relative to outer support covers flow blocking film.The artificial heart valve includes the artificial heart valve stent and artificial valve leaflet fixedly connected in inner support.The artificial heart valve stent and artificial heart valve can reduce the risk of paravalvular leakage while being stably positioned in heart.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

This invention provides a transcatheter valve prosthesis comprising a stent, a prosthetic valve component, and a paravalvular leakage prevention component. The paravalvular leakage prevention component is coupled to the stent and includes an inner skirt, an outer covering, a lumen, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer covering surrounds an outer surface of the stent and has an inflow end and a downstream end, the inflow end being coupled to the inflow end of the inner skirt. The lumen is formed between the outer surface of the inner skirt and the inner surface of the outer covering. The opening is disposed between the inner skirt and the outer covering. The one-way valve includes a flap at the opening, the flap being configured to open to allow blood to flow into the lumen but prevent blood from flowing out of the lumen.

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.

The present application relates to the technical field of medical devices, and provides a valve prosthesis, comprising a stent and a bag body arranged on the stent. The stent comprises an extension body that can be located on one side of a cardiac valve annulus, and the side of the extension body opposite to the cardiac valve annulus is an outer side. The bag body is located on the outer side of the extension body. The bag body is provided with an opening that allows blood to enter. By means of the technical solutions of the present application, the valve prosthesis can better fit the cardiac valve annulus, thereby solving the problem of perivalvular leakage.

The invention provides an artificial heart valve stent and an artificial heart valve prosthesis, and relates to the field of medical instruments, the artificial heart valve stent comprises a stent main body, a stent outflow section and a bending arm; the near end of the stent outflow section and the far end of the stent main body are integrally formed; the bent arm is arranged on the support body and extends in the circumferential direction of the support body, the bent arm is provided with a bent arm connecting end and a bent arm free end in the circumferential direction of the support body, the bent arm connecting end and the support body are fixedly connected or integrally formed, and the bent arm free end and the support body are spaced. The heart valve prosthesis prosthesis comprises an inner stent and an outer stent, and the inner stent or the outer stent is the heart valve prosthesis stent. According to the artificial valve, the risk of perivalvular leakage after the artificial valve is implanted in an interventional mitral valve replacement operation can be reduced.

The application discloses a heart valve stent and a prosthesis thereof, and the heart valve stent comprises a stent body, the stent body has an inflow tract and an outflow tract which are axially connected, the inflow tract and the outflow tract are both composed of mesh structure units which are connected with each other, the stent body is provided with a grab ear structure which extends towards the proximal end of the inflow tract, the proximal end of the inflow tract is outwardly folded, and a gap is formed between the proximal end of the grab ear structure and the inflow tract. The heart valve prosthesis provided by the application has the advantages that the diameter of the valve leaflet is small, the fatigue resistance of the valve is good, the outflow tract obstruction and the paravalvular leakage can be avoided or reduced, the diameter of the catheter of the conveying system adapted to the application is small, the conveying difficulty and the risk of blood vessel injury are reduced, and the phenomenon of systolic anterior motion (SAM) can be reduced, so that the risk of left ventricular outflow tract obstruction is reduced.

The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

A prosthetic heart valve for replacing a native valve includes a stent extending between a proximal end and a distal end and including a plurality of struts forming cells, the stent having a collapsed condition and an expanded condition. At least one runner is coupled a cell, the at least one runner being configured to transition from a first configuration to a second configuration when the stent moves from the collapsed condition to the expanded condition, the at least one runner projecting radially outwardly from the cell in the second configuration. A valve assembly is disposed within the stent, the valve assembly including a plurality of leaflets, a cuff at least partially disposed on a luminal surface of the stent, and a covering material disposed on an abluminal surface of the stent and covering the at least one runner in the second configuration.

A prosthetic heart valve for replacing a native valve includes a collapsible and expandable stent having a proximal end and a distal end, the stent being formed of a plurality of struts forming cells. A valve assembly is disposed within the stent, the valve assembly including a plurality of leaflets and a cuff. At least one runner is coupled to a cell and configured to transition from a first configuration to a second configuration when the stent moves from the collapsed condition to the expanded condition.

This application belongs to the field of medical devices, specifically relating to a valve prosthesis and its delivery system for preventing paravalvular leakage. It includes a leak-proof device and a stent. The stent includes a valve suture segment. The leak-proof device is connected to the proximal portion of the stent. The leak-proof device has an irregular structure and has a first form and a second form. When the leak-proof device is in the first form, it is offset from the valve suture segment in the axial direction. When the leak-proof device changes from the first form to the second form, it returns to the preset form along a preset path towards the distal end of the stent, and at least a portion of the leak-proof device overlaps with the valve suture segment in the axial direction. This invention achieves a significant reduction in tube diameter and can specifically adapt to the physiological structure of the autologous valve, allowing it to better fit the autologous valve annulus and atrial tissue, effectively preventing regurgitation.

The application relates to a paravalvular leakage plugging device applied to a prosthetic valve with an annular body, comprising biodegradable foam attached to at least a section of the outer periphery of the annular body, which is water-swellable and has a first degradation rate; and a film wrapping the biodegradable foam, which is configured as a porous film and has a second degradation rate; when the biodegradable foam swells upon contact with water, the film does not constrain the swelling of the biodegradable foam, and the first degradation rate is different from the second degradation rate. The paravalvular leakage plugging device adopts biodegradable foam to plug the leakage, compared with a traditional metal plugging device, does not cause damage to the heart tissue and the valve, reduces the risk of complications, and meanwhile, the biodegradable foam gradually degrades after completing plugging, so that no residues are left in the human body, further reducing the long-term risk.

The utility model provides a ball expansion valve. The ball expansion valve comprises a valve frame, a skirt cloth assembly and at least two valve leaflets. The valve frame is a cylindrical support; the surface of the valve frame is coated with a polyurethane film layer; the skirt cloth assembly comprises inner skirt cloth and outer skirt cloth, the inner skirt cloth is arranged on the inner circumferential surface of the valve frame, and the outer skirt cloth is arranged on the outer circumferential surface of the valve frame; the inner skirt cloth and the outer skirt cloth are made of polyurethane, polyethylene terephthalate or polytetrafluoroethylene materials; all the valve leaflets are arranged in the valve frame; the valve leaflet is made of a polyurethane material; and the inner skirt cloth is connected with the valve leaflet. The utility model provides the ball-expanded valve which is resistant to fatigue, calcification, blood coagulation and perivalvular leakage, and has good mechanical property and biocompatibility.

A prosthetic mitral valve includes a stent frame and an anchor assembly coupled to and peripherally surrounding the stent frame. The anchor assembly includes atrial anchors on the inflow end, ventricular anchors on the outflow end, and a central waist portion disposed therebetween. The anchor assembly generally defines an hourglass shape wherein the atrial and ventricular anchors flare radially outward and the central waist portion has a relatively smaller diameter. The prosthetic valve may include a gasket disposed peripherally around the central waist portion to seal the space between the body of the valve and the native valve annulus to prevent paravalvular leakage without increasing the profile of the valve to allow for smooth insertion into and deployment from a delivery device. The prosthetic valve may alternatively include a sealing fabric surrounding the anchor assembly defining a radial protrusion around the central waist portion to seal the native annulus.

A system and method for restoring (e.g., replacing) a defective heart valve of a patient. A delivery system is manipulated to percutaneously deliver and implant a stented prosthetic heart valve to a native heart valve. A post-dilatation balloon is percutaneously delivered to the implantation site, and a compliant segment thereof is arranged within a region of the implanted prosthesis. The balloon is inflated such that the compliant segment expands and contacts the prosthesis, expanding a remodeling region of the prosthesis to a remodeled state. With these and related techniques, remodeling of an implanted, stented prosthetic heart valve to better match the native valve shape is possible, providing many benefits such as reducing the risk of paravalvular leaks.

The application provides a kind of replacement valve device and support by catheterization, it is related to heart valve technical field.The replacement valve support by catheterization includes support main body and anchoring structure.The support main body is the cylinder frame structure that can be radially compressed and unfolded, with the state of pressing and unfolding state;The anchoring structure is the closed frame structure that is set around the outer periphery of support main body;When support main body is in the unfolded state, anchoring structure expands towards the outside of support main body, so that support main body is anchored.The application can solve the problem of insufficient anchoring force, anchoring part deviation in prior art, leading to artificial valve displacement, unable to guarantee the fit of artificial valve ring and autologous valve ring, thereby leading to perivalvular leakage or causing other complications, the closed frame structure exists mutual force, can provide more stable support force for support main body, effectively prevent the circumferential displacement of support main body.

The present invention provides a heart valve prosthesis, relating to the field of medical device technology. The heart valve prosthesis comprises: an inner stent and an outer stent; the inner stent comprises: a thin channel and a thick channel; a prosthetic valve leaflet is arranged in the thin channel; the top opening of the outer stent is sutured to the thin channel through a membrane, and the bottom opening of the outer stent is sutured to the thick channel, and the outer stent acts as a buffer to prevent the prosthetic valve leaflet from being damaged by the heart contraction squeezing the thin channel; the outer stent is provided with an inward depression, the top of the depression is covered with a brim, and the depression is used to avoid the patient's native tissue; the brim covers the top of the depression and acts as a seal to prevent the heart valve prosthesis from leaking around the depression; the inner stent and / or the outer stent are provided with elastic hooks, which fix the native valve leaflet, playing both a positioning role and a sealing role to prevent paravalvular leakage; the heart valve prosthesis is implanted in the patient's body through minimally invasive surgery, has a long service life, causes little damage to surrounding tissue, is easy to operate, and has few complications.

The present invention relates to an artificial valve anchoring device and assembly, and a transcatheter heart valve replacement system. During transcatheter heart valve replacement, a capture ring and the artificial valve anchoring device are first implanted sequentially. An inflow end of the artificial valve anchoring device is provided with a skirt portion, which can address the problems of perivalvular leakage and regurgitation even before the artificial valve is released. The artificial valve anchoring device is also provided with two connecting arms, which are capable of penetrating gaps at the commissures of native valve leaflets and connecting to the capture ring, without affecting the function or movement of the native valve leaflets. A main body part of the artificial valve anchoring device can cooperate with the capture ring to simplify the patient's complex mitral / tricuspid valve structure into a standardized circular channel, providing a stable anchoring pathway for the artificial valve. The main body part and the artificial valve are connected by means of an interference fit. During subsequent implantation of the artificial valve, the release height of the artificial valve can also be adjusted according to the patient's actual situation.

Embodiments herein include a cardiac stent-valve for transcatheter delivery being compressible to a compressed state for delivery, and expandable to an expanded state for implantation. The stent-valve including a stent with an axial inflow end and an axial outflow end, a plurality of leaflets arranged within the stent, and a sealing skirt for reduction or prevention of paravalvular leakage. In the expanded state, the sealing skirt includes a tubular inner wall and at least one pocket which is positioned on the tubular inner wall and comprises an outer wall which extends radially outward from the tubular inner wall. The pocket is configured to be distended radially outward in response to inflow of blood in the expanded state. In the expanded state, the outer wall of the pocket includes one or more pre-shaped bulges which extend radially outward from the outer wall of the pocket. Other embodiments are also included herein.