105 results about "Perivalvular Leak" patented technology

According to the anchoring piece, the restraining device, the conveying system and the conveying method, the anchoring piece adopts an anchoring clamp clamping mode, can adapt to more pathological structures, and can effectively treat aortic valve regurgitation (or aortic valve divalvular and tetravalvular deformity accompanied by aortic valve divalvular and tetravalvular deformity) patients; the protruding anchor is arranged to hang or carry the autologous valve leaflet, valve displacement is prevented, and the perivalvular leakage risk is reduced. The restraining device is provided with a restraining part, the anchoring part is sleeved with a restraining section of the restraining part in an annular shape, a scaling section is connected with the restraining section and arranged in the releasing pipe in a penetrating mode, and the restraining force of the restraining section on the anchoring part is controlled by controlling the scaling section so as to control the releasing speed of the anchoring part. The delivery system optimizes the structure and the function of the whole system, a lumen gap can be properly widened, emptying and water passing are facilitated, the delivery system has better control force when the artificial valve is released due to introduction of the restraining device, and it is guaranteed that when the anchoring piece reaches the lesion position, the anchoring piece is slowly placed, and the aorta and the sinus floor are prevented from being damaged.

The invention provides a mitral valve replacement system in the technical field of medical instruments, and the mitral valve replacement system comprises a valve stent, a fixing ring and a shearing part, the fixing ring is arranged around the end face of the valve stent, and the shearing part is oppositely arranged on one side of the valve stent. The fixing ring surrounds the groove in the end face of the valve support to limit the moving direction of the valve support, so that the valve support is stably located at the native mitral valve ring, and the butterfly buckle is arranged on the valve support to buckle and clamp the native mitral valve leaflet. The fixing ring is tied and hooped at the groove in the end face of the valve support of the artificial heart valve, so that the artificial heart valve is stably positioned at the original mitral valve annulus, displacement of the artificial heart valve caused by external force factors such as blood flow impact force is prevented, and then the perivalvular leakage problem caused by displacement is avoided; the native mitral valve anterior leaflet is cut open through the cutting part, and then the cut native mitral valve anterior leaflet is buckled and clamped through the butterfly buckle, so that blood flowing through the native mitral valve anterior leaflet smoothly circulates, and the problem that the left ventricular outflow tract is obstructed is solved.

The present invention relates to a valve stent and a prosthetic valve. The prosthetic valve comprises a skirt, a prosthetic valve leaflet, and the valve stent; the prosthetic valve leaflet is arranged on the inner side of the valve stent and connected to the skirt and the valve stent; the skirt comprises an inner skirt and an outer skirt; the valve stent comprises a flange part and a main body part; the flange part is connected to an inflow end of the main body part, and the flange part comprises an inner layer structure and an outer layer structure arranged from inside to outside; an annular curved surface defined by the inner layer structure does not overlap an annular curved surface defined by the outer layer structure, so that the flange part forms a three-dimensional structure in which the inner layer and the outer layer are distributed in a staggered manner; the outer skirt is connected to the inner skirt along the outer layer structure to form at least one pocket; the pocket defines a pocket opening; and the pocket opening is located on the outer side of the valve stent and arranged towards an outflow end of the main body part. Therefore, when the heart contracts, the pocket expands to fill a gap between the flange part and the native tissue, so that the liquid is prevented from flowing back around the prosthetic valve, better preventing perivalvular leakage.

The invention provides a double-hole mitral valve replacement implant which comprises a wrapping cloth outer support and an inner valve support, the wrapping cloth outer support is arranged on the periphery of the inner valve support in a sleeving mode, and the inner valve support comprises a first inner support and a second inner support which are arranged side by side. A first bioprosthetic valve and a second bioprosthetic valve are respectively arranged in the first inner stent and the second inner stent; a containing gap is formed among the wrapping cloth outer support, the first inner support and the second inner support, a flow blocking skirt edge is arranged in the containing gap, one side of the flow blocking skirt edge is connected with the inner wall of the wrapping cloth outer support, and the other side of the flow blocking skirt edge is arranged on the periphery of the first inner support and the periphery of the second inner support in an attached mode. A tightening line is arranged on the edge, close to the first inner support or the second inner support, of the flow blocking skirt edge in a penetrating mode. The problems of perivalvular leakage and leakage of a fit clearance between the inner support and the outer support are effectively solved, and high safety is achieved.

A prosthetic heart valve for replacing a native valve includes a stent extending between a proximal end and a distal end and including a plurality of struts forming cells, the stent having a collapsed condition and an expanded condition. At least one runner is coupled a cell, the at least one runner being configured to transition from a first configuration to a second configuration when the stent moves from the collapsed condition to the expanded condition, the at least one runner projecting radially outwardly from the cell in the second configuration. A valve assembly is disposed within the stent, the valve assembly including a plurality of leaflets, a cuff at least partially disposed on a luminal surface of the stent, and a covering material disposed on an abluminal surface of the stent and covering the at least one runner in the second configuration.

The application provides a kind of replacement valve device and its support by catheterization, it is related to heart valve technical field.The replacement valve support by catheterization includes support main body, anchoring structure, skirt support structure and sealing membrane.The sealing membrane is circumferentially closed cylindrical structure, sealing membrane includes the first sealing section and the second sealing section being arranged along the axial direction and being connected with each other, the first sealing section is tightly arranged on part or all of skirt support structure, the second sealing section is tightly arranged on part or all of support main body;Sealing membrane is arranged on the inner side and / or outer side of skirt support structure and support main body.The application can solve the problem that sealing membrane and valve support do not fit in the prior art, poor sealing, leading to sealing membrane in blood, leading to paravalvular leakage or causing other complications, with high degree of fit, good sealing, can avoid sealing membrane in blood, effectively avoid paravalvular leakage or cause other complications.

The invention relates to the technical field of medical instruments and discloses a plugging device and a plugging system, the plugging device is of a semi-closed structure, a containing cavity is formed in the plugging device, an opening of the plugging device communicates with the containing cavity, the opening is suitable for allowing fluid to flow into the containing cavity, and the plugging device is suitable for expanding under the pressure of the fluid. The plugging device can be implanted between a valve support and a heart valve ring, an opening of the plugging device faces the blood inflow side, namely the far-end side, blood flows into the plugging device through the opening of the plugging device in the flowing process, and along with increase of the blood in the plugging device, the plugging device can be used for plugging the heart valve ring. The plugging device expands after being subjected to blood pressure and can be attached to the valve stent and the heart valve ring, so that a gap between the valve stent and the heart valve ring is plugged, and the problem of perivalvular leakage can be relieved; the plugging device expands by means of blood flowing in the body, so that the plugging device can adapt to the gap between the valve stent and the heart valve ring, and the plugging effect on perivalvular leakage can be improved.

The invention relates to the technical field of medical instruments, and provides a valve prosthesis and a preparation method thereof.The valve prosthesis comprises a valve frame and a flexible leakage-proof part arranged on the valve frame; the direction, where blood can flow, of the valve prosthesis is defined as the vertical direction, the valve frame comprises a positioning part which can be positioned on the upper side of a human heart valve ring, and the flexible leakage-proof piece comprises a containing part which can be filled with blood and is located on the lower side of the positioning part after being filled with the blood. The containing part comprises an inward extending section extending inwards in the radial direction of the valve frame and an edge part located on the edge of the inward extending section, at least part of the edge part extends outwards in the radial direction of the valve frame to form an outward extending section, and the outward extending section is located on the upper side of the inward extending section. According to the technical scheme, the problem of perivalvular leakage is solved.

The present invention relates to an artificial heart valve, which comprises a valve stent, a first sealing membrane, a second sealing membrane, valve leaflets and valve leaflet anchoring members. The valve stent includes an inflow section and an outflow section; the first sealing membrane is attached to the outer side of the valve stent and comprises a hydrophilic swelling material, which can absorb liquid and swell after contacting with blood, for reducing paravalvular leakage; the second sealing membrane is arranged on the outer side of the first sealing membrane and at least covers all regions corresponding to the outer surface of the inflow section, for increasing the friction with the native valve leaflets; the valve leaflets are arranged inside the valve stent for controlling the unidirectional flow of blood; the valve leaflet anchoring members are spiral and can be coiled outside the mitral / tricuspid chordae tendineae plexus and interact with the valve stent. By providing the first sealing membrane and the second sealing membrane, the artificial heart valve of the present invention can better fit with the native tissue after being implanted into the mitral / tricuspid valve, so as to effectively prevent the occurrence of paravalvular leakage.

A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

The present invention provides a series of new percutaneous concepts of paravalvular repairs including identifying the leak location, several repair techniques and finally built-in means for leak prevention, built on percutaneous valves. A catheter-delivered device locates cavities occurring between a prosthetic valve (250) and the wall of the body vessel where the valve is implanted, the cavities producing paravalvular leaks during diastole, the device comprising at least one of a plurality of flexible wires, the wire having attached to it a balloon, wherein the balloon is pulled by the leak through the cavity and wherein the wire then serves to mark the cavity location.

This invention discloses a novel valve stent and artificial heart valve, belonging to the field of medical device technology. The valve stent has a hollow, symmetrical, mesh-like tubular structure, with a first layer of hexagonal mesh groups, a second layer of polygonal mesh groups, and a third layer of polygonal mesh groups arranged sequentially from the outflow end to the inflow end. The stent has a small overall mesh count and symmetrical structure, resulting in uniform deformation during compression and expansion. It exhibits excellent radial support and minimal expansion rebound, significantly reducing the risk of paravalvular leakage. While maintaining radial support, this invention can reduce the stent strut width to 0.2–0.4 mm, and the minimum outer diameter of the valve after compression can reach 2.5–4.5 mm. Simultaneously, the overall length change during stent compression and expansion is minimal, greatly improving the smoothness of vascular delivery and the accuracy of valve implantation positioning. This meets the clinical needs of transcatheter aortic valve replacement surgery, enhancing the safety and effectiveness of artificial heart valve implantation.

The invention discloses an integrated heart valve stent capable of preventing coronary artery opening blockage, and relates to the field of heart valve stent integrated heart valve stents. The integrated heart valve stent capable of preventing the coronary artery opening from being blocked comprises a main stent body and a plurality of sets of positioning pieces used for being inserted into the sinus floor of a heart valve. The main body support comprises multiple sets of full supporting pieces and multiple sets of semi-supporting pieces which are sequentially connected, and the multiple sets of full supporting pieces which are sequentially connected are arranged between the sets of semi-supporting pieces. Coronary artery passing holes and supporting holes are formed in each group of semi-supporting pieces. And the positioning piece is connected with the full supporting piece or the semi-supporting piece. By means of the arrangement, the coronary artery opening is prevented from being blocked while the supporting force of the main body support is guaranteed, a follow-up coronary artery repairing instrument can be allowed to enter from the coronary artery passing hole, and meanwhile the risk of perivalvular leakage is reduced.

The invention discloses an artificial heart valve device and an implantation method, and belongs to the technical field of medical instruments.The artificial heart valve device comprises a valve support, a skirt edge and an artificial valve, the valve support comprises a control support, a body and at least three positioning parts, the artificial valve is installed on the control support, the skirt edge is connected outside the body in a sleeving mode, and the positioning parts are arranged on the skirt edge; the first end of the positioning piece is fixed to the control support, and the second end of the positioning piece is matched with the top of the skirt edge. The three positioning pieces are distributed in the circumferential direction of the valve support and used for supporting the top of the skirt edge. When the valve support is in a natural state, the diameter of the top of the skirt is larger than that of the waist of the skirt. The three positioning pieces unfold the top of the skirt edge, the top of the skirt edge is in a funnel shape after being unfolded, the conveying mechanism is pushed towards the left ventricle, in this way, it can be ensured that the top of the skirt edge abuts against the autologous valve, a sealing area is formed between the top of the skirt edge and the autologous valve, and by means of the positioning sealing area, perivalvular leakage can be prevented.

A catheter system (1, 1 ') for interventional procedures within a patient's heart, vasculature and / or an implant (42) secured at a patient's heart or vasculature (50, 51, 52) is described, comprising a bendable and / or steerable extension arm (12) and a guide sheath (10) having a distal section, which allows for precise and effective localization of perivalvular leaks and deployment of occlusion members. The extension arm is fixed at a distal end of the distal section of the guide sheath, or is configured to move along the guide sheath such that the extension arm protrudes from the distal end of the distal section in an operative position, where the extension arm has a lumen through which the guidewire (17) can be manipulated and which defines a longitudinal axis (15), where the catheter system further comprises at least one alignment member (20, 120, 220, 320, 420, 520), where the alignment member (20, 120, 220, 320, 420, 520) is configured to align the guidewire (17) to the extension arm (20, 120, 220, 320, 420, 520). And an alignment member having a collapsed state and configured to be deployed to a deployed state in which the alignment member is attached to the guide sheath at a predetermined position within the distal section but proximally from a distal end thereof, or the alignment member is configured to advance along the guide sheath to a predetermined position within the distal section, wherein the alignment component comprises a plurality of struts (21, 28) distributed over a circumference, and wherein each strut of the plurality of struts extends at least in sections into a radial direction and / or is inclined with respect to the longitudinal axis in the deployed state, thereby creating a radially outwardly directed force and supporting the alignment component on the heart, vasculature and / or implant of the patient. Furthermore, a method for closing at least one perivalvular leak (53) is interpreted.

A prosthetic heart valve includes a collapsible stent and a valve assembly disposed within the stent. A first cuff is disposed adjacent the stent. A second cuff having a distal edge facing the outflow end of the stent is disposed about the stent radially outward of the first cuff and the stent. The stent may include a plurality of fingers each having a first end coupled to a corresponding cell of the stent and a free end adapted to extend radially outward of the corresponding cell. The distal edge of the second cuff may be coupled to the fingers at spaced locations around the circumference of the stent to position the distal edge radially outward from the corresponding cells at the spaced locations. Various stent struts may be tapered to reduce the stent circumference in the collapsed condition, and to improve the fatigue resistance and / or bendability of the stent.

The utility model relates to the technical field of medical instruments, in particular to an artificial valve clamping piece and a conveying system. The artificial valve clamping piece comprises a clamping piece body, a connecting wire and a traction structure, the clamping piece body comprises a pipe body and a plurality of through holes formed in the pipe body, the pipe body is in a wave shape, and the two ends of the pipe body are closed to form a ring shape; the connecting wire penetrates into the tube body, and the end part of the connecting wire penetrates through the through hole in the tube body and then is suitable for being connected with the artificial valve; the traction structure comprises a traction wire, the traction wire is arranged in the pipe body in a penetrating mode through a through hole in the pipe body, and the traction wire is suitable for being connected with a conveying system. The clamping piece is of a periodic wave-shaped or fluctuating annular structure, can be fixed to the periphery of the outer surface of the artificial valve, can be radially compressed and expanded according to the size of the internal artificial valve, and is matched with the artificial valve to clamp the autologous valve leaflet, so that the artificial valve can be stably anchored at an accurate position without displacement, and meanwhile, the clamping piece can be used for clamping the autologous valve leaflet. The clamping device can reduce the occurrence risk of perivalvular leakage.

The present application relates to a kind of artificial heart valve stents and artificial heart valve.The artificial heart valve stent includes inner support and outer support.Inclination from inflow end to outflow end, first portion and second portion are included in sequence in inner support, the radial dimension of first portion is greater than the radial dimension of second portion, at least a portion of second portion is nested in outer support, and at least a portion of first portion extends to inflow end relative to outer support, and the portion of first portion extending to inflow end relative to outer support covers flow blocking film.The artificial heart valve includes the artificial heart valve stent and artificial valve leaflet fixedly connected in inner support.The artificial heart valve stent and artificial heart valve can reduce the risk of paravalvular leakage while being stably positioned in heart.

The present invention provides a valve stent and a usage method thereof for bicuspid aortic valve stenosis, comprising an ascending aorta contact area, a connecting body, a valve support area and a valve prosthesis suture part; the ascending aorta contact area is in an annular shape, a honeycomb-like structure formed by arranging and connecting a plurality of regular hexagons; the valve support area is in an elliptical annular shape, a grid structure formed by arranging and connecting a plurality of rhombuses. The present invention enhances the radial stiffness of the stent, thereby improving its radial support capacity; the valve support area is designed as an elliptical ring structure, and when implanting the artificial heart valve stent, the long-axis implantation angle of the valve stent is kept perpendicular to the long axis of the valve annulus, and by using the mutual coupling effect between the two, the cross-sectional shape of the expanded valve stent is finally circular, which improves the problem of poor expansion during the implantation of the valve stent and the elliptization after the valve stent is implanted, thereby reducing the occurrence of paravalvular leakage, with uniform stress and extended service life.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

This invention provides a transcatheter valve prosthesis comprising a stent, a prosthetic valve component, and a paravalvular leakage prevention component. The paravalvular leakage prevention component is coupled to the stent and includes an inner skirt, an outer covering, a lumen, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer covering surrounds an outer surface of the stent and has an inflow end and a downstream end, the inflow end being coupled to the inflow end of the inner skirt. The lumen is formed between the outer surface of the inner skirt and the inner surface of the outer covering. The opening is disposed between the inner skirt and the outer covering. The one-way valve includes a flap at the opening, the flap being configured to open to allow blood to flow into the lumen but prevent blood from flowing out of the lumen.

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.

The present application relates to the technical field of medical devices, and provides a valve prosthesis, comprising a stent and a bag body arranged on the stent. The stent comprises an extension body that can be located on one side of a cardiac valve annulus, and the side of the extension body opposite to the cardiac valve annulus is an outer side. The bag body is located on the outer side of the extension body. The bag body is provided with an opening that allows blood to enter. By means of the technical solutions of the present application, the valve prosthesis can better fit the cardiac valve annulus, thereby solving the problem of perivalvular leakage.

The utility model provides a sealing component and an artificial heart valve. The artificial heart valve comprises a support, an artificial valve leaflet and the sealing component. The sealing component is used for being connected with the support and used for wrapping at least part of the outer contour of the support. At least partial area of the sealing component comprises a base layer and an extension layer, and the extension layer is fixed to the outer surface of the base layer and surrounds the whole perimeter of the base layer. The extension layer can deform so as to be used for filling a gap between the base layer and the target tissue. The sealing component of the artificial heart valve can fill the gap between the target tissue and the base layer and is tightly attached to the target tissue, so that perivalvular leakage is effectively prevented.

The present invention relates to a valve stent and an artificial valve. The artificial valve includes a skirt, artificial valve leaflets, and a valve stent. The artificial valve leaflets are disposed inside the valve stent and are connected to the skirt and the valve stent. The skirt includes an inner skirt and an outer skirt. The valve stent includes a flange portion and a main body portion. The flange portion is connected to the inflow end of the main body portion. The flange portion includes an inner layer structure and an outer layer structure arranged from the inside to the outside. The annular surface defined by the inner layer structure does not overlap with the annular surface defined by the outer layer structure, so that the flange portion forms a three-dimensional structure in a manner of internal and external staggered layers. The outer skirt is connected to the inner skirt along the outer layer structure and forms at least one pocket. The pocket is defined with a pocket opening, and the pocket opening is located outside the valve stent and is arranged toward the outflow end of the main body portion. Thus, when the heart contracts, the gap between the flange portion and the native tissue can be filled by the expansion of the pocket, so that the liquid cannot flow back from around the artificial valve, and paravalvular leakage can be better prevented.

The invention provides an artificial heart valve stent and an artificial heart valve prosthesis, and relates to the field of medical instruments, the artificial heart valve stent comprises a stent main body, a stent outflow section and a bending arm; the near end of the stent outflow section and the far end of the stent main body are integrally formed; the bent arm is arranged on the support body and extends in the circumferential direction of the support body, the bent arm is provided with a bent arm connecting end and a bent arm free end in the circumferential direction of the support body, the bent arm connecting end and the support body are fixedly connected or integrally formed, and the bent arm free end and the support body are spaced. The heart valve prosthesis prosthesis comprises an inner stent and an outer stent, and the inner stent or the outer stent is the heart valve prosthesis stent. According to the artificial valve, the risk of perivalvular leakage after the artificial valve is implanted in an interventional mitral valve replacement operation can be reduced.

The present application belongs to the field of medical devices, and specifically relates to an artificial valve prosthesis with a sealing device, comprising a stent, an artificial valve leaflet and a sealing device, wherein the artificial valve leaflet is arranged in the stent, and the sealing device is at least partially arranged outside the stent, the sealing device comprises a sealing frame and a leak-proof component connected to the sealing frame, the sealing frame is connected to the stent, and the stent provides a fulcrum for the sealing frame, the sealing frame comprises a first curved segment and a second curved segment, after the stent is installed in place, at least a portion of the first curved segment is in contact with the heart tissue wall, when the heart tissue squeezes the sealing device, the first curved segment rotates around the fulcrum toward the center of the stent, and the first curved segment drives the second curved segment to rotate in the same direction, so that the sealing device is always in contact with the native valve ring to prevent the problem of paravalvular leakage.

The application discloses a heart valve stent and a prosthesis thereof, and the heart valve stent comprises a stent body, the stent body has an inflow tract and an outflow tract which are axially connected, the inflow tract and the outflow tract are both composed of mesh structure units which are connected with each other, the stent body is provided with a grab ear structure which extends towards the proximal end of the inflow tract, the proximal end of the inflow tract is outwardly folded, and a gap is formed between the proximal end of the grab ear structure and the inflow tract. The heart valve prosthesis provided by the application has the advantages that the diameter of the valve leaflet is small, the fatigue resistance of the valve is good, the outflow tract obstruction and the paravalvular leakage can be avoided or reduced, the diameter of the catheter of the conveying system adapted to the application is small, the conveying difficulty and the risk of blood vessel injury are reduced, and the phenomenon of systolic anterior motion (SAM) can be reduced, so that the risk of left ventricular outflow tract obstruction is reduced.

The present invention discloses an artificial heart valve prosthesis and its stent. The artificial heart valve stent includes an outer stent and an inner stent; the inner stent and the outer stent are fixedly connected; the outer stent has an outer inflow channel structure and an outer outflow channel structure that are axially connected; the inner stent has an inner inflow channel structure and an inner outflow channel structure that are axially connected and are located inside the outer stent in the radial direction, and an anchoring structure is provided on the outer side of the inner stent. For the artificial heart valve prosthesis and its stent provided by the present invention, the inner stent bears the artificial valve leaflets and has high stiffness and small diameter, which can reduce the area of the artificial valve leaflets, lower the height required for the opening and closing movement of the valve leaflets, and improve the lifespan of the valve leaflets; the outer stent has relatively low stiffness and large diameter, which can prevent paravalvular leakage. The anchoring structure is connected to the inner stent, and the anchoring force for preventing the movement of the prosthetic valve is mainly borne by the inner stent with stronger stiffness, thereby improving the lifespan of the stent.