38 results about "Perivalvular Leak" patented technology

A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

The present invention provides a series of new percutaneous concepts of paravalvular repairs including identifying the leak location, several repair techniques and finally built-in means for leak prevention, built on percutaneous valves. A catheter-delivered device locates cavities occurring between a prosthetic valve (250) and the wall of the body vessel where the valve is implanted, the cavities producing paravalvular leaks during diastole, the device comprising at least one of a plurality of flexible wires, the wire having attached to it a balloon, wherein the balloon is pulled by the leak through the cavity and wherein the wire then serves to mark the cavity location.

This invention discloses a novel valve stent and artificial heart valve, belonging to the field of medical device technology. The valve stent has a hollow, symmetrical, mesh-like tubular structure, with a first layer of hexagonal mesh groups, a second layer of polygonal mesh groups, and a third layer of polygonal mesh groups arranged sequentially from the outflow end to the inflow end. The stent has a small overall mesh count and symmetrical structure, resulting in uniform deformation during compression and expansion. It exhibits excellent radial support and minimal expansion rebound, significantly reducing the risk of paravalvular leakage. While maintaining radial support, this invention can reduce the stent strut width to 0.2–0.4 mm, and the minimum outer diameter of the valve after compression can reach 2.5–4.5 mm. Simultaneously, the overall length change during stent compression and expansion is minimal, greatly improving the smoothness of vascular delivery and the accuracy of valve implantation positioning. This meets the clinical needs of transcatheter aortic valve replacement surgery, enhancing the safety and effectiveness of artificial heart valve implantation.

The invention discloses an integrated heart valve stent capable of preventing coronary artery opening blockage, and relates to the field of heart valve stent integrated heart valve stents. The integrated heart valve stent capable of preventing the coronary artery opening from being blocked comprises a main stent body and a plurality of sets of positioning pieces used for being inserted into the sinus floor of a heart valve. The main body support comprises multiple sets of full supporting pieces and multiple sets of semi-supporting pieces which are sequentially connected, and the multiple sets of full supporting pieces which are sequentially connected are arranged between the sets of semi-supporting pieces. Coronary artery passing holes and supporting holes are formed in each group of semi-supporting pieces. And the positioning piece is connected with the full supporting piece or the semi-supporting piece. By means of the arrangement, the coronary artery opening is prevented from being blocked while the supporting force of the main body support is guaranteed, a follow-up coronary artery repairing instrument can be allowed to enter from the coronary artery passing hole, and meanwhile the risk of perivalvular leakage is reduced.

A prosthetic heart valve includes a collapsible stent and a valve assembly disposed within the stent. A first cuff is disposed adjacent the stent. A second cuff having a distal edge facing the outflow end of the stent is disposed about the stent radially outward of the first cuff and the stent. The stent may include a plurality of fingers each having a first end coupled to a corresponding cell of the stent and a free end adapted to extend radially outward of the corresponding cell. The distal edge of the second cuff may be coupled to the fingers at spaced locations around the circumference of the stent to position the distal edge radially outward from the corresponding cells at the spaced locations. Various stent struts may be tapered to reduce the stent circumference in the collapsed condition, and to improve the fatigue resistance and / or bendability of the stent.

The utility model relates to the technical field of medical instruments, in particular to an artificial valve clamping piece and a conveying system. The artificial valve clamping piece comprises a clamping piece body, a connecting wire and a traction structure, the clamping piece body comprises a pipe body and a plurality of through holes formed in the pipe body, the pipe body is in a wave shape, and the two ends of the pipe body are closed to form a ring shape; the connecting wire penetrates into the tube body, and the end part of the connecting wire penetrates through the through hole in the tube body and then is suitable for being connected with the artificial valve; the traction structure comprises a traction wire, the traction wire is arranged in the pipe body in a penetrating mode through a through hole in the pipe body, and the traction wire is suitable for being connected with a conveying system. The clamping piece is of a periodic wave-shaped or fluctuating annular structure, can be fixed to the periphery of the outer surface of the artificial valve, can be radially compressed and expanded according to the size of the internal artificial valve, and is matched with the artificial valve to clamp the autologous valve leaflet, so that the artificial valve can be stably anchored at an accurate position without displacement, and meanwhile, the clamping piece can be used for clamping the autologous valve leaflet. The clamping device can reduce the occurrence risk of perivalvular leakage.

The present application relates to a kind of artificial heart valve stents and artificial heart valve.The artificial heart valve stent includes inner support and outer support.Inclination from inflow end to outflow end, first portion and second portion are included in sequence in inner support, the radial dimension of first portion is greater than the radial dimension of second portion, at least a portion of second portion is nested in outer support, and at least a portion of first portion extends to inflow end relative to outer support, and the portion of first portion extending to inflow end relative to outer support covers flow blocking film.The artificial heart valve includes the artificial heart valve stent and artificial valve leaflet fixedly connected in inner support.The artificial heart valve stent and artificial heart valve can reduce the risk of paravalvular leakage while being stably positioned in heart.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

This invention provides a transcatheter valve prosthesis comprising a stent, a prosthetic valve component, and a paravalvular leakage prevention component. The paravalvular leakage prevention component is coupled to the stent and includes an inner skirt, an outer covering, a lumen, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer covering surrounds an outer surface of the stent and has an inflow end and a downstream end, the inflow end being coupled to the inflow end of the inner skirt. The lumen is formed between the outer surface of the inner skirt and the inner surface of the outer covering. The opening is disposed between the inner skirt and the outer covering. The one-way valve includes a flap at the opening, the flap being configured to open to allow blood to flow into the lumen but prevent blood from flowing out of the lumen.

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.

The present application relates to the technical field of medical devices, and provides a valve prosthesis, comprising a stent and a bag body arranged on the stent. The stent comprises an extension body that can be located on one side of a cardiac valve annulus, and the side of the extension body opposite to the cardiac valve annulus is an outer side. The bag body is located on the outer side of the extension body. The bag body is provided with an opening that allows blood to enter. By means of the technical solutions of the present application, the valve prosthesis can better fit the cardiac valve annulus, thereby solving the problem of perivalvular leakage.

The invention provides an artificial heart valve stent and an artificial heart valve prosthesis, and relates to the field of medical instruments, the artificial heart valve stent comprises a stent main body, a stent outflow section and a bending arm; the near end of the stent outflow section and the far end of the stent main body are integrally formed; the bent arm is arranged on the support body and extends in the circumferential direction of the support body, the bent arm is provided with a bent arm connecting end and a bent arm free end in the circumferential direction of the support body, the bent arm connecting end and the support body are fixedly connected or integrally formed, and the bent arm free end and the support body are spaced. The heart valve prosthesis prosthesis comprises an inner stent and an outer stent, and the inner stent or the outer stent is the heart valve prosthesis stent. According to the artificial valve, the risk of perivalvular leakage after the artificial valve is implanted in an interventional mitral valve replacement operation can be reduced.

The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.

A prosthetic heart valve for replacing a native valve includes a collapsible and expandable stent having a proximal end and a distal end, the stent being formed of a plurality of struts forming cells. A valve assembly is disposed within the stent, the valve assembly including a plurality of leaflets and a cuff. At least one runner is coupled to a cell and configured to transition from a first configuration to a second configuration when the stent moves from the collapsed condition to the expanded condition.

This application belongs to the field of medical devices, specifically relating to a valve prosthesis and its delivery system for preventing paravalvular leakage. It includes a leak-proof device and a stent. The stent includes a valve suture segment. The leak-proof device is connected to the proximal portion of the stent. The leak-proof device has an irregular structure and has a first form and a second form. When the leak-proof device is in the first form, it is offset from the valve suture segment in the axial direction. When the leak-proof device changes from the first form to the second form, it returns to the preset form along a preset path towards the distal end of the stent, and at least a portion of the leak-proof device overlaps with the valve suture segment in the axial direction. This invention achieves a significant reduction in tube diameter and can specifically adapt to the physiological structure of the autologous valve, allowing it to better fit the autologous valve annulus and atrial tissue, effectively preventing regurgitation.

The application relates to a paravalvular leakage plugging device applied to a prosthetic valve with an annular body, comprising biodegradable foam attached to at least a section of the outer periphery of the annular body, which is water-swellable and has a first degradation rate; and a film wrapping the biodegradable foam, which is configured as a porous film and has a second degradation rate; when the biodegradable foam swells upon contact with water, the film does not constrain the swelling of the biodegradable foam, and the first degradation rate is different from the second degradation rate. The paravalvular leakage plugging device adopts biodegradable foam to plug the leakage, compared with a traditional metal plugging device, does not cause damage to the heart tissue and the valve, reduces the risk of complications, and meanwhile, the biodegradable foam gradually degrades after completing plugging, so that no residues are left in the human body, further reducing the long-term risk.

The invention relates to the technical application field of transcatheter artificial heart valves, and discloses a transcatheter aortic valve integrated skirt which comprises a valve support, an inner skirt edge is arranged on the inner side of the valve support, an outer skirt edge is arranged on the outer side of the valve support, and the inner skirt edge and the outer skirt edge are manufactured through an integrated forming process. A plurality of protruding supporting bosses are arranged on the side, away from the outer skirt edge, of the inner skirt edge, a plurality of leakage-proof assemblies are arranged on the side, away from the inner skirt edge, of the outer skirt edge, and a plurality of fixing assemblies are arranged on the inner side and the outer side of the valve support. The integrated inner skirt edge and outer skirt edge are free of suture lines, the hidden danger of perivalvular leakage caused by suture gaps is fundamentally eliminated, skirt edge dislocation caused by manual operation errors is avoided, meanwhile, bulb-shaped hollowed-out grooves formed by the adjacent leakage-proof bosses form pocket-shaped spaces, trace blood breaking through attachment gaps can be actively intercepted, and the leakage-proof effect is achieved. And the use safety of the artificial valve is improved.

The invention provides a mitral valve forming ring. The mitral valve forming ring comprises an inner core, and the inner core is configured to be capable of being plastically deformed from a first form to a second form under the expansion action of external force and kept in the second form. Wherein the first form is a saddle-shaped non-circular closed form conforming to a native mitral valve annulus, and the second form is a closed form which is flatter and closer to a circle than the first form. The mitral valve forming ring creates conditions for follow-up valve-in-ring operation, plastically deforms from a first form and is kept in a flatter and approximately circular second form in a transcatheter balloon dilatation mode, and the mitral valve forming ring can be matched with a cylindrical valve frame of an artificial valve prosthesis. The mitral valve forming ring in the second form is used for stably positioning the artificial valve prosthesis, and the occurrence probability of perivalvular leakage is remarkably reduced.

The utility model provides an artificial valve anchoring device which comprises two clamping arms connected with each other and a carrying arm connected between the two clamping arms, and any clamping arm comprises a clamping part, an opening and closing part and a transition part which are connected with each other. The clamping parts on the two clamping arms are arranged in a crossed manner, so that a clamping space with an opening is formed between the two clamping parts; after the artificial valve anchoring device reaches a designated position and is released, in the valve expansion process, the intersection position of the clamping parts on the two clamping arms is changed so that the clamping space between the clamping parts can be reduced, and the native valve leaflet in the clamping space can be clamped. Under the condition that a valve smaller than a valve ring is selected, anchoring can still be well achieved, displacement of the valve is avoided, and the risk of perivalvular leakage can be effectively reduced by clamping reflux holes of adjacent valve leaflets through the artificial valve anchoring device.

The utility model discloses an aorta artificial heart valve, and belongs to the technical field of medical treatment. The support mainly comprises a support body, a bag and a plurality of thin-strip-shaped elastic supporting pieces, the support body is of a circular ring body structure when unfolded, the middle section of the support body is provided with a middle waist, and the elastic bag wraps the outer side of the middle waist, so that a bag cavity isolated from the outside is formed inside the bag and located outside the support body; the elastic supporting piece elastically abuts against the inner circumferential wall of the bag, when the pressure in the bag cavity is larger than the pressure of the external environment, the bag expands and deforms, and the elastic supporting piece pushes the bag in the radial direction of the support through elastic force. The aorta artificial heart valve provided by the utility model can solve the problems that the existing artificial heart valve cannot be tightly attached to the uneven or irregular lesion tissue structure at the calcified part of a patient; the complete anastomosis of the aorta artificial heart valve and the diseased tissue structure of a patient is difficult to ensure, so that perivalvular leakage is easy to generate.

Heart valve replacement often involves complications associated with paravalvular leaks. Vascular plug and occlusive devices, as well as heart valves particularly beneficial in treating the phenomenon of paravalvular leaks are described to address this issue.

A prosthetic mitral valve includes a stent frame and an anchor assembly coupled to and peripherally surrounding the stent frame. The anchor assembly includes atrial anchors on the inflow end, ventricular anchors on the outflow end, and a central waist portion disposed therebetween. The anchor assembly generally defines an hourglass shape wherein the atrial and ventricular anchors flare radially outward and the central waist portion has a relatively smaller diameter. The prosthetic valve may include a gasket disposed peripherally around the central waist portion to seal the space between the body of the valve and the native valve annulus to prevent paravalvular leakage without increasing the profile of the valve to allow for smooth insertion into and deployment from a delivery device. The prosthetic valve may alternatively include a sealing fabric surrounding the anchor assembly defining a radial protrusion around the central waist portion to seal the native annulus.

The present invention provides a prosthetic heart valve device with improved fit, apposition and / or paravalvular leakage mitigation. Thus, the prosthetic device comprises an anchoring structure for supporting prosthetic valve leaflets, wherein the anchoring structure comprises and / or is formed at least partially from a hydrophilic material designed to swell when contacted by the water solute in the patient's blood. Locating the hydrophilic material to provide swelling to improve the fit and / or apposition of the device to the patient's tissues results in, inter alia, improved paravalvular leakage mitigation. Some of the methods and mechanisms described herein may also be used to provide a seal against the septal hole created during transseptal delivery of the device.

A docking device to secure a prosthetic heart valve at a native heart valve includes a coil and a compressible plug. The coil includes multiple helical turns when in a deployed orientation. The compressible plug includes a scaffold formed from a shape-memory material. The compressible plug is configured to provide a liquid plugging function. The compressible plug is movable between a radially compressed state in a delivery orientation and a radially expanded state in the deployed orientation. The compressible plug is coupled to a helical turn of the coil by a tether. In the deployed orientation, the tether is configured to accommodate relative movement between the compressible plug and the helical turn of the coil within a predefined range that depends at least on the tether.

An annuloplasty ring includes an elastic elongated core having a first region and a second region, wherein the first region is more stretchable than the second region and is configured to be positioned at the commissure of a target native heart valve. The first and second regions enable the annuloplasty ring to both reconstruct the commissure of the leaflets of the diseased native heart valve and to establish a seal around the artificial heart to prevent paravalvular leakage after "annular valve in-circuit surgery".

This invention discloses a sealing skirt for a heart valve, a heart valve, and a method for its preparation. The sealing skirt is disposed circumferentially on the outside of the valve arch. The sealing skirt includes a sealing skirt body and at least one sealing portion surrounding the outside of the sealing skirt body. One edge of the sealing portion is sealed to the sealing skirt body circumferentially, and the other edge of the sealing portion is connected to the sealing skirt body at multiple spaced intervals along the circumferential direction of the sealing skirt. The resulting sealing portion has multiple pocket-shaped structures with openings facing the same side and arranged sequentially in the circumferential direction of the sealing skirt. These pocket-shaped structures can be expanded away from the valve arch by the action of regurgitated blood. In the event of regurgitation, the pocket-shaped structures can be expanded by the pressure of the regurgitated blood, resulting in a better sealing fit between the expanded pocket-shaped structures and the valve annulus, effectively solving the problem of paravalvular leakage.

Embodiments herein relate to cardiac stent-valves for transcatheter delivery. A cardiac stent-valve for transcatheter delivery is compressible to a compressed state for delivery and expandable to an expanded state for implantation. The stent-valve can include a stent with an axial inflow end and an axial outflow end, a plurality of leaflets arranged within the stent, and a structured sealing skirt for reduction or prevention of paravalvular leakage. The structured sealing skirt comprises one or more sealing formations arranged on a radially outer surface of the structured sealing skirt. At least in the expanded state, at least one of the one or more sealing formations is shaped and arranged such that, at each axial level of the structured sealing skirt covered by the one or more sealing formations. Other embodiments are also included herein.

The invention discloses a peripheral leakage prevention material, a peripheral leakage prevention device, a peripheral leakage prevention skirt edge, a mold, an artificial heart valve, an artificial implant and a related method. The artificial implant comprises a support and a radial deformable simple structure, and the support is provided with a through blood flow channel; each valve leaflet is provided with a fixed edge and a free edge which are opposite to each other, the fixed edges are fixed to the support, and the free edges are used for controlling the blood flow channel; the peripheral leakage prevention structure is arranged in the circumferential direction of the support, and the peripheral leakage prevention structure is a plugging assembly, at least one part of the plugging assembly protrudes (extends) to the support in the radial direction, and the plugging assembly is of a deformable structure; and / or the outer skirt edge wraps the periphery of the bracket. The perivalvular leakage prevention structure can enable the inflow end of the stent to form a self-adaptive plugging effect, and perivalvular leakage is reduced.