67 results about "Perivalvular Leak" patented technology

The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.

A method for implanting a prosthetic valve apparatus in a novel location which replaces the function of a native diseased valve. The prosthetic valve apparatus includes a one way valve and an expandable valve seating. anchoring and securing apparatus in a newly created orifice near or at the center of the anterior valve leaflet. The prosthetic valve apparatus also causes the sealing of the native valve and thus results in a solution for paravalvular leakage and regurgitation.

An atrioventricular valve stent for puncture placement and a conveying system thereof relate to the prosthesis capable of being placed in human body, and especially relate to a atrioventricular valve stent and a placement operation apparatus thereof; the atrioventricular valve stent comprises an expansible outer support, a valve and a plurality of fixed arms; an inverted hook portion of the fixed arm and the fixed arm can form a seesaw lever; a draw line pulls the inverted portion to drive the fixed arm to expand, thus hooking a bicuspid valve leaflet, and fixing the valve stent on an atrioventricular valve; an inter-valve anti-backflow edge corresponding to the valve leaflet boundary can seal the boundary slit so as to prevent valve peripheral backflow; the conveying system comprises an outer sheath canal, a core and a push rod, wherein the core head is connected with the head sheath canal; the valve stent front end is compressed in the head sheath canal, and the rear end is compressed in the outer sheath canal; the push rod can push the valve stent outside the outer sheath canal in a multi-stage section mode, and release the stent; the draw line connected with the valve stent is matched with the inter-valve anti-backflow edge; the valve stent is easy to place in, adjust and retrieve, convenient and safe in operation, high in succeed rate, and can effectively prevent valve peripheral leakage.

The present disclosure relates to valve replacement devices that are foldable for catheter- based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporates an appropriate leaflet system for reliable functioning in situ.

The invention discloses an involvement type prosthetic heart valve stent with barbs and a preparation method thereof, and belongs to the technical field of involvement type medical devices. The stent is an elastic stent which can stretch or retract in a radial direction, and comprises a tubular structural part and a skirt-shaped open structural part; the diameter of the skirt-shaped open structural part is greater than that of the tubular structural part; the tubular structural part and the skirt-shaped open structural part are coaxially and fixedly connected; barks are also arranged in the stent; the barbs extend from the tubular structural structure to the skirt-shaped open structural part and are tilted to the outer side of the stent. The stent can extend and retract in the radial direction so as to facilitate the mounting, the transporting and the releasing in involvement treatment; the stent structure is matched with the physiological structure of a natural valve, has a certain self-positioning function, and is convenient to position and release quickly and accurately; the barbs can penetrate into the tissues around the valve after the heart valve is planted into a specific position so as to achieve a positioning effect; displacement and perivalvular leakage are not easily caused after the valve is released.

A prosthetic mitral valve with a frame comprises at least one arm shaped to deploy among a region of chordae tendineae of the native mitral valve to deflect these chords in order to pull the native valve leaflets around the frame to avoid paravalvular leaks. The frame may be made from two parts that are connected by sutures. The prosthetic valve may be deployed by a catherer comprising a deployment clamp attached to the valve frame where the deployment clamp is actuable to induce rotation of the frame.

Apparatus and methods for occluding perivalvular leaks located around the periphery of implanted replacement valves. The apparatus and methods may include both distal and proximal covers adapted for placement over a perivalvular leak, with the covers retained in position by tension between the proximal and distal flanges. The distal and proximal covers may be capable of collapsing into a delivery configuration amenable for delivery to an internal body location through a lumen of a delivery catheter and a deployment configuration in which a flange of the cover extends radially outward such that the flange defines a first major surface facing the opposing cover.

An oval valve for use in transcutaneous aortic (TAVI) or mitral valve implantation or for direct access valve implantation. The oval leaflet frame or stent provides a better seal with the oval native annulus to reduce perivalvular leaks. The valve leaflets are a bileaflet configuration to provide improved leaflet coaptation independent of the amount of ovality of the native valve annulus. The bileaflet configuration is less dependent upon the diameter and perimeter of the native valve annulus and provides leaflet coaptation without intravalvular leakage.

The invention discloses an artificial heart valve prosthesis and an artificial heart valve stent. The artificial heart valve stent comprises an outer-layer bracket and an inner-layer bracket, whereinthe inner-layer bracket is fixedly connected with the outer-layer bracket, the outer-layer bracket is provided with an outer-layer inflow channel structure and an outer-layer outflow channel structure, the outer-layer inflow channel structure and the outer-layer outflow channel structure are axially connected, the inner-layer bracket is provided with an inner-layer inflow channel structure and aninner-layer outflow channel structure and is located on the inner side of the outer-layer bracket in the radial direction, the inner-layer inflow channel structure and the inner-layer outflow channelstructure are connected in the axial direction, and an anchoring structure is arranged on the outer side of the inner-layer bracket. According to the artificial heart valve prosthesis and the artificial heart valve stent, the inner-layer bracket bears the artificial valve leaflet, and is high in rigidity and small in diameter, so that the area of the artificial valve leaflet can be reduced, the height required by the opening and closing movement of the valve leaflet is reduced, and the service life of the valve leaflet is prolonged; the outer-layer bracket is weak in relative rigidity, large in diameter and capable of preventing perivalvular leakage; and the anchoring structure is connected with the inner-layer bracket, and the anchoring force for preventing the prosthetic valve from moving is mainly borne by the inner-layer bracket with high rigidity, so that the service life of the stent is prolonged.

The invention discloses an intrusive type heart valve prosthesis and a preparation method thereof, and belongs to the technical field of intrusive type medical apparatuses. The intrusive type heart valve prosthesis comprises an elastic bracket, a covering film and at least two valves, wherein the elastic bracket can extend and retract along the radial direction, the covering film is sewed onto the inner wall or the outer wall of the bracket, the valves are arranged in a cavity of the bracket, the lower edge of each valve is sewed onto the covering film, the adjacent sides of the two adjacent valves are mutually spliced, and the side edges of the valves are sewed onto the bracket. The intrusive type heart valve prosthesis has the advantages that the function of natural valves can be well replaced; by adopting the elastic bracket, the valve structure can be conveniently loaded into a conveying device, and can also be conveniently released to the target position to be tightly combined with the surrounding tissues of the target position; the bracket is coated by the covering film, so the surrounding leakage of the valves is effectively prevented; the bionic degree of the sewing structure of the valve and the covering film is high, the natural valves can be well simulated, and the function of the natural valves is replaced; the structure is stable and firm, the durability and firmness are realized, the elastic extending and retracting requirements in the loading and release processes can be met, and the damage is avoided.

The invention discloses a support for an involvement type artificial cardiac valve and a preparation method thereof and belongs to the technical field of involvement type medical apparatus and instruments. The support is an elastic support capable of extending and contracting in the radial direction, the support comprises a tubular structure part and a skirt-shaped opening structure part, the diameter of the skirt-shaped opening structure part is larger than that of the tubular structure part, and the tubular structure part and the skirt-shaped opening structure part are fixedly connected in a coaxial mode. Due to the fact that the support is capable of extending and contracting in the radial direction, so that the support is convenient to install, convey and release in the involvement treatment, the support and a natural valve are fitted with each other in physiologic structure, the support has a certain self-location function, the support is convenient to locate and release rapidly and accurately, and displacement and perivalvular leakage are not prone to occurring after releasing.

A prosthetic valve device that includes multiple layers and liners attached to various locations on the layers to prevent paravalvular leakage.

An expandable member that is configured to engage an interior region of a prosthetic valve and capable of transitioning from a pre-deployment configuration at a pre-deployment temperature, where the expandable member is capable of being positioned in the valve at an interior valve region when the valve is disposed in a cardiovascular structure, to a post-deployment configuration when the expandable member is subjected to cardiovascular tissue temperature, where an outer surface region of the valve proximate the interior valve region is placed in intimate contact with host cardiovascular tissue of the cardiovascular structure at a first position and seals perivalvular leaks present at the first cardiovascular structure position.

The invention discloses a conveying system for an involvement type artificial cardiac valve and belongs to the technical field of involvement type medical apparatus and instruments. The conveying system comprises the involvement type artificial cardiac valve and a conveying device thereof, the functions of a natural valve can be well replaced with the valve, the blood can be effectively prevented from backflow through the valve, an elastic support is adopted, the support is convenient to install into the conveying device and release to the objective position rapidly for being combined with tissues around the objective position tightly, a wrapping film is adopted to wrap the support so that the perivalvular leakage can be prevented effectively, the sutured structure of the combination between valve leaflets and the wrapping film is high in bionic degree, the natural valve can be well simulated, the functions of the natural valve can be replaced, the structure is stable, firm and durable, and the valve can adapt to the elastic stretching requirements in the installing and releasing process so that the valve can not be damaged; the conveying device is simple in structure, convenient to use and high in releasing success rate, the valve is applicable to conveying-releasing strategies of the involvement type artificial cardiac valve in various ways, and the involvement type artificial cardiac valve can be released rapidly and accurately.

A method for implanting a prosthetic valve apparatus in a novel location which replaces the function of a native diseased valve after an Alfieri procedure. The prosthetic valve apparatus includes a one way valve and an expandable valve seating. anchoring and securing apparatus in a newly created orifice near or at the center of the anterior valve leaflet. The prosthetic valve apparatus also causes the sealing of the native valve and thus results in a solution for paravalvular leakage and regurgitation.

The invention relates to an aortic valve stent. The aortic valve stent comprises a stent body and a prosthetic valve connected to the stent body, the stent body is of a double-layer stent body and specifically comprises a balloon expanding stent body and a self-expanding stent body, the prosthetic valve is connected to the self-expanding stent body, and after the stent body is conveyed, the self-expanding stent body is located on the inner periphery of the balloon expanding stent body and tightly abuts against the balloon expanding stent body to the outer periphery; the balloon expanding stent body tightly abuts against the aortic valve of the human body to the outer periphery, and an anchoring structure is formed between the balloon expanding stent body and the self-expanding stent body. According to the stent with the prosthetic valve, through the double-layer design, the full expansion and fixation of the aortic valve are ensued, the shape and area in the stent are ensured, and meanwhile, the compliance and support strength of the stent are ensured; the occurrence of perivalvular leakage and central regurgitation is reduced, the diameter of the sheath is not increased, and the risks of vascular complications are avoided.

The invention relates to an aorta valve stent conveying system which comprises a push release device for conveying an aorta valve stent. Particularly, the aorta valve stent conveying system further comprises a special-shaped balloon catheter arranged at the front end of the push release device, the special-shaped balloon catheter comprises a balloon, the balloon is provided with a cylindrical connecting portion and a balloon expanding portion communicated with the cylindrical connecting portion, and the cylindrical connecting portion is connected with the front end of the push release device; according to the design of the balloon, after expansion, a positioning face is formed in the side, close to the cylindrical connecting portion, of the balloon expanding portion, when the aorta valve stent conveying system is in use, the balloon expanding portion of the balloon is located inside a left ventricle outflow tract and tightly fits the bottom of the human aorta valve through the positioning face, and the effects of positioning and reducing and / or resisting valve leakage are achieved.

The invention discloses a conveying device which comprises a guide tube assembly and a control assembly, wherein the control assembly is arranged at the rear end of the guide tube assembly; the control assembly comprises a first control mechanism; the first control mechanism comprises a hollow shell and a limiting unit; the limiting unit comprises a limiting part and a hollow accommodation part; the accommodation part is arranged in the shell; an axial groove and a circumferential groove are formed in the outer surface of the accommodation part; the limiting part penetrates through the shell and is accommodated in the axial groove or the circumferential groove, and then the shell can be axially moved or circumferentially rotated; and the limiting part is further driven by the shell to moveaxially or rotate circumferentially. By adopting the conveying device and a conveying system disclosed by the invention, a first control part is arranged, and a connecting guide tube in the guide tube assembly connected with an implant can be directly controlled to be rapidly switched to circumferential movement from axial movement, so that accurate and reliable implant release positions can be achieved, the implant can be tightly adhered to tissue, and the risk of perivalvular leakage can be reduced.

The invention provides a transcatheter valve system. The transcatheter valve system includes a valve portion and a perivalvular leakage-proof portion independent of the valve portion. The valve portion includes a valve frame, valve leaflets, sealing skirts and sutures for suturing the valve leaflets, the valve frame and the sealing skirts together. The perivalvular leakage-proof portion is independent of the valve portion and includes a fixing portion and a sealing portion; the fixing portion is used for anchoring the perivalvular leakage-proof portion on a corresponding position of lesion in the valve; and the sealing portion is used for filling a gap due to the fact that the valve cannot be attached on a wall well after being implanted. In operation, the perivalvular leakage-proof portion is implanted in a human body, and then the valve portion is implanted in the human body; on a good-adherent part, the implanted valve can compact the sealing portion of the perivalvular leakage-proof portion; on a poor-adherent part, the sealing portion is not fully compressed, and can fill the corresponding gap. The transcatheter valve system can effectively reduce the conveying diameter, can effectively select different perivalvular leakage-proof portion designs according to the lesion characteristics of different implanting points, and can greatly lower the occurrence rate of perivalvular leakage after the transcatheter valve is implanted.

A collapsible and expandable prosthetic heart valve stent is provided and comprising an outer section, a valve support defining a flow channel therethrough, a transition section configured to smoothly transition the outer section to the valve support. The valve support is disposed within an interior defined by the outer section, with the inflow end of the valve support disposed inside the outer section's interior. In some cases, the outflow end of the valve support is at least partially defined by the transition section. The prosthetic leaflets are disposed on the inner surface of the valve support's flow channel and are located at or above the annulus of the heart chamber. A paravalvular leakage mitigation system is attached to the stent to mitigate retrograde blood flow and / or regurgitation.

The invention relates to a heart valve prosthesis and a heart valve prosthesis system. The heart valve prosthesis comprises a valve frame and at least one protruding structure, the protruding structure comprises a protruding part, the protruding part is arranged on the valve frame and protrudes towards the outer side of the valve frame, and the protruding part is constructed to be capable of forming wrinkles when being compressed in the radial direction. After the artificial heart valve is implanted into the human body, the protruding parts in the protruding structures make corresponding contact with the autologous valve ring, the protruding parts can be subjected to the radial compression effect of the autologous valve ring, wrinkles formed by the protruding parts make contact with the autologous valve ring, the number of contact points of the protruding parts and the inner wall of the autologous valve ring can be increased, the adherence can be improved, and the size of the gap formed between the protruding part and the autologous valve ring is reduced, the flow speed of blood flowing through the gap can be reduced, protein in the blood is deposited in the gap, thrombus is formed, the gap can be blocked, and then perivalvular leakage is prevented.

A device (100) for medically sealing a perivalvular leak associated with implanted valves includes a bioresorbable tissue infiltratable sheet (116) for insertion through a perivalvular leak. A filament (122) extending through the sheet (116) is also provided which when pulled causes the sheet (116) to gather around the filament (122) on either side of the perivalvular leak. The gathered position of the sheet (116) may be secured by a series of stops and / or use of a capping member (200).

The invention relates to the technical field of medical instruments, in particular to an invasive artificial heart valve. The artificial heart valve comprises a valve leaf, valve leaf traction cables,a valved stent and a stent fixing hook, wherein the valve leaf is a single-leaf valve; the upper part of the valved stent is connected with the valved leaf, the middle upper part of the valved stentis connected with the valve leaf through multiple valve leaf traction cables; stent support feet are arranged at the bottom of the valved stent; and the fixing hook is located at the upper part of thevalved stent. According to the artificial heart valve, perivalvular leakage can be better prevented through redundant covering of the valve leaf, and obstruction of the outflow tract of a left ventricle is avoided; and the whole stent can be better fixed through the fixing hook and the support feet.

The invention discloses a novel double-layer occluder which includes an occluder body. A fixer is arranged at the upper end of the occluder body, and a connector is arranged at the lower end of the occluder body. The occluder body is connected to an external conveying steel cable through the connector, the occluder body includes an outer layer and an inner layer which are composed of metal wires,one of the ends of the metal wires of the inner layer and the outer layer are respectively fixed to the fixer, and the other of the ends of the metal wires of the inner layer and the outer layer are respectively fixed to the connector. The novel double-layer occluder has the advantages of good stability, high anatomical adaptability, not prone to hemolysis, and low valve influence, and the closureof paravalvular leak, patent ductus arteriosus and ventricular septal defect by a transcatheter intervention method is completed; the radial support force is high; the instrument structure is compact, red blood cells are not prone to passing, and occluder-related hemolysis is not prone to causing; after the instrument is deformed and fixed, residual parts on and below the paravalvular leak are few, the device is not close to an artificial valve, and the opening and closing of the artificial valve are not prone to influencing; and the damage to an approach blood vessel is small, and blood vessel complications are fewer.

A transcatheter prosthesis includes a stent, a prosthetic valve component, and an anti-paravalvular leakage component. The anti-paravalvular leakage component is coupled to the stent and includes an inner skirt, an outer wrap, a cavity, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer wrap is disposed around an outer surface of the stent and has an inflow end coupled to the inflow end of the inner skirt and a downstream end. The cavity is formed between an outer surface of the inner skirt and an inner surface of the outer wrap. An opening is disposed between the inner skirt and the outer wrap. The one-way valve includes a flap at the opening configured to open to allow blood flow into the cavity but prevent blood flow out of the cavity.

A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.

The invention discloses a heart valve stent and a heart valve prosthesis. The heart valve stent comprises a stent main body, which comprises mutually connected grid structure units, wherein the stentmain body is divided into an inflow channel, a transition section and an outflow channel in the axial direction, the inflow channel, the transition section and the outflow channel are connected in sequence, the stent further comprises a limiting structure connected with the stent main body, and the limiting structure is distributed on the outflow channel or the transition section in the circumferential direction, and is provided with a first projection part for limiting the stent from moving from the inflow channel to the outflow channel. According to the invention, the limiting structure is arranged on the outflow channel of the stent, so that the stent can be prevented from moving towards the outflow channel under the scouring of blood flow; the inflow channel of the stent is arranged toadapt to the shape of the native tissue, and the outer skirt edge is arranged in the circumferential direction of the outer side of the inflow channel at the position attached to the native tissue, so that perivalvular leakage can be effectively prevented while the valve is prevented from moving towards the inflow channel; and the size of the inflow channel of the stent can be small so as to effectively prevent atrioventricular block, and the size of the outflow channel can be small so as to reduce the compression on the aorta.

The invention provides an implant conveying device and an implant conveying system. The implant conveying device comprises a conveying assembly, a first control bending pipe and a second control bending pipe. At least one part of the conveying assembly movably penetrates through the first control bending pipe in the axial direction of the first control bending pipe. The first control bending pipe and the conveying assembly movably penetrate through the second control bending pipe in the axial direction of the second control bending pipe and are used for extending out of the far end of the second control bending pipe; the first bending control pipe and the second bending control pipe are configured to control bending respectively; and the extension direction of the conveying assembly is changed along with the bending shapes of the first control bending pipe and the second control bending pipe. By means of the configuration, bending control is conducted on the bending control pipe in a segmented mode, large-angle bending control can be achieved, and the problems that an existing conveying device is difficult to control bending and small in bending control angle are solved. The implant can be safely and accurately released in a narrow space, and the problems of perivalvular leakage and the like in the operation process are reduced.

An expandable member that is configured to engage an interior region of a prosthetic valve and capable of transitioning from a pre-deployment configuration at a pre-deployment temperature, where the expandable member is capable of being positioned in the valve at an interior valve region when the valve is disposed in a cardiovascular structure, to a post-deployment configuration when the expandable member is subjected to cardiovascular tissue temperature, where an outer surface region of the valve proximate the interior valve region is placed in intimate contact with host cardiovascular tissue of the cardiovascular structure at a first position and seals perivalvular leaks present at the first cardiovascular structure position.