Fluidized sorting device for tiny solid particles and method thereof

Abstract

The invention relates to a fluidized sorting device for tiny solid particles and a fluidized sorting method for tiny solid particles. A sorting device provided by the invention comprises a sorting column (5), wherein the top part of the sorting column (5) is provided with a feeding inlet (6); a ventilating micro-hole membrane (9) is arranged on the inner-lower part of the sorting column (5); the bottom part of the sorting column (5) is provided with an air vent (7); the fluidized sorting device also comprises an isolating case (4) and collecting tanks (8); the sorting column (5) is mounted in a space formed by the isolating case (4) so as to eliminate interference from external airflow; the sorting column (5) also comprises a plurality of the collecting tanks (8) longitudinally arranged along the sorting column (5); the colleting tanks (8) are arranged in the sorting column (5) in a push-pull manner; and corresponding holes (11) and collecting tank grooves (12) are arranged on the collecting tanks (8) and correspond to cavity channels on the sorting column (5). According to advantages of the invention, medicine solid particles with different densities or particle sizes can be separated and collected effectively; in addition, the fluidized sorting device is characterized by simple structure, small volume, small fluidized air quantity and low energy consumption.

Description

technical field [0001] The present invention relates to a solid separation device and method, in particular, the present invention relates to a fluidized separation device and method for tiny solid particles. Background technique [0002] The active ingredients of drugs may have different crystal forms. Different crystal forms have different physical and chemical properties, which will lead to differences in drug solubility, resulting in differences in drug dissolution and bioavailability, affecting the absorption process of drugs in the body, and ultimately affecting drug efficacy. . However, every step of the current solid drug production process may lead to changes in the crystal form of the active ingredient, so the analysis of drug crystal forms is particularly important for drug quality control. [0003] At present, the analysis of drug crystal forms mostly adopts X-diffraction method. The X-diffraction method has very strict requirements on the particle size and con...

AI Technical Summary

Problems solved by technology

These traditional sorting equipment are not suitable for the pretreatment process of small-scale drug crystal form X-ray diffraction analysis; and the presence of media in the process is not conducive to the separation process to maintain the crystal form of the active ingredient of the drug

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