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Dual-detection biochemical sensing detector integrated with optofluidics

A detector and double-detection technology, applied in the field of plasma resonance double-detection biochemical sensor detector, to achieve the effects of improving efficiency, parallel detection, and convenient operation

Inactive Publication Date: 2012-09-19
MINZU UNIVERSITY OF CHINA
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Problems solved by technology

[0004] In order to solve the deficiencies in the traditional single testing technology LSPR or SERS technology, the local surface plasmon resonance LSRP technology, microfluidic technology and micro-nano processing technology are used to realize a high-sensitivity, label-free nano-array biochemical detector, and use LSPR Detect the binding process of biomolecules, and use SERS technology to determine the adsorbed molecules

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  • Dual-detection biochemical sensing detector integrated with optofluidics
  • Dual-detection biochemical sensing detector integrated with optofluidics
  • Dual-detection biochemical sensing detector integrated with optofluidics

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Embodiment Construction

[0031] Below in conjunction with the accompanying drawings, the specific embodiments of the present invention will be further described in detail through specific examples.

[0032] Such as figure 1 As shown, the dual-detection biochemical sensor detector of the present invention includes: a light source system 1, an optical path shaping system 2, a sensor chip 3, a three-dimensional control system 4, a surface-enhanced Raman SERS detection system 5, a localized surface plasmon resonance LSPR Detection system 6; and automatic sample feeding control system 7; wherein, the sensor chip 3 is installed on the three-dimensional control system 4; the automatic sample feeding control system 7 injects samples to the sensor chip 3; the light source system 1 provides a laser or white light source; The light path shaping system 2 is vertically incident on the sensor chip 3; the laser light reflected by the sensor chip 3 enters the SERS detection system 5, and performs corresponding SERS d...

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Abstract

The invention discloses a dual-detection biochemical sensing detector integrated with optofluidics. The dual-detection biochemical sensing detector comprises a light source system, a light path reshaping system, a sensing chip, a three-dimensional control system, a surface-enhanced Raman SERS (Surface Enhanced Raman Scattering) detection system, a local surface plasma resonance LSPR (Localised Surface Plasmon Resonance) detection system and an automatic sampling control system. According to the sensing chip disclosed by the invention, two optical detection means of the LSPR and SERS are simultaneously adopted and are combined with microfluidics to form a novel microfluidics optical sensing chip; the application of traditional LSPR or SERS is extended by the technology; the sensing chip based on a double plasma structure has great attraction for biochemistry detection based on a liquid sample; and the research and application of the microfluidics optical sensing system are accelerated. The sample is detected by using two complementary modes of the LSPR and SERS; and the combination of the LSPR and SERS analytic technologies on the same substrate is realized.

Description

technical field [0001] The invention belongs to the field of biochemical sensing and detection, and relates to a surface-enhanced Raman spectrum-localized surface plasmon resonance dual-detection biochemical sensing detector integrated with microfluidic optics. Background technique [0002] Microfluidic optical plasmonics is the integration of microfluidics, photonics and plasmas. It is a new research direction gradually formed in recent years. Optical plasmons will generate infinitely many new applications in the fields of biology, chemistry, biochemistry, medicine, engineering, etc. Plasmons have unique physical properties, localized nanoscale optical properties that enhance the interaction of light with matter with free electrons. One of the important applications is plasmon-based biosensors. It has a wide range of applications and clear industrialization prospects in the fields of medicine, hygiene, food, and environmental science. [0003] At present, microfluidic op...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658G01N21/554
Inventor 耿照新
Owner MINZU UNIVERSITY OF CHINA
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