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Geranium strictipes effective part preparation and medical use of geranium strictipes for preventing and curing colonitis

An effective part, the technology of Burnet burnet, applied in the field of medicine, can solve problems such as difficulty in timing, long-term administration according to the amount, stimulation and injury of gastric mucosa, etc., and achieve good results, clear industrialization prospects, and low sample loss.

Inactive Publication Date: 2012-09-26
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report specifically applied to the treatment of ulcerative colitis
In addition, due to the bitter taste of Geshanxiao, it is generally difficult for patients with chronic and refractory diseases such as ulcerative colitis who need to take medicine for a long time to take regular decocted medicines on time and in the right amount.
And Geshanxiao contains a lot of tannins, so it may cause new irritation and damage to the gastric mucosa while treating chronic diseases

Method used

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  • Geranium strictipes effective part preparation and medical use of geranium strictipes for preventing and curing colonitis
  • Geranium strictipes effective part preparation and medical use of geranium strictipes for preventing and curing colonitis
  • Geranium strictipes effective part preparation and medical use of geranium strictipes for preventing and curing colonitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Preparation of the effective part of Burnet burnet (sample I)

[0019] 1.1 Instruments and reagents:

[0020] The FD-1C-80 freeze dryer is a product of Beijing Boyikang Experimental Instrument Co., Ltd. The ultra-clean workbench adopts SW-CJ-2FD double-person single-sided clean workbench from Suzhou Purification Equipment Co., Ltd., and the water-proof constant temperature incubator is from Shanghai. The product of Yiheng Technology Co., Ltd., the sterilizing pot is YXQ-LS-50SII vertical pressure steam sterilizer of Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory, and the rotary evaporator (R-210) is the product of Buqi, Switzerland, and the desktop high-speed freezing The centrifuge (TL-16R type) is a product of Shanghai Centrifuge Machinery Research Institute, and the ultraviolet spectrophotometer (722 type) was purchased from Shanghai Third Analytical Instrument Factory. The ultraviolet spectrum was measured with a Shimadzu UV-240 ultraviol...

Embodiment 2

[0027] Example 2: Preparation of effective fraction of Burnet burnet (sample II)

[0028] 2.1 Instruments and reagents: Same as Example 1.

[0029] 2.2 Medicinal materials: the same as in Example 1.

[0030] 2.3 Preparation of ethanol extract of Burnet burnet:

[0031] Take 5 kg of Geshanxiao medicinal material (dried root of Burnet burnet), soak in 10,000 ml of 60% ethanol, heat to 60°C for extraction, and extract 3 times, each time for 4 hours, 6 hours, and 8 hours respectively. The extracts were combined and concentrated under reduced pressure to obtain 1.63 kg of ethanol extract of Burnet burnet (crude extract II), that is, 1 g of extract is equivalent to 3.06 g of crude drug.

[0032] 2.4 Preparation of the effective part extract of Burnet burnet:

[0033] Dissolve the crude extract II (500 g) prepared under 2.3 in 3750 ml of distilled water and ultrasonically dissolve it fully, then use 750 g of macroporous adsorption resin AB-8 to absorb and mix the sample, put it ...

Embodiment 3

[0034] Example 3: Effects of effective parts of Burnet burnet on occult blood in rats with ulcerative colitis induced by acetic acid

[0035] 3.1 Experimental materials:

[0036] 3.1.1 Animals: SD male rats, weighing 220-240 grams, certificate number: SCXK (Dian) 2005-0008, provided by the Experimental Animal Center of Kunming Medical College. Rat feed and litter were provided by the Animal Experiment Center of Dali University.

[0037] 3.1.2 Test drugs: crude extract I, namely the ethanol extract of Burnet burnet prepared in Example 1; sample I, the effective part of Burnet burnet prepared in Example 1. In the experiment, sulfasalazine (SASP, produced by Shanghai Xinyi Jiahua Pharmaceutical Co., Ltd., batch number: 100527) was used as the positive control substance. When using it, the yellow sugar coating was scraped off with a blade, and it turned yellowish brown. 0.5% CMC-Na is prepared into a suspension with a dosage of 300 mg / kg for subsequent use.

[0038] 3.1.3 Rea...

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Abstract

The invention relates to Geranium strictipes effective part preparation and medical use of the Geranium strictipes for preventing and curing colonitis. The extract of the Geranium strictipes effective part provided by the invention is refined from Yi nationality's medicine Geshanxiao through macroreticular resin. Geshanxiao is dried roots of geranium strictipes R. Knuth which belongs to geraniaceae geranium wilfordii. According to the invention, a rat acetic acid caused ulcerative colitis model is adopted for observing influences on relevant biochemical criterions of common clinical symptoms, pathomorphology and oxidative damage by the Geranium strictipes effective part. As shown in the experimental results, the Geranium strictipes effective part has certain therapeutical effect on the acetic acid caused ulcerative colitis rat model, and can ameliorate clinical symptoms thereof. Therefore, the Geranium strictipes effective part can be expected and applied in preparation of drugs capable of preventing and curing the ulcerative colitis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, the invention relates to an effective part of Burnet burnet and its preparation method and medicinal use. The effective part is prepared from Geshanxiao, a herbal medicine commonly used by Bai and Yi nationalities in Yunnan, through a modern extraction process, has obvious anti-ulcerative colitis effects, and can be used to prepare health products or medicines for preventing and treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific intestinal inflammatory disease of unknown etiology that mainly involves the rectum, colonic mucosa and submucosa. Chronic inflammation and ulceration of the colonic mucosa are the main pathological features. It is generally believed that the pathogenesis of UC is related to autoimmunity, infection, heredity, mental and environmental factors. At present, no specific treatment drugs and methods hav...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/04
Inventor 李辉洪小凤耿玲张娴文赵昱李凤贤施贵荣
Owner DALI UNIV
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