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Compound ketoconazole liquid shampoo

A compound ketoconazole and shampoo technology, which is applied in hair care, pharmaceutical formulations, cosmetics, etc., can solve problems such as dry hair, poor preparation stability, and unstable finished products, and achieve improved flexibility, good compatibility, The effect of good preparation stability

Inactive Publication Date: 2012-10-03
广西厚德大健康产业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But 2% ketoconazole lotion (Cera) is a single drug, and its anti-inflammatory and anti-allergic effects are slightly weak
Compound ketoconazole hair lotion is a compound preparation, which adds an anti-inflammatory and anti-allergic ingredient—clobetasol propionate, which has a better anti-inflammatory and antipruritic effect on the head. It has been produced by many manufacturers at present, but It has problems such as softness and conditioning during use, poor hair cleansing and hair care effects, dry hair after use, and poor stability of the preparation.
Since auxiliary materials such as surfactants, conditioning agents, antioxidants, and acidity regulators need to be added to the preparation, the addition of auxiliary materials can easily cause damage to the active ingredients and make the finished product unstable

Method used

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  • Compound ketoconazole liquid shampoo
  • Compound ketoconazole liquid shampoo
  • Compound ketoconazole liquid shampoo

Examples

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Embodiment

[0045] The following examples further describe and demonstrate embodiments within the scope of the present invention. These examples are illustrative only and do not limit the scope of the invention, since many variations thereof are possible without departing from the spirit and scope of the invention.

[0046] shampoo composition

[0047]

[0048]

[0049] Preparation

[0050] The shampoos of "Example 1" to "Example 9" described above can be prepared by any conventional method well known in the art. They can be suitably prepared as follows:

[0051] Under stirring, add ketoconazole, clobetasol propionate, surfactant, conditioner (except emulsified silicone oil) into water, and heat to about 85°C. The mixture was cooled to about 55°C. Menthol was added to the mixture with stirring at about 55°C. The mixture was cooled to about 45°C. The emulsified silicone oil and other components (if included) such as conditioners, preservatives, pH adjusters, chelating agents, a...

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PUM

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Abstract

The invention discloses compound ketoconazole liquid shampoo. The liquid shampoo is mainly used for treating scalp pityriasis (dandruff), seborrheic dermatitis and tinea versicolor. By the compound ketoconazole liquid shampoo, the technical problems of poor dissolvability, low stability and poor compatibility of excipients and main drugs in raw materials of the preparation are solved, and the compound ketoconazole liquid shampoo has good effects of softening, conditioning and cleaning hair.

Description

technical field [0001] The invention relates to a compound ketoconazole shampoo, in particular to a compound ketoconazole shampoo with antifungal, anti-inflammatory and anti-allergic functions. Background technique [0002] Scalp pityriasis (dandruff), seborrheic dermatitis and tinea versicolor are common and frequently-occurring diseases in dermatology. They can occur in all ages and are mainly caused by fungal infections. In recent years, due to the deterioration of the environment and the increasingly fierce social competition , and its incidence is on the rise. At present, antifungal drugs are mainly used to treat such diseases clinically, and ketoconazole, an imidazole broad-spectrum antifungal drug, is one of the representative drugs, and its curative effect is positive. Early stage people adopt ketoconazole ointment to treat this type of disease, and curative effect is good, but it is inconvenient to apply to head disease, easily pollutes hair, clothing, 2% ketoconaz...

Claims

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Application Information

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IPC IPC(8): A61K8/891A61K8/73A61K8/63A61K8/49A61K8/46A61K8/97A61Q5/02A61P31/10A61P17/00A61K8/92
Inventor 陈晓军阮碧芳李品黄园唐弟光莫少红卢孙威覃晓媚
Owner 广西厚德大健康产业股份有限公司
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