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Mecobalamin tablet and preparation method thereof

A technology for methylcobalamin tablets and methylcobalamin, which is used in pharmaceutical formulations, medical preparations containing active ingredients, metabolic diseases, etc., can solve problems such as difficulty and cannot completely avoid light, and achieves improvement of uniformity and package saving. The effect of coating time and high coating efficiency

Active Publication Date: 2014-02-05
HANGZHOU CONBA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It is pointed out in numerous documents that methylcobalamin is a substance that is easily decomposed when exposed to light. light
In addition, a new methylcobalamin sustained-release capsule and its preparation method (201010156241.7) also proposes to avoid light during the preparation of capsule particles, but it is also difficult

Method used

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  • Mecobalamin tablet and preparation method thereof
  • Mecobalamin tablet and preparation method thereof
  • Mecobalamin tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A kind of methylcobalamin tablet, take 1000 pieces, the distribution ratio of each component is by weight (g):

[0042]

[0043] The preparation method of above-mentioned methylcobalamin sheet, its step is as follows:

[0044] (1) Preparation of coating solution: According to the formula amount, weigh Opadry and dissolve it in pure water to prepare a 30% solution.

[0045] (2) Take it out, mix methylcobalamin and starch evenly in the fluidized bed according to the above ratio, turn on the red safety light source of the coating solution prepared in step (1), and spray it evenly on the Mix the powder surface to make white granules containing methylcobalamin. The temperature of the coating inlet air is controlled at 40°C±5°C, and the atomization pressure is 1.8~2pa;

[0046] (3) Weigh the tablet filling agent, disintegrant, glidant, lubricant and the coated granules containing methylcobalamin according to the prescription quantity and mix them uniformly in a mixer for...

Embodiment 2

[0049] A kind of methylcobalamin tablet, take 1000 pieces, the distribution ratio of each component is by weight (g):

[0050]

[0051] The preparation method of above-mentioned methylcobalamin sheet is with embodiment 1.

Embodiment 3

[0053] A kind of methylcobalamin tablet, take 1000 pieces, the distribution ratio of each component is by weight (g):

[0054]

[0055] The preparation method of above-mentioned methylcobalamin sheet is with embodiment 1.

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Abstract

The invention provides a mecobalamin tablet which has very low content of related substances and can simultaneously realize rapid disintegration. The mecobalamin tablet is prepared by mixing mecobalamin powder with a coating filling agent, then using an Opadry coating to prepare mecobalamin coated particles under the conditions of protecting from light, further adding pharmaceutically acceptable tablet excipients, and tabletting. According to the mecobalamin tablet provided by the invention, the process flow of mecobalamin which is very sensitive to light is improved from the way of firstly tabletting and then coating to the way of firstly coating and then tabletting.. Through an advanced powder coating technology, the treatment of protecting from the light is performed on the mecobalamin in the first process step to complete the protection of the mecobalamin so as to enable the follow-up process steps to get rid of the influence of a light source on the mecobalamin, the means of controlling the related substances is better than the traditional full-process operation of protecting from the light, the coating time is saved, and the efficiency is improved.

Description

(1) Technical field [0001] The invention relates to a methylcobalamin tablet and a preparation method thereof, in particular to a preparation method capable of effectively controlling the content of related substances in the methylcobalamin tablet and reducing production man-hours and energy consumption. (2) Background technology [0002] Methylcobalamin is a kind of vitamin B12, its structure is a macrocyclic complex centered on cobalt ion, [0003] The relationship between vitamin B12 and methylcobalamin is: methylcobalamin is a kind of vitamin B12. There are many forms of vitamin B12, the common ones are cyanocobalamin, methylcobalamin, adenosylcobalamin and hydroxocobalamin; among them, methylcobalamin and adenosylcobalamin are coenzyme vitamin B12, and only these two kinds of vitamin B12 can To be used directly by the body, other vitamin B12 needs to be converted into these two forms within the cells in order to be utilized. [0004] Adenosylcobalamin is a kind of vit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K31/714A61K47/36A61K47/38A61P3/02
Inventor 徐春玲金朱明徐秀卉陆振宇黄海波徐鹏鹤
Owner HANGZHOU CONBA PHARMA
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