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Novel preparation technology of rabdosia rubescens tablet

The invention relates to a technology of Rubescensica and a new process, which is applied in the field of new technology for the preparation of Rubescens rubescens tablets, and can solve the problems of unstable diterpenoid components when exposed to heat, unstable drug quality, influence on clinical efficacy and the like, so as to reduce the preparation time. , low cost, good therapeutic effect

Active Publication Date: 2012-10-31
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Oridonin, the main component of Rubescens, is unstable to heat, and the diterpenoid components such as oridonin decline rapidly during the preparation and storage process, resulting in unstable drug quality and affecting clinical efficacy
The shortcoming of above-mentioned two kinds of techniques is: 1, ethanol extraction heating time is long, and diterpene components such as oridonin A are unstable when heated, and content declines rapidly in the extraction process
4. The whole process of extraction, concentration, granulation, drying and tableting consumes a lot of energy

Method used

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  • Novel preparation technology of rabdosia rubescens tablet
  • Novel preparation technology of rabdosia rubescens tablet
  • Novel preparation technology of rabdosia rubescens tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take 3,000 grams of Oryx japonicus and cut them into 0.5 cm long sections, use a flash extractor (patent number ZL200520031604.9 product) to extract once, add 5 times (volume / weight times, ie ml / g, the same as in the following examples) Extract with 50% ethanol at room temperature for 1 minute, filter the extract, and combine the filtrate; the filtrate is concentrated under reduced pressure (vacuum degree 0.01 Mpa) to recover ethanol and concentrate to a clear paste with a relative density of 1.25 (60°C), and add 1 weight times β to the clear paste -Cyclodextrin is made into clathrate by grinding method; add auxiliary material starch, mix well, make granules, dry (temperature 50℃, vacuum degree 0.10 Mpa), press into 1000 tablets, and coat with sugar.

Embodiment 2

[0038] Take 3000 grams of Cordyceps japonicus and cut them into 2.0 cm long sections, extract 3 times with a flash extractor (patent number ZL200520031604.9 product), add 20 times 95% ethanol for 30 minutes at room temperature each time, filter the extract, and combine the filtrates ; The filtrate is concentrated under reduced pressure (vacuum degree 0.10 Mpa) to reclaim ethanol and concentrate to a clear paste (50° C.) with a relative density of 1.30. The clear paste is added with 15 times by weight of β-cyclodextrin by grinding to make an inclusion complex; The auxiliary material starch is mixed evenly, made into granules, dried (temperature 70°C, vacuum degree 0.01Mpa), pressed into 1000 tablets, and coated with sugar.

Embodiment 3

[0040]Take 3000 grams of Cordyceps japonicus and cut them into 1.0 cm long sections, extract twice with a flash extractor (patent number ZL200520031604.9 product), add 15 times of 80% ethanol for 10 minutes at room temperature each time, filter the extract, and combine the filtrate ; The filtrate is concentrated under reduced pressure (vacuum degree 0.05Mpa) to recover ethanol and concentrate to a clear paste with a relative density of 1.25 (60°C). The clear paste is added with 6 times the weight of β-cyclodextrin by grinding to make an inclusion complex; The auxiliary material starch is mixed evenly, made into granules, dried (temperature 60°C, vacuum degree 0.05 Mpa), pressed into 1000 tablets, and coated with sugar.

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Abstract

The invention belongs to the field of the production and storage of Chinese patent medicine, and particularly discloses a novel preparation technology of rabdosia rubescens tablet. The technology comprises the following steps of: cutting the rabdosia rubescens into sections or grinding into coarse powder; adding ethanol and extracting for 1 minute to 4 hours; filtering the extraction liquid; collecting the filtrate; adding beta-cyclodextrin which is 1-15 times by weight as much as the filtrate into the filtrate and preparing into an inclusion compound by the cyclodextrin inclusion technology; drying; adding accessories and mixing uniformly; and granulating and tabletting to obtain the rabdosia rubescens tablet, wherein the extraction mode is CO2 supercritical extraction. The terpene components such as oridonin are unstable when heated. The extraction method disclosed by the invention can completely extract the active ingredients and can reduce or avoid the use of heat sources; and through the supermolecular technology and the barrel structure of beta-cyclodextrin, the terpene components such as oridonin can form a supermolecule body (inclusion compound) through hydrogen bond, Van der Waals' force and the like, and the damage to the terpene components such as oridonin is avoided.

Description

technical field [0001] The invention belongs to the field of production and storage of Chinese patent medicines, in particular to a new process for preparing Donglingcao tablets. Background technique [0002] Donglingcao is the dry above-ground part of Rabdosia Rubescens (Hemsl.) Hara of the Lamiaceae family. It is harvested and sun-dried in summer and autumn when the stems and leaves are flourishing. It is a herbaceous plant for many years. After the frost, the whole body is covered with silver-white icicles as thin as cicada's wings, so it is also called ice flower, ice grass, and ice water plant. Donglingcao is slightly cold in nature, bitter and sweet in taste, and returns to the lung, stomach and liver meridians, and can clear away heat and detoxify, promote blood circulation and relieve pain. The main components of Oridonin are Oridonin A, B, C, Dingin, rosmarinic acid, etc. Oridonin A is a compound with significant anticancer activity. [0003] Donglingcao Tablet ha...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/20A61P1/02A61P11/04
Inventor 李钦张瑜陈振中张昀
Owner HENAN UNIVERSITY
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