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L-tryptophan molecular imprinted TiO2 powder and preparation method thereof

Inactive Publication Date: 2014-05-21
CHANGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it is a thin film material, there are also disadvantages such as small adsorption capacity and easy peeling off of the film.

Method used

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  • L-tryptophan molecular imprinted TiO2 powder and preparation method thereof
  • L-tryptophan molecular imprinted TiO2 powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) TiO imprinted with L-tryptophan template molecules 2 Sol preparation

[0024] Weigh 1.28g of L-tryptophan and 85.0g of tetra-n-butyl titanate into 500mL of absolute ethanol, stir to dissolve all the solids, and continue stirring for 24 hours to fully combine the amino acid with tetra-n-butyl titanate to obtain imprinted L - TiO of tryptophan template molecule 2 Sol;

[0025] (2) TiO imprinted with L-tryptophan template molecules 2 Powder preparation

[0026] The TiO imprinted with L-tryptophan template molecules obtained in step (1) 2 The sol was mixed and stirred for 24 hours according to the ratio of the mass ratio of titanium alkoxylate compound to water of 1:5.88, and the obtained white precipitate was filtered by suction and dried to obtain TiO2 imprinted with L-tryptophan molecules. 2 Powder;

[0027] (3) Removal of L-tryptophan template molecule

[0028] The TiO imprinted with L-tryptophan molecules obtained in step (2) 2 The powder is eluted with an ...

Embodiment 2

[0032] The amount of L-tryptophan added in Example 1 was changed to 2.55g, and the rest of the conditions were the same as in Example 1. Determination of TiO with L-tryptophan molecular imprinting prepared in this example 2 The adsorption capacity of the powder to L-tryptophan was 3.06 mg / g, the adsorption capacity to D-tryptophan was 1.89 mg / g, and the selective separation coefficient α was 1.62, as shown in Table 1.

Embodiment 3

[0034] The amount of L-tryptophan added in Example 1 was changed to 5.10 g, and all the other conditions were the same as in Example 1. Determination of TiO with L-tryptophan molecular imprinting prepared in this example 2 The adsorption capacity of the powder to L-tryptophan is 2.90 mg / g, the adsorption capacity to D-tryptophan is 1.60 mg / g, and the selective separation coefficient α is 1.82, as shown in Table 1.

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Abstract

The invention relates to an L-tryptophan molecular imprinted TiO2 powder and a preparation method thereof. The preparation method thereof comprises the following steps of: taking titanic alcoxyl compound as a sol precursor and alcohol as a solvent; preparing TiO2 sol imprinted with L-tryptophan template molecules by adopting a sol-gel method; hydrolyzing the sol; leaching; drying to obtain the TiO2 powder imprinted with L-tryptophan template molecules; and finally, adding ammonia water to wash the powder, removing L-tryptophan template molecules, and thus obtaining the powder. The powder can be used for directly separating a tryptophan optical isomer in a water phase, and racemic tryptophan can be effectively separated.

Description

technical field [0001] The invention relates to the field of molecularly imprinted sol-gel materials, in particular to a kind of L-tryptophan molecularly imprinted TiO 2 Powder and its preparation method. Background technique [0002] Tryptophan is an essential amino acid that constitutes protein molecules, and it has two optical isomers. L-tryptophan is an essential amino acid for the human body, which is involved in human protein synthesis and metabolic network regulation, while D-tryptophan mainly exists in microorganisms and green plants, and its content is less in animals, and it hardly undergoes metabolism in the human body . The use of L-tryptophan as a treatment for pellagra, schizophrenia, nutritional medicines, and essential amino acid tablets has been widely recognized, while D-tryptophan has different medicinal values. Therefore, splitting the optical isomers of tryptophan is of great significance in the fields of medicine, food, hygiene and so on. [0003] M...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/29C01G23/053B01J20/06B01J20/30C07D209/20
Inventor 陈智栋何莹张静申屠超王文昌
Owner CHANGZHOU UNIV