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Hydroxyapatite hollow microsphere and preparation method thereof

A hydroxyapatite, hollow microsphere technology, applied in chemical instruments and methods, phosphorus compounds, nanotechnology for materials and surface science, etc., to achieve the effects of controllable size, convenient operation and good application prospects

Active Publication Date: 2012-12-05
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the research on the preparation of hydroxyapatite hollow microspheres is active at present, there is no simple and low-cost suitable method to control the diameter of hydroxyapatite hollow spheres and the size of the cavity.

Method used

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  • Hydroxyapatite hollow microsphere and preparation method thereof
  • Hydroxyapatite hollow microsphere and preparation method thereof
  • Hydroxyapatite hollow microsphere and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] At room temperature, 1.791 g of Na 2 HPO 4 12H 2 O was dissolved in 250 ml of deionized water to form solution A, and 1.762 g of Ca(CH 3 COO) 2 ·H 2 O was dissolved in 100 mL of deionized water to form solution B. Add 0.020 g of protidine DNA to 60 ml of solution A, stir at room temperature to dissolve it completely, adjust the pH to 5 with 1 mol / liter of hydrochloric acid, then add 20 ml of solution B dropwise, and use 1 mol / liter of solution B in the process. liters of hydrochloric acid to adjust the pH to maintain it at around pH 5. After the addition is complete, transfer the mixed clear liquid into a Teflon liner (liner capacity 100 ml) and seal. Put the lining into the hydrothermal reaction jacket and put it into the holding furnace together with the jacket, and keep it warm at 150°C for 12 hours. After the reaction system was naturally cooled to room temperature, the product was taken out, and the product was separated by centrifugation. The separated prod...

Embodiment 2

[0047] At room temperature, 1.791 g of Na 2 HPO 4 12H 2 O was dissolved in 250 ml of deionized water to form solution A, and 1.762 g of Ca(CH 3 COO) 2 ·H 2 O was dissolved in 100 mL of deionized water to form solution B. Take 0.060 g of protidine DNA and add it to 60 ml of solution A, stir at room temperature to dissolve it completely, adjust the pH to 5 with 1 mol / liter of hydrochloric acid, then add 20 ml of solution B dropwise, and use 1 mol / liter of solution B in the process. liters of hydrochloric acid to adjust the pH to maintain it at around pH 5. After the addition is complete, transfer the mixed clear liquid into a Teflon liner (liner capacity 100 ml) and seal. Put the lining into the hydrothermal reaction jacket and put it into the holding furnace together with the jacket, and keep it warm at 150°C for 12 hours. After the reaction system was naturally cooled to room temperature, the product was taken out, and the product was separated by centrifugation. The se...

Embodiment 3

[0051] At room temperature, 1.791 g of Na 2 HPO 4 12H 2 O was dissolved in 250 ml of deionized water to form solution A, and 1.762 g of Ca(CH 3 COO) 2 ·H 2 O was dissolved in 100 mL of deionized water to form solution B. Add 0.100 g of protidine DNA to 60 ml of solution A, stir at room temperature to dissolve it completely, adjust the pH to 5 with 1 mol / L of hydrochloric acid, then add 20 ml of solution B dropwise, and use 1 mol / L of liters of hydrochloric acid to adjust the pH to maintain it at around pH 5. After the addition is complete, transfer the mixed clear liquid into a Teflon liner (liner capacity 100 ml) and seal. Put the lining into the hydrothermal reaction jacket and put it into the holding furnace together with the jacket, and keep it warm at 150°C for 12 hours. After the reaction system was naturally cooled to room temperature, the product was taken out, and the product was separated by centrifugation. The separated product was washed three times with dei...

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Abstract

The invention relates to a hydroxyapatite hollow microsphere and a preparation method thereof. The hydroxyapatite hollow microsphere is prepared by using water-soluble calcium salt and phosphate as raw materials, water as a solvent and DNA as a template agent through hydrothermal reaction. The diameter of the hydroxyapatite hollow microsphere and the size of the cavity can be effectively adjusted by changing the adding amount of the DNA.

Description

technical field [0001] The invention relates to a hydroxyapatite hollow microsphere and a preparation method thereof. It specifically relates to a method for assisting the preparation of hydroxyapatite hollow microspheres by using DNA as a template agent, and belongs to the field of biological material preparation. Background technique [0002] Hydroxyapatite has inorganic components similar to human bones and teeth. The calcium and phosphorus contained in it are essential nutrients for cell growth. Its good biological activity, biocompatibility and biodegradability make it often used in It is used in biomedical fields such as bone substitute materials, drug delivery carriers, and gene transfection. [0003] Due to different synthesis methods, hydroxyapatite has different crystallinity, size, morphology and physical and chemical properties, so it has different uses. Currently, various methods have been applied to prepare HA nanostructures with different morphologies. For ...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
Inventor 朱英杰漆超陈峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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