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Chinese herbal composition and extract used for treating depression and preparation method and application thereof

A depression and composition technology, applied in the field of traditional Chinese medicine compositions for the treatment of depression, can solve the problems of high safety level requirements in production workshops, adverse solvent reactions, difficult quality control, etc., so as to reduce the incidence of adverse reactions and avoid treatment. The effect of narrow spectrum and reduced dosage of medicinal materials

Inactive Publication Date: 2012-12-12
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, solvent extraction is easy to pollute the environment, and the safety level of the production workshop is high, and there is a possibility of adverse reactions caused by solvent residues
In addition, the original prescription of Xiaoyao San has more medicinal materials, and the dosage is relatively large, so the quality is not easy to control

Method used

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  • Chinese herbal composition and extract used for treating depression and preparation method and application thereof
  • Chinese herbal composition and extract used for treating depression and preparation method and application thereof
  • Chinese herbal composition and extract used for treating depression and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 120g of Bupleurum bupleuri, 120g of angelica, 120g of fried Atractylodes macrocephala, 60g of roasted licorice, 40g of mint and 40g of dried ginger, mix them evenly, grind them into fine powder, and put them into supercritical CO 2 In the extraction device, the set process parameters are: extraction pressure 20MPa, extraction temperature 50°C, CO 2 Flow 25kg·h -1 , The extraction time was 3.0h, and the extracted product was collected, that is, the product yield was 1.70%.

Embodiment 2

[0024] Weigh 80g of Bupleurum bupleuri, 160g of angelica, 240g of fried Atractylodes macrocephala, 40g of roasted licorice, 32g of mint and 80g of dried ginger, mix them evenly, grind them into fine powder, and put them into supercritical CO 2 In the extraction device, the set process parameters are: extraction pressure 20MPa, extraction temperature 50°C, CO 2 Flow 25kg·h -1 , The extraction time was 3.0h, and the extracted product was collected, that is, the product yield was 1.65%.

Embodiment 3

[0026] Weigh 160g of Bupleurum bupleuri, 200g of angelica, 200g of fried Atractylodes macrocephala, 120g of roasted licorice, 80g of mint and 80g of dried ginger, mix them evenly, grind them into fine powder, and put them into supercritical CO 2 In the extraction device, the set process parameters are: extraction pressure 20MPa, extraction temperature 50°C, CO 2 Flow 25kg·h -1 , The extraction time was 3.0h, and the extracted product was collected, that is, the product yield was 1.68%.

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Abstract

The invention discloses a Chinese herbal composition and extract used for treating depression and a preparation method and an application thereof. The Chinese herbal composition is composed of bupleurum, Chinese angelica, fried white atractylodes rhizome, honey-fried licorice root, mint and dried ginger, thus a formula is simpler. The preparation method of the Chinese herbal composition comprises the steps of weighing the Chinese herbal medicines in proportion, smashing the Chinese herbal medicines, placing the smashed Chinese herbal medicines into a CO2 extraction kettle, controlling parameters such as pressure, temperature, CO2 flow and extraction time and obtaining the extract. Pharmacodynamic test results show that the extract can obviously reduce dead time in a mouse forced swinging test and a mouse tail suspending test, which proves that the extract disclosed by the invention has obvious anti-depression effect, anti-depression activity reaches up to or is higher than those of anti-depression western medicines which are frequently used in clinical application and the traditional anti-depression Chinese herbal medicine compound Xiaoyao powder. And the extract is prepared by adopting an advanced and non-toxic supercritical CO2 extraction process without pollution or solvent residue, thus safety is better, and the extract disclosed by the invention is an ideal anti-depression medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating depression, an extract and a preparation method and application thereof. Background technique [0002] Depression is a common mental illness, characterized by high incidence, high recurrence rate, and high disability rate. The incidence rate in my country is 2.5%, and the number of patients exceeds 30 million. Severe cases have suicidal tendencies. However, the current drugs for the treatment of depression are not ideal, mainly based on chemical drug therapy, such as tricyclics (imipramine, amitriptyline, etc.), monoamine oxidase inhibitors (phenelzine, moclobemide, etc.) , selective 5-HT reuptake inhibitors (fluoxetine, paroxetine, sertraline, venlafaxine, etc.), but these chemical drugs have problems such as narrow therapeutic spectrum, poor tolerance, large toxic and side effects, and high price . [0003] I...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P25/24
Inventor 田俊生秦雪梅张丽增郭晓擎高晓霞周玉枝
Owner SHANXI UNIV
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