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Preparation technology and production method for integrated new formulation of radix bupleuri, cassia twig and dry ginger decoction

A kind of Guizhigan and integrated technology, which is applied in the field of preparation of new integrated dosage forms of Chaihu Guizhi Ganjiang Decoction, can solve the problems of ineffective effect and the like, and achieves the effects of strong sustained and controlled release performance and wide target distribution.

Inactive Publication Date: 2013-01-30
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking countless medicines with no effect

Method used

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Examples

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Effect test

preparation example Construction

[0042] The preparation production method of the present invention comprises the following steps:

[0043]Firstly, take each Chinese herbal decoction piece for pretreatment, weigh it, put it into a pulverizer and pulverize it to 80-200 mesh, and then use a supersonic airflow to pulverize it to 1-10 microns to obtain micron powders of different Chinese medicines for future use. Take 60% Bupleurum, Guizhi, Dried Ginger, and Trichosanthes root micron powder with 6-12 times the amount of 30%--90% alcohol aqueous solution, mix and soak for 1-2 days, reflux extraction 3 times, extract water-soluble, alcohol Soluble and ester-soluble three effective drug ingredients, recover alcohol, and obtain extracts for future use. Take 60% of Scutellaria baicalensis, oysters, and roasted licorice micron powder, and use ultrasonic dispersion extraction equipment to disperse and extract them respectively. spare. The traditional Chinese medicine extract obtained above is ground by a nano ball mill...

Embodiment 1

[0045] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0046] The raw materials for making active ingredients are as follows: 8 parts of bupleurum, 3 parts of cassia twig, 2 parts of dried ginger, 4 parts of Trichosanthes root, 3 parts of scutellaria baicalensis, 2 parts of oyster and 2 parts of roasted licorice.

[0047] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to...

Embodiment 2

[0049] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0050] The raw materials for making active ingredients are as follows: 8 parts of bupleurum, 3 parts of cassia twig, 2 parts of dried ginger, 4 parts of Trichosanthes root, 3 parts of scutellaria baicalensis, 2 parts of oyster and 2 parts of roasted licorice.

[0051] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels,...

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Abstract

The present invention relates to a preparation technology and a production method for an integrated new formulation of a radix bupleuri, cassia twig and dry ginger decoction, wherein the raw materials of active ingredients comprise: 8 parts by weight of radix bupleuri, 3 parts by weight of cassia twig, 2 parts by weight of dry ginger,4 parts by weight of snakegourd root, 3 parts by weight of radix scutellariae, 2 parts by weight of oyster, and 2 parts by weight of honey-fried licorice root. The production process of the integrated new formulation comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of radix bupleuri, cassia twig and dry ginger decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of radix bupleuri, cassia twig and dry ginger decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of radix bupleuri, cassia twig and dry ginger decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

Description

technical field [0001] The invention relates to a new integrated dosage form of Bupleurum Guizhiganjiang Decoction, and also relates to a preparation technology for the integrated new dosage form of Bupleurum Guizhiganjiang Decoction. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reduction and other rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/00A61P33/06A61P1/16A61P9/06A61P9/10A61P15/00A61P15/12A61P15/14A61P17/10A61P1/02A61P17/02A61P27/02
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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