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Tissue engineering controllable hydraulic bioreactor

A technology of bioreactor and tissue engineering, which is applied in the direction of special-purpose bioreactor/fermenter, tissue cell/virus culture device, biochemical instrument, etc., which can solve the problem of single direction of force application and lack of corresponding support on the non-stressed surface of cartilage. Mechanical stimulation, uneven mechanical properties of cartilage, etc., to reduce the possibility and simplify the complexity

Active Publication Date: 2014-12-03
湖南中科要素生物科技有限公司
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Problems solved by technology

However, these two reactors are mainly based on the unequal pressure application mode, because the single direction of the force application will lead to the lack of corresponding mechanical stimulation on the non-stressed surface of the cartilage, which will cause inhomogeneous mechanical properties of the cartilage constructed in vitro and fail to achieve a large volume. , special shape of cartilage (such as auricular cartilage) for mechanical properties and precise shape requirements

Method used

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  • Tissue engineering controllable hydraulic bioreactor

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Embodiment

[0024] like figure 1 As shown, a controllable hydraulic bioreactor for tissue engineering includes a tank body 1, a top cover 2 is arranged on the tank body 1, and a controllable hydraulic system is arranged on the upper end of the top cover 2, and the tank body 1 is provided with a controllable hydraulic system. The lower part of the body 1 is provided with a circulation perfusion system. Cultures housed in tanks are provided with the required hydraulic stimulation by a controllable hydraulic system during pressurized stimulation. During cultivation, a recirculating perfusion system supplies the culture with fresh medium and exchanges out old medium.

[0025] A flexible diaphragm 16 is arranged inside the tank body 1 , and the flexible diaphragm 16 separates the chamber formed by the tank body 1 and the top cover 2 into a culture chamber 17 and a pressurized chamber 18 . The flexible diaphragm 16 can also be replaced by other separators with the same function, so any replac...

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Abstract

Disclosed in the present invention is a controllable hydraulic bioreactor used in tissue engineering, which includes a tank-body and a head cover. A controllable hydraulic system is provided at the upper part of the head cover; a circulation perfusion system is provided at the lower part of the tank body; a flexible membrane is provided in the tank body, and the flexible membrane divides the cavity formed by the tank body and the head cover into a culturing cavity and a pressuring cavity; a porous barrier is provided at the lower part of the culturing cavity.

Description

technical field [0001] The invention relates to a tissue engineering bioreactor, in particular to a controllable hydraulic bioreactor for tissue engineering with an independent pressurized cavity. Background technique [0002] Ear defects caused by congenital microtia, trauma and other factors are very common in plastic surgery, but the repair of autologous bone carving is traumatic, and the use of tissue engineering methods to construct cartilage with precise auricle shape in vitro will become the best choice for repairing ear defects. Important new medical solutions. However, the mechanical properties of the human auricle cartilage constructed in vitro are poor, and the clinical requirements for reconstructing the morphological stability of the auricle cannot be met after being implanted into the subcutaneous tissue. Therefore, it is necessary to improve the mechanical properties of engineered cartilage when constructed in vitro. [0003] Mechanical stimulation can signi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00
CPCC12M3/00C12M35/04C12M21/08
Inventor 刘海蓉戴瑶周征夏磊磊周广东
Owner 湖南中科要素生物科技有限公司
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