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Compound sustained-release capsule containing ibuprofen and pseudo ephedrine

A technology of sustained-release capsules and pseudoephedrine, which is applied in the field of medicine and can solve the problems of affecting integrity and high initial release of pseudoephedrine

Inactive Publication Date: 2013-02-13
SINO AMERICAN TIANJIN SMITHKLINE & FRENCH LAB +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Deformed and viscous ibuprofen pellets affect the integrity of the functional coating of pseudoephedrine sustained-release pellets, resulting in higher initial release of pseudoephedrine in compound sustained-release capsules

Method used

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  • Compound sustained-release capsule containing ibuprofen and pseudo ephedrine
  • Compound sustained-release capsule containing ibuprofen and pseudo ephedrine
  • Compound sustained-release capsule containing ibuprofen and pseudo ephedrine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Preparation of pseudoephedrine sustained-release pellets

[0053] Weigh each ingredient in the pseudoephedrine hydrochloride sustained-release (PSE SR) pellet formulation shown in Table 1.

[0054] Table 1. The formula of PSE SR pellets

[0055]

[0056] Spray the pseudoephedrine hydrochloride solution layer by layer on the surface of the NPS in a fluidized bed to form pseudoephedrine drug-loaded pellets. Subsequently, HPMC solution (10% w / w) was sprayed onto the surface of pseudoephedrine hydrochloride drug-loaded pellets to form pseudoephedrine hydrochloride drug-loaded closed coating (DLSC) pellets.

[0057] In a fluidized bed, an aqueous dispersion of ethyl cellulose (15% w / w) was sprayed onto the surface of the pseudoephedrine DLSC pellets to form a sustained release layer. Then spray the Opadry pink dispersion on the surface of the sustained-release layer to form a colored coat layer. The obtained pellets were cured for about 1 hour under high temperature co...

Embodiment 2

[0058] Example 2: Preparation of ibuprofen sustained-release pellets

[0059] Weigh each ingredient in the ibuprofen sustained release (IBU SR) pellet formulation shown in Table 2.

[0060] Table 2. The formula of ibuprofen sustained-release pellets

[0061]

[0062] Spray an ethanol solution of stearic acid (4.5% w / w) onto the surface of NPS 25-30# in an open pot. In the presence of PVP ethanol solution (5.9% w / w), ibuprofen was dispersed and adhered layer by layer to the surface of NPS25-30# to form ibuprofen drug-loaded pellets.

[0063] The ibuprofen drug-loaded pellets were sealed with PVP ethanol solution in an open pot and dried for 12-36 hours. Then the pellets are placed in a fluidized bed and coated with Opadry to obtain IBU SR pellets.

Embodiment 3

[0064] Example 3: Preparation of capsules containing only PSE SR pellets

[0065] Weigh the PSE SR pellets shown in Table 3. Use an automatic capsule filling machine (model MG2Futura, manufacturer MG2S.r.1.) to fill PSE SR pellets into size 0 extra-long hard gelatin capsules (manufacturer: Suzhou Capsule Co., Ltd.), and you will get only PSE SR pellets capsule.

[0066] Table 3: Capsule formula containing only PSE SR pellets

[0067]

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Abstract

The invention relates to a compound sustained-release capsule for effectively eliminating or relieving cold symptoms, in particular to a compound sustained-release capsule containing ibuprofen sustained-release pellets and pseudo ephedrine sustained-release pellets, wherein the ibuprofen sustained-release pellets and the pseudo ephedrine sustained-release pellets are separated in a capsule shell to prevent the ibuprofen sustained-release pellets and the pseudo ephedrine sustained-release pellets from interfering with each other.

Description

Technical field [0001] The invention relates to the field of medicine. Specifically, the present invention relates to a compound sustained-release capsule that can effectively eliminate or relieve cold symptoms. More specifically, the present invention relates to a compound sustained-release capsule containing ibuprofen sustained-release pellets and pseudoephedrine sustained-release pellets, wherein the ibuprofen sustained-release pellets and pseudoephedrine sustained-release pellets are separated in the capsule shell to prevent Ibuprofen sustained-release pellets and pseudoephedrine sustained-release pellets interfere with each other. Background technique [0002] The use of pellets to prepare sustained-release dosage forms has many advantages, including: (1) The pellets are evenly dispersed in the gastrointestinal tract, which can maximize drug absorption, reduce peak plasma concentration fluctuations and minimize side effects; (2) avoid high local drugs Concentration; (3) Si...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/137A61K9/52A61P29/00A61P11/00
Inventor 赵建胡新辉邵宇S·J·勒施
Owner SINO AMERICAN TIANJIN SMITHKLINE & FRENCH LAB