A kind of Qianxi capsule and preparation method thereof

A technology for capsules and filling capsules, applied in the field of medicine, can solve the problems of complex excipient process, poor friability of plain tablets, affecting the coating process, etc., and achieve the effects of large evaporation surface area, low hygroscopicity, and short heating time.

Active Publication Date: 2015-11-25
江西欧氏药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The disadvantage of the above process is that the granules produced are too loose, which makes the brittleness of the plain tablets poor, resulting in easy cracking and loose tablets during tablet compression, which affects the coating process; a large number of auxiliary materials are required, such as adding disintegrants to solve the problem of disintegration. Solve the problem of sluggishness, add lubricants to solve the problem of sticking and punching during tablet compression, conduct research on coating formulations to solve problems such as mouthfeel and moisture absorption
In short, Qianxi sugar-coated tablets or film-coated tablets have the problem of using multiple excipients and complex processes

Method used

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  • A kind of Qianxi capsule and preparation method thereof
  • A kind of Qianxi capsule and preparation method thereof
  • A kind of Qianxi capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 A kind of preparation method of Qianxi Capsule

[0027] Take Andrographis paniculata 40g and pulverize into fine powder, sieve; 1960 grams of Andrographis paniculata and 2000 grams of Senecio are pulverized into coarse powder, soak with 1.2% sodium hydroxide solution in right amount overnight, add water to percolate, flow rate is 3ml / min per kilogram of medicinal material, collect Percolate about 1000ml, add 1 / 7 amount of saturated saline, then adjust the pH to about 2-3 with hydrochloric acid, stir well, let it stand for 12 hours, discard the supernatant, collect the precipitate, spray dry; add the Andrographis paniculata Fine powder, 30 grams of starch, 7.5 grams of gelatin, mixed evenly, made into granules, dried, filled with 1000 capsules, packed in aluminum-plastic.

Embodiment 2

[0028] Embodiment 2 A kind of preparation method of Qianxi Capsule

[0029] Take 40g of Andrographis paniculata and crush it into fine powder, sieve; the remaining 1960g of Andrographis paniculata and 2000g of Senecio are crushed into coarse powder, soak overnight with an appropriate amount of 1.3% sodium hydroxide solution, add water to percolate at a flow rate of 5ml / min per kilogram of medicinal material, collect Percolate about 1000ml, add 1 / 7 amount of saturated saline, then adjust the pH to about 2-3 with hydrochloric acid, stir well, let it stand for 12 hours, discard the supernatant, collect the precipitate, spray dry; add the Andrographis paniculata Fine powder, 28 grams of starch, 7 grams of gelatin, mixed evenly, made into granules, dried, filled with 1000 granules, and packed in aluminum-plastic.

Embodiment 3

[0031] 3.1 Materials

[0032] Bacteria: Staphylococcus aureus (26003), Escherichia coli (44103), typhoid bacillus (0602-10), Yersinia (52301-5), Shigella dysenteriae (1507-2), Shigella baumannii (51583), Shigella flexneri (51571) (the above strains were all obtained from the China Institute for the Control of Pharmaceutical and Biological Products, Ministry of Health), and Streptococcus B (from the Baozhi strains of the Department of Microbiology, Jiangxi University of Traditional Chinese Medicine).

[0033] Test substance: Qianxi Capsule

[0034] 3.2 Method

[0035] Suspend Qianxi Capsules in 100ml broth, dilute the drug according to the double dilution method, and use the other tube without drug as a control, and dilute the cultures of 9 bacterial strains cultivated for 6 hours to 10 -4 , each tube was inoculated with 0.1ml, incubated for 24 hours, then inoculated in a flat container, incubated at 37°C for 24 hours, determined whether there were colonies, and measured the ...

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Abstract

The invention discloses a qianxi capsule and a preparation method thereof. The capsule is composed of Andrographis paniculata Nees and senecio according to a certain proportion. The preparation method comprises taking a part of the Andrographis paniculata Nees, crushing into fine powder, and sieving; crushing the residual Andrographis paniculata Nees and the senecio into crude powder, percolating, processing the percolating liquid, collecting deposition, and spray drying; adding the above Andrographis paniculata Nees fine powder, starch and proper amount of gelatin, uniformly mixing, preparing into particles, drying and filling to obtain the finish product. The qianxi capsule is safe and effective, has efficacies of clearing away heat and detoxifying, diminishing inflammation and relieving pain and stopping diarrhea shown by pharmacological and clinical studies, and can be clinically used for treating enteritis, colitis, bacterial dysentery, nasosinusitis, etc.

Description

technical field [0001] The invention relates to a Qianxi capsule and a preparation method thereof, belonging to the technical field of medicine. technical background [0002] Enteritis is caused by irritation of the intestinal mucosa and can be divided into acute and chronic. In my country, acute enteritis occurs mostly in summer and autumn, most of which are caused by bacterial infection, and there is no gender difference. Chronic enteritis increases the permeability of the intestinal mucosa, and if it is not cured for a long time, it will lead to intestinal perforation, which is very harmful. [0003] Bacillary dysentery is mostly caused by exogenous damp-heat, epidemic poisonous gas, internal injury to diet, and damage to the spleen, stomach and intestines. Damp-heat poison stagnates in the intestines, qi movement is not smooth, conduction is abnormal, so abdominal pain, tenesmus; damp-heat burns the intestines, the meridian is injured, qi and blood stagnation, turning ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/28A61P1/12A61P29/00
CPCY02A50/30
Inventor 赵凯李新熊丹美黄建丽马朝辉
Owner 江西欧氏药业有限责任公司
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