Chitosan hydrogel for treating haemorrhoids and preparation method thereof

A technology of chitosan water and chitosan, which is applied in the field of chitosan hydrogel, can solve the problems of short duration of action, poor film-forming property, ineffective isolation of intestinal pathogenic bacteria, etc. long time effect

Active Publication Date: 2015-04-29
欧世文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing products for treating hemorrhoids on the market are oral preparations and external ointments. External ointments can directly act on the surface of hemorrhoids, but the ointments have poor film-forming properties in the body and short duration of action, so they cannot effectively isolate intestinal tract. Endopathogens

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Sprinkle 0.103 g (≈0.1%) of carbomer evenly on the water surface of 50 ml of water and let it stand overnight to make it completely swell; dissolve 1 g of chitosan (≈1%) in 50 ml of water to obtain shell The polysaccharide solution was then added to the carbomer solution, and 2 ml of triethanolamine (≈2%) was gradually added under stirring conditions, and fully stirred to make it evenly mixed, and the pH value of the obtained solution was 7.0. After standing at room temperature for 30 min, the chitosan hydrogel was prepared by vacuum degassing.

Embodiment 2

[0024] Sprinkle 1 g (≈1%) of carbomer evenly on the surface of 50 ml of water and let it stand overnight to make it swell completely; dissolve 1 g (≈1%) of chitosan in 50 ml of water to obtain shell The polysaccharide solution was then added to the carbomer solution, and 2 ml of triethanolamine (≈2%) was gradually added under stirring conditions, and fully stirred to make it evenly mixed, and the pH value of the obtained solution was 7.0. After standing at room temperature for 30 min, the chitosan hydrogel was prepared by vacuum degassing.

Embodiment 3

[0026] Sprinkle 2.1g (≈2%) of carbomer evenly on the surface of 50 ml of water and let it stand overnight to make it swell completely; dissolve 1 g of chitosan (≈0.95%) in 50 ml of water to obtain shell The polysaccharide solution was then added to the carbomer solution, and 2 ml of triethanolamine (≈1.9%) was gradually added under stirring conditions, and fully stirred to make it evenly mixed, and the pH value of the obtained solution was 7.0. After standing at room temperature for 30 min, the chitosan hydrogel was prepared by vacuum degassing.

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PUM

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Abstract

The invention discloses chitosan hydrogel for treating haemorrhoids and a preparation method thereof. The chitosan hydrogel for treating haemorrhoids comprises: 0.1 to 10% of chitosan, 0.1 to 2.0% of carbomer, 0.5 to 4.0% of triethylamine and the balance water. Chitosan and carbomer gel are directly mixed and the mixture is prepared into the chitosan hydrogel at a normal temperature without a cross-linking agent. The preparation method is simple. The chitosan hydrogel for treating haemorrhoids has effects of inhibiting a plurality of bacteria, can be cured into a film on the surface of haemorrhoids thereby effectively isolating haemorrhoids from pathogenic bacteria in the intestine, and has an effect of lubrication and thus the chitosan hydrogel can eliminate haemorrhoid clinical symptoms and cure haemorrhoids.

Description

technical field [0001] The invention relates to a chitosan hydrogel for treating hemorrhoids. The invention also relates to a preparation method of the chitosan hydrogel. Background technique [0002] Hemorrhoids are a common multiple disease, which is a soft vein group formed by the expansion and buckling of the venous plexus under the mucous membrane of the end of the rectum and the skin of the anal canal. Most of the existing products for treating hemorrhoids on the market are oral preparations and external ointments. External ointments can directly act on the surface of hemorrhoids, but the ointments have poor film-forming properties in the body and short duration of action, so they cannot effectively isolate intestinal tract. endogenous pathogenic bacteria. The gel is a new type of biomimetic technology preparation. When it is placed in the anorectum, it will immediately disperse in the anorectum, adhere closely to the inner wall of the anorectum, and at the same ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/722A61P9/14
Inventor 欧世文
Owner 欧世文
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