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Production method of gastrodin

A production method and technology for gastrodin, which are applied in the field of medicine, can solve the problems of poor quality stability, low utilization rate of active ingredients and high production cost, and achieve the effects of high paste yield, high utilization rate of active ingredients and lower production cost.

Inactive Publication Date: 2013-03-27
GUIZHOU DAFANG BAILIHUA FOOD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the production of gastrodin pharmaceutical preparations in the prior art, due to different control of process conditions and different excipients added, there are disadvantages such as low utilization rate of active ingredients, poor quality stability, and high production costs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A production method of gastrodin, comprising the following steps:

[0022] (1) Selection of raw materials: select fresh Gastrodia elata tubers without pests and diseases and without mechanical damage, remove surface silt, and rinse with water;

[0023] (2) Pulverization: use a pulverizer to pulverize the Gastrodia elata tubers into fine pieces with a particle size of less than 1cm;

[0024] (3) Extraction: add 80% ethanol twice the weight of Gastrodia elata, heat and extract with an extraction tank, control the temperature at 80°C, and control the time for 1 hour, and extract twice;

[0025] (4) Filtration: filter the extract with a filter and combine the filtrate;

[0026] (5) Concentration: ethanol is recovered from the filtrate under reduced pressure, concentrated to 0.5 g / ml equivalent to the crude drug, and the gastrodin dry extract is obtained;

[0027] (6) Ingredients: add gastrodin dry extract weight 2% sodium carboxymethylcellulose, 1% polysorbate, 30% starch...

Embodiment 2

[0033] A production method of gastrodin, comprising the following steps:

[0034] (1) Crush: Crush the Gastrodia elata tubers into fine pieces with a particle size of less than 1.5cm;

[0035] (2) Extraction: add 80% ethanol which is 3 times the weight of Gastrodia elata fine pieces, heat extraction, control the temperature at 80°C, and control the time for 1 hour, and extract twice;

[0036] (3) Filtration: filter the extract and combine the filtrate;

[0037] (4) Concentration: the filtrate is recovered under reduced pressure to ethanol, concentrated to 0.5 g / ml equivalent to the crude drug, and the gastrodin dry extract is obtained.

[0038]

Embodiment 3

[0040] A production method of gastrodin, comprising the following steps:

[0041] (1) Selection of raw materials: select fresh Gastrodia elata tubers without pests and diseases and without mechanical damage, remove surface silt, and rinse with water;

[0042] (2) Pulverization: use a pulverizer to pulverize the Gastrodia elata tubers into fine pieces with a particle size of less than 0.5cm;

[0043] (3) Extraction: add 80% ethanol which is 4 times the weight of Gastrodia elata, heat and extract with an extraction tank, control the temperature at 80°C, and control the time for 1 hour, and extract twice;

[0044] (4) Filtration: filter the extract with a filter and combine the filtrate;

[0045] (5) Concentration: ethanol is recovered from the filtrate under reduced pressure, concentrated to 0.5 g / ml equivalent to the crude drug, and the gastrodin dry extract is obtained;

[0046] (6) Ingredients: add gastrodin dry extract weight 2% sodium carboxymethylcellulose, 1% polysorbat...

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Abstract

The invention discloses a production method of gastrodin. The production method comprises the following steps: smashing gastrodia elata tubers into fine blocks with the grain diameter smaller than 0.5-1.5cm; adding 80% alcohol with the weight as 2-4 times of gastrodia elata fine blocks, heating for extracting, controlling the temperature at 80 DEG C, controlling the time within 1 hour, and extracting for twice; filtering extractives, and combining filtrate; recovering alcohol from the filtrate in decompression mode, and concentrating to the concentration with the content of crude drug of 0.5g / ml, and obtaining gastrodin dry extract. The production method of gastrodin has the advantages of being high in utilization rate of effective ingredients, good in quality stability of products and low in production cost.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a production method of gastrodin. [0002] Background technique [0003] Gastrodia elata, the dried tuber of Gastrodia elata of the genus Gastrodia elata; Latin name: Rhizom Gastrodiae , Alias: Chijianzhi, Duyaozhi, Limu, Helicao, Shencao, Guiduyou, Mupu, Mingma, Dingfengcao, Bailongpi, Chijian. Its main medicinal ingredient is gastrodin, also known as gastrodin ( gastrodin ), has antiepileptic, anticonvulsant, antirheumatic, sedative, tonic and other therapeutic and tonic functions. When producing gastrodin pharmaceutical preparations in the prior art, due to different control of process conditions and different added excipients, there are disadvantages such as low utilization rate of active ingredients, poor quality stability, and high production cost. [0004] Contents of the invention [0005] The object of the present invention is to overcome the above-mentioned sho...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K31/7034A61K9/48A61P25/08A61P25/20A61P29/00A61P1/14A61K125/00
Inventor 岳心武
Owner GUIZHOU DAFANG BAILIHUA FOOD
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