Preparation method for CT (computed tomography) contrast media based on second-generation polyamide-amine dendrimer/gold nanoparticles

A technology of amine dendrimer and gold nanoparticles, which is applied in the biomedical application field of nanoparticles, can solve the problems of CT contrast performance research without CT contrast agent, and achieve prolonging the residence time in the body, expanding the scale production, and being easy to operate. Effect
CN102989014AInactive Publication Date: 2013-03-27DONGHUA UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DONGHUA UNIV
Publication Date
2013-03-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method for a CT (computed tomography) contrast media based on the second-generation polyamide-amine dendrimer / gold nanoparticles. The preparation method comprises the following steps of: weighing the second-generation polyamide-amine dendrimers with tail ends which are amino groups in aqueous solution, adding chloroauric acid solution in a water-bath condition, and magnetically stirring and reacting for 3 hours; cooling at a room temperature and then performing acetylation treatment; dialyzing the solution after the reaction, performing freeze-drying treatment to obtain a final product; and evaluating the in-vivo and in-vitro CT contrast performances of the product. The product prepared by the preparation method disclosed by the invention is simple and environment-friendly in preparation process, good in stability and cytocompatibility, and capable of showing a good in-vivo CT contrast effect.
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Description

technical field

[0001] The invention belongs to the biomedical application field of nanoparticles, in particular to a preparation method of a CT contrast agent based on second-generation polyamide-amine dendrimers / gold nanoparticles. Background technique

[0002] CT (computed tomography) technology has become one of the most widely used molecular imaging methods because of its excellent spatial and density resolution, and is widely used in clinical practice. Although it has a good imaging effect on bone tissue, the application of CT technology to various organs and other soft tissues is quite limited. In the specific use process, the assistance of contrast agent is often required. Most of the contrast agents currently used clinically are iodine-based small molecule contrast agents. This contrast agent has disadvantages such as short circulation time in the body and potential renal toxicity. Therefore, it is necessary to develop new contrast agents. To date, the developme...

Claims

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