Porous temperature-sensitive hydrogel slow release formulation and preparation method thereof

A temperature-sensitive hydrogel and slow-release agent technology, which is applied in botany equipment and methods, biocides, insecticides, etc., can solve the problems of high preparation conditions, limited application range, and difficult release of drugs, and achieve temperature-sensitive response The effect of fast rate, simple preparation process and short reaction time

Active Publication Date: 2013-04-03
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PNIPAAm gels also have slow swelling, high strength, and difficult drug release, which greatly limits the application of PNIPAAm hydrogels in drug controlled release.
In recent years, fast-response PNIPAAm hydrogel has become the focus of research, and the preparation methods that have been reported include: preparation of PNIPAAm copolymer gel, but the LCST of this gel will change significantly; preparation of PNIPAAm gel under special conditions, such as using phase Separation technology, this method has strict requirements on experimental conditions and is not easy to realize; prepare PNIPAAm microgel by emulsion polymerization, this method has high requirements for preparation conditions and limited application range; preparation of organic / inorganic composite gel Glue; In this method, inorganic materials are added, which are difficult to degrade, so that its application range is greatly limited

Method used

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  • Porous temperature-sensitive hydrogel slow release formulation and preparation method thereof
  • Porous temperature-sensitive hydrogel slow release formulation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] A kind of porous thermosensitive hydrogel sustained-release agent, raw material composition is as follows:

[0060] N-isopropylacrylamide 1.212g,

[0061] N,N'-methylenebisacrylamide 0.012g,

[0062] Polyethylene glycol 10000 1.000g,

[0063] Deltamethrin EC 0.2mL,

[0064]Tetramethylethylenediamine 0.012g,

[0065] Ammonium persulfate 0.012g,

[0066] Water 10mL.

[0067] The preparation method is as follows:

[0068] Dissolve N-isopropylacrylamide and N,N'-methylenebisacrylamide in deionized water to make a uniform solution, then add polyethylene glycol 10000, stir to dissolve, and then add deltamethrin EC ( Enemy kill), stir and disperse evenly; pass N 2 30min to remove O in the system 2 , and then add ammonium persulfate, stir to dissolve, continue to pass nitrogen for 5 minutes, add tetramethylethylenediamine, seal, and react at 25°C for 10h to obtain the product.

[0069] attached figure 1 It is a scanning electron micrograph of the hydrogel prepared in ...

Embodiment 2

[0071] A kind of porous thermosensitive hydrogel sustained-release agent, raw material composition is as follows:

[0072] N-isopropylacrylamide 0.405g,

[0073] N,N'-methylenebisacrylamide 0.012g,

[0074] Polyethylene glycol 10000 1.000g,

[0075] Deltamethrin EC 0.2mL,

[0076] Tetramethylethylenediamine 0.012g,

[0077] Ammonium persulfate 0.012g,

[0078] Water 10mL.

[0079] The preparation method is as follows:

[0080] Dissolve N-isopropylacrylamide and N,N'-methylenebisacrylamide in deionized water to make a uniform solution, then add polyethylene glycol 10000, stir to dissolve, and then add deltamethrin EC ( Enemy kill), stir and disperse evenly; pass N 2 20min to remove O in the system 2 , and then add ammonium persulfate, stir to dissolve, continue to pass nitrogen for 5 minutes, add tetramethylethylenediamine, seal, and react at 25°C for 12h to obtain the product.

Embodiment 3

[0082] A kind of porous thermosensitive hydrogel sustained-release agent, raw material composition is as follows:

[0083] N-isopropylacrylamide 0.806g,

[0084] N,N'-methylenebisacrylamide 0.013g,

[0085] Polyethylene glycol 10000 1.000g,

[0086] Deltamethrin EC 0.2mL,

[0087] Tetramethylethylenediamine 0.012g,

[0088] Ammonium persulfate 0.013g,

[0089] Water 10mLl.

[0090] The preparation method is as follows:

[0091] Dissolve N-isopropylacrylamide and N,N'-methylenebisacrylamide in deionized water to make a uniform solution, then add polyethylene glycol 10000, stir to dissolve, and then add deltamethrin EC, Stir to disperse evenly; pass N 2 30min to remove O in the system 2 , and then add ammonium persulfate, stir to dissolve, continue to pass nitrogen for 5 minutes, add tetramethylethylenediamine, seal, and react at 25°C for 8h to obtain.

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Abstract

The invention relates to a porous temperature-sensitive hydrogel slow release formulation and a preparation method thereof. The preparation method comprises the steps of taking poly(N-isopropylacrylamide) porous temperature-sensitive hydrogel as a carrier, loading drugs in the hydrogel, thereby realizing controlled release of the drug by utilizing the temperature sensitivity characteristic of the poly(N-isopropylacrylamide). When the temperature is lower than the LCST (Lower Critical Solution Temperature) of the hydrogel, the drug release is slow, and when the temperature is higher than the LCST, the release speed is accelerated. The preparation method can be used for preparing temperature-sensitive sustained-release pesticide and insecticide, the drug use frequency can be reduced by utilizing the temperature-sensitive sustained-release property, and the effects of improving the pesticide effect and reducing the toxicity can be achieved. The porous temperature-sensitive hydrogel sustained-release inhibitor is fast to react, and simple in technique, has good temperature-sensitive characteristic and sustained-release property, is convenient to use, safe and efficient, thereby having wide application prospects.

Description

technical field [0001] The invention relates to the technical field of preparation of functional polymer materials, in particular to a temperature-sensitive porous hydrogel slow-release agent and a preparation method thereof. Background technique [0002] Smart hydrogels are an important branch of functional polymer materials. Hydrogel is a gel in which water is used as a dispersion medium, and a part of hydrophobic groups are introduced into water-soluble polymers with a cross-linked structure to form a cross-linked polymer that can swell with water. It has a three-dimensional network structure with mild chemical cross-linking and intertwined molecular chains (physical cross-linking), and small hydrophilic molecules can diffuse in the hydrogel. According to the response of hydrogels to external stimuli, hydrogels can be divided into two categories: one is traditional hydrogels, which are not particularly sensitive to environmental changes; the other is environmentally sens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/04A01N53/08A01P7/04C08F220/54C08F222/38C08F222/14C08F2/44C08J3/075
Inventor 谭业邦刘发文
Owner SHANDONG UNIV
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